Abstract
Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 × 10−8) with left-handedness and 7 associated with ambidexterity. Tissue-enrichment analysis implicated the CNS in the aetiology of handedness. Pathways including regulation of microtubules and brain morphology were also highlighted. We found suggestive positive genetic correlations between left-handedness and neuropsychiatric traits, including schizophrenia and bipolar disorder. Furthermore, the genetic correlation between left-handedness and ambidexterity is low (rG = 0.26), which implies that these traits are largely influenced by different genetic mechanisms. Our findings suggest that handedness is highly polygenic and that the genetic variants that predispose to left-handedness may underlie part of the association with some psychiatric disorders.
Original language | English |
---|---|
Pages (from-to) | 59-70 |
Number of pages | 12 |
Journal | Nature Human Behaviour |
Volume | 5 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2021 |
Access to Document
Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver
}
Genome-wide association study identifies 48 common genetic variants associated with handedness. / Cuellar-Partida, Gabriel; Tung, Joyce Y.; Eriksson, Nicholas; Albrecht, Eva; Aliev, Fazil; Andreassen, Ole A.; Barroso, Inês; Beckmann, Jacques S.; Boks, Marco P.; Boomsma, Dorret I.; Boyd, Heather A.; Breteler, Monique M.B.; Campbell, Harry; Chasman, Daniel I.; Cherkas, Lynn F.; Davies, Gail; de Geus, Eco J.C.; Deary, Ian J.; Deloukas, Panos; Dick, Danielle M.; Duffy, David L.; Eriksson, Johan G.; Esko, Tõnu; Feenstra, Bjarke; Geller, Frank; Gieger, Christian; Giegling, Ina; Gordon, Scott D.; Han, Jiali; Hansen, Thomas F.; Hartmann, Annette M.; Hayward, Caroline; Heikkilä, Kauko; Hicks, Andrew A.; Hirschhorn, Joel N.; Hottenga, Jouke Jan; Huffman, Jennifer E.; Hwang, Liang Dar; Ikram, M. Arfan; Kaprio, Jaakko; Kemp, John P.; Khaw, Kay Tee; Klopp, Norman; Konte, Bettina; Kutalik, Zoltan; Lahti, Jari; Li, Xin; Loos, Ruth J.F.; Luciano, Michelle; Magnusson, Sigurdur H.; Mangino, Massimo; Marques-Vidal, Pedro; Martin, Nicholas G.; McArdle, Wendy L.; McCarthy, Mark I.; Medina-Gomez, Carolina; Melbye, Mads; Melville, Scott A.; Metspalu, Andres; Milani, Lili; Mooser, Vincent; Nelis, Mari; Nyholt, Dale R.; O’Connell, Kevin S.; Ophoff, Roel A.; Palmer, Cameron; Palotie, Aarno; Palviainen, Teemu; Pare, Guillaume; Paternoster, Lavinia; Peltonen, Leena; Penninx, Brenda W.J.H.; Polasek, Ozren; Pramstaller, Peter P.; Prokopenko, Inga; Raikkonen, Katri; Ripatti, Samuli; Rivadeneira, Fernando; Rudan, Igor; Rujescu, Dan; Smit, Johannes H.; Smith, George Davey; Smoller, Jordan W.; Soranzo, Nicole; Spector, Tim D.; Pourcain, Beate St; Starr, John M.; Stefánsson, Hreinn; Steinberg, Stacy; Teder-Laving, Maris; Thorleifsson, Gudmar; Stefánsson, Kári; Timpson, Nicholas J.; Uitterlinden, André G.; van Duijn, Cornelia M.; van Rooij, Frank J.A.; Vink, Jaqueline M.; Vollenweider, Peter; Vuoksimaa, Eero; Waeber, Gérard; Wareham, Nicholas J.; Warrington, Nicole; Waterworth, Dawn; Werge, Thomas; Wichmann, H. Erich; Widen, Elisabeth; Willemsen, Gonneke; Wright, Alan F.; Wright, Margaret J.; Xu, Mousheng; Zhao, Jing Hua; Kraft, Peter; Hinds, David A.; Lindgren, Cecilia M.; Mägi, Reedik; Neale, Benjamin M.; Evans, David M.; Medland, Sarah E.
In: Nature Human Behaviour, Vol. 5, No. 1, 01.2021, p. 59-70.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Genome-wide association study identifies 48 common genetic variants associated with handedness
AU - Cuellar-Partida, Gabriel
AU - Tung, Joyce Y.
AU - Eriksson, Nicholas
AU - Albrecht, Eva
AU - Aliev, Fazil
AU - Andreassen, Ole A.
AU - Barroso, Inês
AU - Beckmann, Jacques S.
AU - Boks, Marco P.
AU - Boomsma, Dorret I.
AU - Boyd, Heather A.
AU - Breteler, Monique M.B.
AU - Campbell, Harry
AU - Chasman, Daniel I.
AU - Cherkas, Lynn F.
AU - Davies, Gail
AU - de Geus, Eco J.C.
AU - Deary, Ian J.
AU - Deloukas, Panos
AU - Dick, Danielle M.
AU - Duffy, David L.
AU - Eriksson, Johan G.
AU - Esko, Tõnu
AU - Feenstra, Bjarke
AU - Geller, Frank
AU - Gieger, Christian
AU - Giegling, Ina
AU - Gordon, Scott D.
AU - Han, Jiali
AU - Hansen, Thomas F.
AU - Hartmann, Annette M.
AU - Hayward, Caroline
AU - Heikkilä, Kauko
AU - Hicks, Andrew A.
AU - Hirschhorn, Joel N.
AU - Hottenga, Jouke Jan
AU - Huffman, Jennifer E.
AU - Hwang, Liang Dar
AU - Ikram, M. Arfan
AU - Kaprio, Jaakko
AU - Kemp, John P.
AU - Khaw, Kay Tee
AU - Klopp, Norman
AU - Konte, Bettina
AU - Kutalik, Zoltan
AU - Lahti, Jari
AU - Li, Xin
AU - Loos, Ruth J.F.
AU - Luciano, Michelle
AU - Magnusson, Sigurdur H.
AU - Mangino, Massimo
AU - Marques-Vidal, Pedro
AU - Martin, Nicholas G.
AU - McArdle, Wendy L.
AU - McCarthy, Mark I.
AU - Medina-Gomez, Carolina
AU - Melbye, Mads
AU - Melville, Scott A.
AU - Metspalu, Andres
AU - Milani, Lili
AU - Mooser, Vincent
AU - Nelis, Mari
AU - Nyholt, Dale R.
AU - O’Connell, Kevin S.
AU - Ophoff, Roel A.
AU - Palmer, Cameron
AU - Palotie, Aarno
AU - Palviainen, Teemu
AU - Pare, Guillaume
AU - Paternoster, Lavinia
AU - Peltonen, Leena
AU - Penninx, Brenda W.J.H.
AU - Polasek, Ozren
AU - Pramstaller, Peter P.
AU - Prokopenko, Inga
AU - Raikkonen, Katri
AU - Ripatti, Samuli
AU - Rivadeneira, Fernando
AU - Rudan, Igor
AU - Rujescu, Dan
AU - Smit, Johannes H.
AU - Smith, George Davey
AU - Smoller, Jordan W.
AU - Soranzo, Nicole
AU - Spector, Tim D.
AU - Pourcain, Beate St
AU - Starr, John M.
AU - Stefánsson, Hreinn
AU - Steinberg, Stacy
AU - Teder-Laving, Maris
AU - Thorleifsson, Gudmar
AU - Stefánsson, Kári
AU - Timpson, Nicholas J.
AU - Uitterlinden, André G.
AU - van Duijn, Cornelia M.
AU - van Rooij, Frank J.A.
AU - Vink, Jaqueline M.
AU - Vollenweider, Peter
AU - Vuoksimaa, Eero
AU - Waeber, Gérard
AU - Wareham, Nicholas J.
AU - Warrington, Nicole
AU - Waterworth, Dawn
AU - Werge, Thomas
AU - Wichmann, H. Erich
AU - Widen, Elisabeth
AU - Willemsen, Gonneke
AU - Wright, Alan F.
AU - Wright, Margaret J.
AU - Xu, Mousheng
AU - Zhao, Jing Hua
AU - Kraft, Peter
AU - Hinds, David A.
AU - Lindgren, Cecilia M.
AU - Mägi, Reedik
AU - Neale, Benjamin M.
AU - Evans, David M.
AU - Medland, Sarah E.
PY - 2021/1
Y1 - 2021/1
N2 - Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 × 10−8) with left-handedness and 7 associated with ambidexterity. Tissue-enrichment analysis implicated the CNS in the aetiology of handedness. Pathways including regulation of microtubules and brain morphology were also highlighted. We found suggestive positive genetic correlations between left-handedness and neuropsychiatric traits, including schizophrenia and bipolar disorder. Furthermore, the genetic correlation between left-handedness and ambidexterity is low (rG = 0.26), which implies that these traits are largely influenced by different genetic mechanisms. Our findings suggest that handedness is highly polygenic and that the genetic variants that predispose to left-handedness may underlie part of the association with some psychiatric disorders.
AB - Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 × 10−8) with left-handedness and 7 associated with ambidexterity. Tissue-enrichment analysis implicated the CNS in the aetiology of handedness. Pathways including regulation of microtubules and brain morphology were also highlighted. We found suggestive positive genetic correlations between left-handedness and neuropsychiatric traits, including schizophrenia and bipolar disorder. Furthermore, the genetic correlation between left-handedness and ambidexterity is low (rG = 0.26), which implies that these traits are largely influenced by different genetic mechanisms. Our findings suggest that handedness is highly polygenic and that the genetic variants that predispose to left-handedness may underlie part of the association with some psychiatric disorders.
UR - http://www.scopus.com/inward/record.url?scp=85091609696&partnerID=8YFLogxK
U2 - 10.1038/s41562-020-00956-y
DO - 10.1038/s41562-020-00956-y
M3 - Article
C2 - 32989287
AN - SCOPUS:85091609696
VL - 5
SP - 59
EP - 70
JO - Nature Human Behaviour
JF - Nature Human Behaviour
SN - 2397-3374
IS - 1
ER -