Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium

C. C. Minică, D. F. Maciejewski, Cannabis Consortium

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Cannabis is the most widely produced and consumed illicit psychoactive substance worldwide. Occasional cannabis use can progress to frequent use, abuse and dependence with all known adverse physical, psychological and social consequences. Individual differences in cannabis initiation are heritable (40-48%). The International Cannabis Consortium was established with the aim to identify genetic risk variants of cannabis use. We conducted a meta-analysis of genome-wide association data of 13 cohorts (N=32 330) and four replication samples (N=5627). In addition, we performed a gene-based test of association, estimated single-nucleotide polymorphism (SNP)-based heritability and explored the genetic correlation between lifetime cannabis use and cigarette use using LD score regression. No individual SNPs reached genome-wide significance. Nonetheless, gene-based tests identified four genes significantly associated with lifetime cannabis use: NCAM1, CADM2, SCOC and KCNT2. Previous studies reported associations of NCAM1 with cigarette smoking and other substance use, and those of CADM2 with body mass index, processing speed and autism disorders, which are phenotypes previously reported to be associated with cannabis use. Furthermore, we showed that, combined across the genome, all common SNPs explained 13-20% (P
Original languageEnglish
Pages (from-to)e769
JournalTranslational psychiatry
DOIs
Publication statusPublished - 29 Mar 2016

Cite this

@article{33770a4bba1047bba80ad4dcc2b6b6bc,
title = "Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium",
abstract = "Cannabis is the most widely produced and consumed illicit psychoactive substance worldwide. Occasional cannabis use can progress to frequent use, abuse and dependence with all known adverse physical, psychological and social consequences. Individual differences in cannabis initiation are heritable (40-48{\%}). The International Cannabis Consortium was established with the aim to identify genetic risk variants of cannabis use. We conducted a meta-analysis of genome-wide association data of 13 cohorts (N=32 330) and four replication samples (N=5627). In addition, we performed a gene-based test of association, estimated single-nucleotide polymorphism (SNP)-based heritability and explored the genetic correlation between lifetime cannabis use and cigarette use using LD score regression. No individual SNPs reached genome-wide significance. Nonetheless, gene-based tests identified four genes significantly associated with lifetime cannabis use: NCAM1, CADM2, SCOC and KCNT2. Previous studies reported associations of NCAM1 with cigarette smoking and other substance use, and those of CADM2 with body mass index, processing speed and autism disorders, which are phenotypes previously reported to be associated with cannabis use. Furthermore, we showed that, combined across the genome, all common SNPs explained 13-20{\%} (P",
author = "S. Stringer and Minică, {C. C.} and Verweij, {K. J.H.} and H. Mbarek and M. Bernard and J. Derringer and {van Eijk}, {K. R.} and Isen, {J. D.} and A. Loukola and Maciejewski, {D. F.} and E. Mihailov and {van der Most}, {P. J.} and C. S{\'a}nchez-Mora and L. Roos and R. Sherva and R. Walters and Ware, {J. J.} and A. Abdellaoui and Bigdeli, {T. B.} and Branje, {S. J.T.} and Brown, {S. A.} and M. Bruinenberg and M. Casas and T. Esko and I. Garcia-Martinez and Gordon, {S. D.} and Harris, {J. M.} and Hartman, {C. A.} and Henders, {A. K.} and Heath, {A. C.} and Hickie, {I. B.} and M. Hickman and Hopfer, {C. J.} and Hottenga, {J. J.} and Huizink, {A. C.} and Irons, {D. E.} and Kahn, {R. S.} and T. Korhonen and Kranzler, {H. R.} and K. Krauter and {van Lier}, {P. A.C.} and Lubke, {G. H.} and Madden, {P. A.F.} and R. M{\"a}gi and McGue, {M. K.} and Medland, {S. E.} and Meeus, {W. H.J.} and Miller, {M. B.} and Boks, {M. P.} and Vink, {J. M.} and {Cannabis Consortium}",
year = "2016",
month = "3",
day = "29",
doi = "10.1038/tp.2016.36",
language = "English",
pages = "e769",
journal = "Translational psychiatry",
issn = "2158-3188",

}

Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium. / Minică, C. C.; Maciejewski, D. F.; Cannabis Consortium.

In: Translational psychiatry, 29.03.2016, p. e769.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium

AU - Stringer, S.

AU - Minică, C. C.

AU - Verweij, K. J.H.

AU - Mbarek, H.

AU - Bernard, M.

AU - Derringer, J.

AU - van Eijk, K. R.

AU - Isen, J. D.

AU - Loukola, A.

AU - Maciejewski, D. F.

AU - Mihailov, E.

AU - van der Most, P. J.

AU - Sánchez-Mora, C.

AU - Roos, L.

AU - Sherva, R.

AU - Walters, R.

AU - Ware, J. J.

AU - Abdellaoui, A.

AU - Bigdeli, T. B.

AU - Branje, S. J.T.

AU - Brown, S. A.

AU - Bruinenberg, M.

AU - Casas, M.

AU - Esko, T.

AU - Garcia-Martinez, I.

AU - Gordon, S. D.

AU - Harris, J. M.

AU - Hartman, C. A.

AU - Henders, A. K.

AU - Heath, A. C.

AU - Hickie, I. B.

AU - Hickman, M.

AU - Hopfer, C. J.

AU - Hottenga, J. J.

AU - Huizink, A. C.

AU - Irons, D. E.

AU - Kahn, R. S.

AU - Korhonen, T.

AU - Kranzler, H. R.

AU - Krauter, K.

AU - van Lier, P. A.C.

AU - Lubke, G. H.

AU - Madden, P. A.F.

AU - Mägi, R.

AU - McGue, M. K.

AU - Medland, S. E.

AU - Meeus, W. H.J.

AU - Miller, M. B.

AU - Boks, M. P.

AU - Vink, J. M.

AU - Cannabis Consortium

PY - 2016/3/29

Y1 - 2016/3/29

N2 - Cannabis is the most widely produced and consumed illicit psychoactive substance worldwide. Occasional cannabis use can progress to frequent use, abuse and dependence with all known adverse physical, psychological and social consequences. Individual differences in cannabis initiation are heritable (40-48%). The International Cannabis Consortium was established with the aim to identify genetic risk variants of cannabis use. We conducted a meta-analysis of genome-wide association data of 13 cohorts (N=32 330) and four replication samples (N=5627). In addition, we performed a gene-based test of association, estimated single-nucleotide polymorphism (SNP)-based heritability and explored the genetic correlation between lifetime cannabis use and cigarette use using LD score regression. No individual SNPs reached genome-wide significance. Nonetheless, gene-based tests identified four genes significantly associated with lifetime cannabis use: NCAM1, CADM2, SCOC and KCNT2. Previous studies reported associations of NCAM1 with cigarette smoking and other substance use, and those of CADM2 with body mass index, processing speed and autism disorders, which are phenotypes previously reported to be associated with cannabis use. Furthermore, we showed that, combined across the genome, all common SNPs explained 13-20% (P

AB - Cannabis is the most widely produced and consumed illicit psychoactive substance worldwide. Occasional cannabis use can progress to frequent use, abuse and dependence with all known adverse physical, psychological and social consequences. Individual differences in cannabis initiation are heritable (40-48%). The International Cannabis Consortium was established with the aim to identify genetic risk variants of cannabis use. We conducted a meta-analysis of genome-wide association data of 13 cohorts (N=32 330) and four replication samples (N=5627). In addition, we performed a gene-based test of association, estimated single-nucleotide polymorphism (SNP)-based heritability and explored the genetic correlation between lifetime cannabis use and cigarette use using LD score regression. No individual SNPs reached genome-wide significance. Nonetheless, gene-based tests identified four genes significantly associated with lifetime cannabis use: NCAM1, CADM2, SCOC and KCNT2. Previous studies reported associations of NCAM1 with cigarette smoking and other substance use, and those of CADM2 with body mass index, processing speed and autism disorders, which are phenotypes previously reported to be associated with cannabis use. Furthermore, we showed that, combined across the genome, all common SNPs explained 13-20% (P

U2 - 10.1038/tp.2016.36

DO - 10.1038/tp.2016.36

M3 - Article

SP - e769

JO - Translational psychiatry

JF - Translational psychiatry

SN - 2158-3188

ER -