Genome-Wide Significance for PCLO as a Gene for Major Depressive Disorder

Hamdi Mbarek, Yuri Milaneschi, Jouke Jan Hottenga, Lannie Ligthart, Eco J.C. De Geus, Erik A. Ehli, Gonneke Willemsen, Gareth E. Davies, Jan H. Smit, Dorret I. Boomsma, Brenda W.J.H. Penninx

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

In 2009, the first genome-wide association study (GWAS) for major depressive disorder (MDD) highlighted an association with PCLO locus on chromosome 7, although not reaching genome-wide significance level. In the present study, we revisited the original GWAS after increasing the overall sample size and the number of interrogated SNPs. In an analysis comparing 1,942 cases with lifetime diagnosis of MDD and 4,565 controls, PCLO showed a genome-wide significant association with MDD at SNP (rs2715157, p = 2.91 × 10-8) and gene-based (p = 1.48 × 10-7) level. Our results confirm the potential role of the PCLO gene in MDD, which is worth further replication and functional studies.

Original languageEnglish
Pages (from-to)267-270
Number of pages4
JournalTwin Research and Human Genetics
Volume20
Issue number4
DOIs
Publication statusPublished - 1 Aug 2017

Cite this

Mbarek, Hamdi ; Milaneschi, Yuri ; Hottenga, Jouke Jan ; Ligthart, Lannie ; De Geus, Eco J.C. ; Ehli, Erik A. ; Willemsen, Gonneke ; Davies, Gareth E. ; Smit, Jan H. ; Boomsma, Dorret I. ; Penninx, Brenda W.J.H. / Genome-Wide Significance for PCLO as a Gene for Major Depressive Disorder. In: Twin Research and Human Genetics. 2017 ; Vol. 20, No. 4. pp. 267-270.
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abstract = "In 2009, the first genome-wide association study (GWAS) for major depressive disorder (MDD) highlighted an association with PCLO locus on chromosome 7, although not reaching genome-wide significance level. In the present study, we revisited the original GWAS after increasing the overall sample size and the number of interrogated SNPs. In an analysis comparing 1,942 cases with lifetime diagnosis of MDD and 4,565 controls, PCLO showed a genome-wide significant association with MDD at SNP (rs2715157, p = 2.91 × 10-8) and gene-based (p = 1.48 × 10-7) level. Our results confirm the potential role of the PCLO gene in MDD, which is worth further replication and functional studies.",
keywords = "genetics, genome-wide association study, major depressive disorder, PCLO",
author = "Hamdi Mbarek and Yuri Milaneschi and Hottenga, {Jouke Jan} and Lannie Ligthart and {De Geus}, {Eco J.C.} and Ehli, {Erik A.} and Gonneke Willemsen and Davies, {Gareth E.} and Smit, {Jan H.} and Boomsma, {Dorret I.} and Penninx, {Brenda W.J.H.}",
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Mbarek, H, Milaneschi, Y, Hottenga, JJ, Ligthart, L, De Geus, EJC, Ehli, EA, Willemsen, G, Davies, GE, Smit, JH, Boomsma, DI & Penninx, BWJH 2017, 'Genome-Wide Significance for PCLO as a Gene for Major Depressive Disorder' Twin Research and Human Genetics, vol. 20, no. 4, pp. 267-270. https://doi.org/10.1017/thg.2017.30

Genome-Wide Significance for PCLO as a Gene for Major Depressive Disorder. / Mbarek, Hamdi; Milaneschi, Yuri; Hottenga, Jouke Jan; Ligthart, Lannie; De Geus, Eco J.C.; Ehli, Erik A.; Willemsen, Gonneke; Davies, Gareth E.; Smit, Jan H.; Boomsma, Dorret I.; Penninx, Brenda W.J.H.

In: Twin Research and Human Genetics, Vol. 20, No. 4, 01.08.2017, p. 267-270.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Genome-Wide Significance for PCLO as a Gene for Major Depressive Disorder

AU - Mbarek, Hamdi

AU - Milaneschi, Yuri

AU - Hottenga, Jouke Jan

AU - Ligthart, Lannie

AU - De Geus, Eco J.C.

AU - Ehli, Erik A.

AU - Willemsen, Gonneke

AU - Davies, Gareth E.

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AU - Penninx, Brenda W.J.H.

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