Genomics of Alzheimer’s disease

Margot P. van de Weijer, Iris E. Jansen, Anouk H.A. Verboven, Ole A. Andreassen, Danielle Posthuma

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Abstract

Since the advent of genome-wide association studies, there have been rapid developments in genomics research into Alzheimer’s disease (AD). Research in the past decade has brought forward many novel AD-susceptibility loci, and has identified many new biological pathways influencing AD pathology. These new insights are crucial for our understanding of the biology of AD, and offer new opportunities for medical targets and interventions for the prevention and/or treatment of AD. Here, we review the most important developments in genomics research for AD since the advent of genome-wide association studies. Moreover, we provide a brief overview of other -omics approaches for AD, and elaborate on the advantages of multiple -omics approaches for investigating complex disorders such as AD.

Original languageEnglish
Title of host publicationPersonalized Psychiatry
PublisherElsevier
Pages275-283
Number of pages9
ISBN (Electronic)9780128131763
ISBN (Print)9780128131770
DOIs
Publication statusPublished - 1 Jan 2019

Cite this

van de Weijer, M. P., Jansen, I. E., Verboven, A. H. A., Andreassen, O. A., & Posthuma, D. (2019). Genomics of Alzheimer’s disease. In Personalized Psychiatry (pp. 275-283). Elsevier. https://doi.org/10.1016/B978-0-12-813176-3.00022-5