Abstract

Background: While glucocorticosteroids (GCS) are widely used in patients with kidney disease, little is known about their effect on serum creatinine, the most commonly used endogenous marker of kidney function. Methods: We assessed the effect of GCS on the relationship between estimated GFR using the Schwartz equation (eGFR) and measured GFR using a single-injection inulin clearance (Cin) in children both in a paired analysis and a cross-sectional study. Primary outcome variable was the difference between eGFR and Cin (ΔGFR) in a paired analysis involving 22 patients during and off GCS treatment (mean GFR 103.8 ml/min/1.73 m2, mean prednisone dose 34.8 mg/m2/day). In a cross-sectional analysis in 42 patients receiving GCS (mean dose of 25.7 mg/m2/day), a dose-dependent effect was explored using univariate and multivariate linear regression of various variables including GCS dosage with serum creatinine as dependent variable. Results: The paired analysis showed no significant difference in ΔGFR with or without GCS [− 23 (SD 53) vs. − 9 (SD 41) ml/min/1.73 m2, p = 0.203]. Stepwise multivariate linear regression analysis showed a significant correlation between age and Cin, while GCS dose was not related to serum creatinine. Conclusion: GCS use had no significant effect on serum creatinine as a marker for kidney function in a mixed population of renal outpatient clinic children.
Original languageEnglish
Pages (from-to)1163-1166
JournalClinical and Experimental Nephrology
Volume22
Issue number5
DOIs
Publication statusPublished - 2018

Cite this

@article{8100dd3261794781bf8cc4702205498b,
title = "GFR-estimation by serum creatinine during glucocorticosteroid therapy",
abstract = "Background: While glucocorticosteroids (GCS) are widely used in patients with kidney disease, little is known about their effect on serum creatinine, the most commonly used endogenous marker of kidney function. Methods: We assessed the effect of GCS on the relationship between estimated GFR using the Schwartz equation (eGFR) and measured GFR using a single-injection inulin clearance (Cin) in children both in a paired analysis and a cross-sectional study. Primary outcome variable was the difference between eGFR and Cin (ΔGFR) in a paired analysis involving 22 patients during and off GCS treatment (mean GFR 103.8 ml/min/1.73 m2, mean prednisone dose 34.8 mg/m2/day). In a cross-sectional analysis in 42 patients receiving GCS (mean dose of 25.7 mg/m2/day), a dose-dependent effect was explored using univariate and multivariate linear regression of various variables including GCS dosage with serum creatinine as dependent variable. Results: The paired analysis showed no significant difference in ΔGFR with or without GCS [− 23 (SD 53) vs. − 9 (SD 41) ml/min/1.73 m2, p = 0.203]. Stepwise multivariate linear regression analysis showed a significant correlation between age and Cin, while GCS dose was not related to serum creatinine. Conclusion: GCS use had no significant effect on serum creatinine as a marker for kidney function in a mixed population of renal outpatient clinic children.",
author = "{den Bakker}, Emil and Berend Koene and {van Wijk}, {Joanna A. E.} and Isabelle Hubeek and Reinoud Gemke and Arend B{\"o}kenkamp",
year = "2018",
doi = "10.1007/s10157-018-1570-6",
language = "English",
volume = "22",
pages = "1163--1166",
journal = "Clinical and Experimental Nephrology",
issn = "1342-1751",
publisher = "Springer Japan",
number = "5",

}

GFR-estimation by serum creatinine during glucocorticosteroid therapy. / den Bakker, Emil; Koene, Berend; van Wijk, Joanna A. E.; Hubeek, Isabelle; Gemke, Reinoud; Bökenkamp, Arend.

In: Clinical and Experimental Nephrology, Vol. 22, No. 5, 2018, p. 1163-1166.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - GFR-estimation by serum creatinine during glucocorticosteroid therapy

AU - den Bakker, Emil

AU - Koene, Berend

AU - van Wijk, Joanna A. E.

AU - Hubeek, Isabelle

AU - Gemke, Reinoud

AU - Bökenkamp, Arend

PY - 2018

Y1 - 2018

N2 - Background: While glucocorticosteroids (GCS) are widely used in patients with kidney disease, little is known about their effect on serum creatinine, the most commonly used endogenous marker of kidney function. Methods: We assessed the effect of GCS on the relationship between estimated GFR using the Schwartz equation (eGFR) and measured GFR using a single-injection inulin clearance (Cin) in children both in a paired analysis and a cross-sectional study. Primary outcome variable was the difference between eGFR and Cin (ΔGFR) in a paired analysis involving 22 patients during and off GCS treatment (mean GFR 103.8 ml/min/1.73 m2, mean prednisone dose 34.8 mg/m2/day). In a cross-sectional analysis in 42 patients receiving GCS (mean dose of 25.7 mg/m2/day), a dose-dependent effect was explored using univariate and multivariate linear regression of various variables including GCS dosage with serum creatinine as dependent variable. Results: The paired analysis showed no significant difference in ΔGFR with or without GCS [− 23 (SD 53) vs. − 9 (SD 41) ml/min/1.73 m2, p = 0.203]. Stepwise multivariate linear regression analysis showed a significant correlation between age and Cin, while GCS dose was not related to serum creatinine. Conclusion: GCS use had no significant effect on serum creatinine as a marker for kidney function in a mixed population of renal outpatient clinic children.

AB - Background: While glucocorticosteroids (GCS) are widely used in patients with kidney disease, little is known about their effect on serum creatinine, the most commonly used endogenous marker of kidney function. Methods: We assessed the effect of GCS on the relationship between estimated GFR using the Schwartz equation (eGFR) and measured GFR using a single-injection inulin clearance (Cin) in children both in a paired analysis and a cross-sectional study. Primary outcome variable was the difference between eGFR and Cin (ΔGFR) in a paired analysis involving 22 patients during and off GCS treatment (mean GFR 103.8 ml/min/1.73 m2, mean prednisone dose 34.8 mg/m2/day). In a cross-sectional analysis in 42 patients receiving GCS (mean dose of 25.7 mg/m2/day), a dose-dependent effect was explored using univariate and multivariate linear regression of various variables including GCS dosage with serum creatinine as dependent variable. Results: The paired analysis showed no significant difference in ΔGFR with or without GCS [− 23 (SD 53) vs. − 9 (SD 41) ml/min/1.73 m2, p = 0.203]. Stepwise multivariate linear regression analysis showed a significant correlation between age and Cin, while GCS dose was not related to serum creatinine. Conclusion: GCS use had no significant effect on serum creatinine as a marker for kidney function in a mixed population of renal outpatient clinic children.

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DO - 10.1007/s10157-018-1570-6

M3 - Article

VL - 22

SP - 1163

EP - 1166

JO - Clinical and Experimental Nephrology

JF - Clinical and Experimental Nephrology

SN - 1342-1751

IS - 5

ER -