Glucocorticoid-mediated modulation of morphological changes associated with aging in microglia

Lynn van Olst, Pascal Bielefeld, Carlos P Fitzsimons, Helga E de Vries, Marijn Schouten

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Microglia dynamically adapt their morphology and function during increasing age. However, the mechanisms behind these changes are to date poorly understood. Glucocorticoids (GCs) are long known and utilized for their immunomodulatory actions and endogenous GC levels are described to alter with advancing age. We here tested the hypothesis that age-associated elevations in GC levels implicate microglia function and morphology. Our data indicate a decrease in microglial complexity and a concomitant increase in GC levels during aging. Interestingly, enhancing GC levels in young mice enhanced microglial ramifications, while the knockdown of the glucocorticoid receptor expression in old mice aggravated age-associated microglial amoebification. These data suggest that GCs increase ramification of hippocampal microglia and may modulate age-associated changes in microglial morphology.

Original languageEnglish
Article numbere12790
JournalAging Cell
Volume17
Issue number4
Early online date7 Jun 2018
DOIs
Publication statusPublished - 1 Aug 2018

Cite this

van Olst, Lynn ; Bielefeld, Pascal ; Fitzsimons, Carlos P ; de Vries, Helga E ; Schouten, Marijn. / Glucocorticoid-mediated modulation of morphological changes associated with aging in microglia. In: Aging Cell. 2018 ; Vol. 17, No. 4.
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Glucocorticoid-mediated modulation of morphological changes associated with aging in microglia. / van Olst, Lynn; Bielefeld, Pascal; Fitzsimons, Carlos P; de Vries, Helga E; Schouten, Marijn.

In: Aging Cell, Vol. 17, No. 4, e12790, 01.08.2018.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Glucocorticoid-mediated modulation of morphological changes associated with aging in microglia

AU - van Olst, Lynn

AU - Bielefeld, Pascal

AU - Fitzsimons, Carlos P

AU - de Vries, Helga E

AU - Schouten, Marijn

N1 - © 2018 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

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AB - Microglia dynamically adapt their morphology and function during increasing age. However, the mechanisms behind these changes are to date poorly understood. Glucocorticoids (GCs) are long known and utilized for their immunomodulatory actions and endogenous GC levels are described to alter with advancing age. We here tested the hypothesis that age-associated elevations in GC levels implicate microglia function and morphology. Our data indicate a decrease in microglial complexity and a concomitant increase in GC levels during aging. Interestingly, enhancing GC levels in young mice enhanced microglial ramifications, while the knockdown of the glucocorticoid receptor expression in old mice aggravated age-associated microglial amoebification. These data suggest that GCs increase ramification of hippocampal microglia and may modulate age-associated changes in microglial morphology.

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