Grey Matter Changes Associated with Heavy Cannabis Use: A Longitudinal sMRI Study

Laura Koenders, Janna Cousijn, Wilhelmina A M Vingerhoets, Wim van den Brink, Reinout W Wiers, Carin J Meijer, Marise W J Machielsen, Dick J Veltman, Anneke E Goudriaan, Lieuwe de Haan

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Cannabis is the most frequently used illicit drug worldwide. Cross-sectional neuroimaging studies suggest that chronic cannabis exposure and the development of cannabis use disorders may affect brain morphology. However, cross-sectional studies cannot make a conclusive distinction between cause and consequence and longitudinal neuroimaging studies are lacking. In this prospective study we investigate whether continued cannabis use and higher levels of cannabis exposure in young adults are associated with grey matter reductions. Heavy cannabis users (N = 20, age baseline M = 20.5, SD = 2.1) and non-cannabis using healthy controls (N = 22, age baseline M = 21.6, SD = 2.45) underwent a comprehensive psychological assessment and a T1- structural MRI scan at baseline and 3 years follow-up. Grey matter volumes (orbitofrontal cortex, anterior cingulate cortex, insula, striatum, thalamus, amygdala, hippocampus and cerebellum) were estimated using the software package SPM (VBM-8 module). Continued cannabis use did not have an effect on GM volume change at follow-up. Cross-sectional analyses at baseline and follow-up revealed consistent negative correlations between cannabis related problems and cannabis use (in grams) and regional GM volume of the left hippocampus, amygdala and superior temporal gyrus. These results suggests that small GM volumes in the medial temporal lobe are a risk factor for heavy cannabis use or that the effect of cannabis on GM reductions is limited to adolescence with no further damage of continued use after early adulthood. Long-term prospective studies starting in early adolescence are needed to reach final conclusions.

Original languageEnglish
Pages (from-to)e0152482
JournalPLoS ONE
Volume11
Issue number5
DOIs
Publication statusPublished - 2016

Cite this

Koenders, L., Cousijn, J., Vingerhoets, W. A. M., van den Brink, W., Wiers, R. W., Meijer, C. J., ... de Haan, L. (2016). Grey Matter Changes Associated with Heavy Cannabis Use: A Longitudinal sMRI Study. PLoS ONE, 11(5), e0152482. https://doi.org/10.1371/journal.pone.0152482
Koenders, Laura ; Cousijn, Janna ; Vingerhoets, Wilhelmina A M ; van den Brink, Wim ; Wiers, Reinout W ; Meijer, Carin J ; Machielsen, Marise W J ; Veltman, Dick J ; Goudriaan, Anneke E ; de Haan, Lieuwe. / Grey Matter Changes Associated with Heavy Cannabis Use : A Longitudinal sMRI Study. In: PLoS ONE. 2016 ; Vol. 11, No. 5. pp. e0152482.
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abstract = "Cannabis is the most frequently used illicit drug worldwide. Cross-sectional neuroimaging studies suggest that chronic cannabis exposure and the development of cannabis use disorders may affect brain morphology. However, cross-sectional studies cannot make a conclusive distinction between cause and consequence and longitudinal neuroimaging studies are lacking. In this prospective study we investigate whether continued cannabis use and higher levels of cannabis exposure in young adults are associated with grey matter reductions. Heavy cannabis users (N = 20, age baseline M = 20.5, SD = 2.1) and non-cannabis using healthy controls (N = 22, age baseline M = 21.6, SD = 2.45) underwent a comprehensive psychological assessment and a T1- structural MRI scan at baseline and 3 years follow-up. Grey matter volumes (orbitofrontal cortex, anterior cingulate cortex, insula, striatum, thalamus, amygdala, hippocampus and cerebellum) were estimated using the software package SPM (VBM-8 module). Continued cannabis use did not have an effect on GM volume change at follow-up. Cross-sectional analyses at baseline and follow-up revealed consistent negative correlations between cannabis related problems and cannabis use (in grams) and regional GM volume of the left hippocampus, amygdala and superior temporal gyrus. These results suggests that small GM volumes in the medial temporal lobe are a risk factor for heavy cannabis use or that the effect of cannabis on GM reductions is limited to adolescence with no further damage of continued use after early adulthood. Long-term prospective studies starting in early adolescence are needed to reach final conclusions.",
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Koenders, L, Cousijn, J, Vingerhoets, WAM, van den Brink, W, Wiers, RW, Meijer, CJ, Machielsen, MWJ, Veltman, DJ, Goudriaan, AE & de Haan, L 2016, 'Grey Matter Changes Associated with Heavy Cannabis Use: A Longitudinal sMRI Study' PLoS ONE, vol. 11, no. 5, pp. e0152482. https://doi.org/10.1371/journal.pone.0152482

Grey Matter Changes Associated with Heavy Cannabis Use : A Longitudinal sMRI Study. / Koenders, Laura; Cousijn, Janna; Vingerhoets, Wilhelmina A M; van den Brink, Wim; Wiers, Reinout W; Meijer, Carin J; Machielsen, Marise W J; Veltman, Dick J; Goudriaan, Anneke E; de Haan, Lieuwe.

In: PLoS ONE, Vol. 11, No. 5, 2016, p. e0152482.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Koenders, Laura

AU - Cousijn, Janna

AU - Vingerhoets, Wilhelmina A M

AU - van den Brink, Wim

AU - Wiers, Reinout W

AU - Meijer, Carin J

AU - Machielsen, Marise W J

AU - Veltman, Dick J

AU - Goudriaan, Anneke E

AU - de Haan, Lieuwe

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AB - Cannabis is the most frequently used illicit drug worldwide. Cross-sectional neuroimaging studies suggest that chronic cannabis exposure and the development of cannabis use disorders may affect brain morphology. However, cross-sectional studies cannot make a conclusive distinction between cause and consequence and longitudinal neuroimaging studies are lacking. In this prospective study we investigate whether continued cannabis use and higher levels of cannabis exposure in young adults are associated with grey matter reductions. Heavy cannabis users (N = 20, age baseline M = 20.5, SD = 2.1) and non-cannabis using healthy controls (N = 22, age baseline M = 21.6, SD = 2.45) underwent a comprehensive psychological assessment and a T1- structural MRI scan at baseline and 3 years follow-up. Grey matter volumes (orbitofrontal cortex, anterior cingulate cortex, insula, striatum, thalamus, amygdala, hippocampus and cerebellum) were estimated using the software package SPM (VBM-8 module). Continued cannabis use did not have an effect on GM volume change at follow-up. Cross-sectional analyses at baseline and follow-up revealed consistent negative correlations between cannabis related problems and cannabis use (in grams) and regional GM volume of the left hippocampus, amygdala and superior temporal gyrus. These results suggests that small GM volumes in the medial temporal lobe are a risk factor for heavy cannabis use or that the effect of cannabis on GM reductions is limited to adolescence with no further damage of continued use after early adulthood. Long-term prospective studies starting in early adolescence are needed to reach final conclusions.

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Koenders L, Cousijn J, Vingerhoets WAM, van den Brink W, Wiers RW, Meijer CJ et al. Grey Matter Changes Associated with Heavy Cannabis Use: A Longitudinal sMRI Study. PLoS ONE. 2016;11(5):e0152482. https://doi.org/10.1371/journal.pone.0152482