Growth factor quantification of Platelet-rich plasma in burn patients compared to matched healthy volunteers

Roos E. Marck, Kim L. M. Gardien, Marcel Vlig, Roelf S. Breederveld, Esther Middelkoop

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Platelet rich plasma (PRP) is blood plasma with a platelet concentration above baseline. When activated, PRP releases growth factors involved in all stages of wound healing, potentially boosting the healing process. To expand our knowledge of the effectiveness of PRP, it is crucial to know the content and composition of PRP products. In this study, growth factor quantification measurements of PRP from burn patients and gender-and age-matched controls were performed. The PRP of burn patients showed levels of growth factors comparable to those of the PRP of healthy volunteers. Considerable intra-individual variation in growth factor content was found. However, a correlation was found between the platelet count of the PRP and most of the growth factors measured.
Original languageEnglish
Article number288
JournalInternational Journal of Molecular Sciences
Volume20
Issue number2
DOIs
Publication statusPublished - 2 Jan 2019

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