Growth throughout childhood of children born growth restricted

Fenny Beukers, Joost Rotteveel, Mirjam M. Van Weissenbruch, Wessel Ganzevoort, Johannes B. Van Goudoever, Aleid G. Van Wassenaer-Leemhuis

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objective Many studies that examine growth in growth-restricted children at birth do not discriminate between fetal growth restriction (FGR) and small for gestational age (SGA). These terms however are not synonymous. In SGA, stunting and increased weight gain have been reported. We do not know if this holds true for FGR. Our aim was to study postnatal growth until age 12.5 €...years in a cohort of children born FGR due to early onset placental insufficiency, and its relation to FGR severity. Design Prospective cohort study, follow-up of an antenatal randomised controlled trial in two tertiary centres. Patients Children aged 12.5 €...years born after FGR, with mothers who had severe early onset hypertensive pregnancy disorders (N=96). Main outcome measures Anthropometry at age 12.5 €...years in SD scores (SDS). Results Mean height SDS (SD) corrected for target height was '0.09 (0.94), mean body mass index (BMI) SDS was 0.00 (1.16) and mean head circumference SDS was -0.37 (1.11). Catch-up growth was at fastest rate between term age and 3 €...months and similar for height (0.55 SDS/months) and weight (0.49 SDS/months). Neither FGR severity nor gestational age was related to height and BMI at age 12.5 €...years. Conclusions Children born growth restricted due to early onset placental insufficiency have height and BMI scores comparable to their age-matched peers at age 12.5 €...years. FGR severity was not related to height and BMI at age 12.5 €...years. These reassuring results differ from most studies that examine SGA children.

Original languageEnglish
Pages (from-to)735-741
Number of pages7
JournalArchives of Disease in Childhood
Volume102
Issue number8
DOIs
Publication statusPublished - 1 Aug 2017

Cite this

Beukers, Fenny ; Rotteveel, Joost ; Van Weissenbruch, Mirjam M. ; Ganzevoort, Wessel ; Van Goudoever, Johannes B. ; Van Wassenaer-Leemhuis, Aleid G. / Growth throughout childhood of children born growth restricted. In: Archives of Disease in Childhood. 2017 ; Vol. 102, No. 8. pp. 735-741.
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title = "Growth throughout childhood of children born growth restricted",
abstract = "Objective Many studies that examine growth in growth-restricted children at birth do not discriminate between fetal growth restriction (FGR) and small for gestational age (SGA). These terms however are not synonymous. In SGA, stunting and increased weight gain have been reported. We do not know if this holds true for FGR. Our aim was to study postnatal growth until age 12.5 €...years in a cohort of children born FGR due to early onset placental insufficiency, and its relation to FGR severity. Design Prospective cohort study, follow-up of an antenatal randomised controlled trial in two tertiary centres. Patients Children aged 12.5 €...years born after FGR, with mothers who had severe early onset hypertensive pregnancy disorders (N=96). Main outcome measures Anthropometry at age 12.5 €...years in SD scores (SDS). Results Mean height SDS (SD) corrected for target height was '0.09 (0.94), mean body mass index (BMI) SDS was 0.00 (1.16) and mean head circumference SDS was -0.37 (1.11). Catch-up growth was at fastest rate between term age and 3 €...months and similar for height (0.55 SDS/months) and weight (0.49 SDS/months). Neither FGR severity nor gestational age was related to height and BMI at age 12.5 €...years. Conclusions Children born growth restricted due to early onset placental insufficiency have height and BMI scores comparable to their age-matched peers at age 12.5 €...years. FGR severity was not related to height and BMI at age 12.5 €...years. These reassuring results differ from most studies that examine SGA children.",
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Growth throughout childhood of children born growth restricted. / Beukers, Fenny; Rotteveel, Joost; Van Weissenbruch, Mirjam M.; Ganzevoort, Wessel; Van Goudoever, Johannes B.; Van Wassenaer-Leemhuis, Aleid G.

In: Archives of Disease in Childhood, Vol. 102, No. 8, 01.08.2017, p. 735-741.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Growth throughout childhood of children born growth restricted

AU - Beukers, Fenny

AU - Rotteveel, Joost

AU - Van Weissenbruch, Mirjam M.

AU - Ganzevoort, Wessel

AU - Van Goudoever, Johannes B.

AU - Van Wassenaer-Leemhuis, Aleid G.

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Objective Many studies that examine growth in growth-restricted children at birth do not discriminate between fetal growth restriction (FGR) and small for gestational age (SGA). These terms however are not synonymous. In SGA, stunting and increased weight gain have been reported. We do not know if this holds true for FGR. Our aim was to study postnatal growth until age 12.5 €...years in a cohort of children born FGR due to early onset placental insufficiency, and its relation to FGR severity. Design Prospective cohort study, follow-up of an antenatal randomised controlled trial in two tertiary centres. Patients Children aged 12.5 €...years born after FGR, with mothers who had severe early onset hypertensive pregnancy disorders (N=96). Main outcome measures Anthropometry at age 12.5 €...years in SD scores (SDS). Results Mean height SDS (SD) corrected for target height was '0.09 (0.94), mean body mass index (BMI) SDS was 0.00 (1.16) and mean head circumference SDS was -0.37 (1.11). Catch-up growth was at fastest rate between term age and 3 €...months and similar for height (0.55 SDS/months) and weight (0.49 SDS/months). Neither FGR severity nor gestational age was related to height and BMI at age 12.5 €...years. Conclusions Children born growth restricted due to early onset placental insufficiency have height and BMI scores comparable to their age-matched peers at age 12.5 €...years. FGR severity was not related to height and BMI at age 12.5 €...years. These reassuring results differ from most studies that examine SGA children.

AB - Objective Many studies that examine growth in growth-restricted children at birth do not discriminate between fetal growth restriction (FGR) and small for gestational age (SGA). These terms however are not synonymous. In SGA, stunting and increased weight gain have been reported. We do not know if this holds true for FGR. Our aim was to study postnatal growth until age 12.5 €...years in a cohort of children born FGR due to early onset placental insufficiency, and its relation to FGR severity. Design Prospective cohort study, follow-up of an antenatal randomised controlled trial in two tertiary centres. Patients Children aged 12.5 €...years born after FGR, with mothers who had severe early onset hypertensive pregnancy disorders (N=96). Main outcome measures Anthropometry at age 12.5 €...years in SD scores (SDS). Results Mean height SDS (SD) corrected for target height was '0.09 (0.94), mean body mass index (BMI) SDS was 0.00 (1.16) and mean head circumference SDS was -0.37 (1.11). Catch-up growth was at fastest rate between term age and 3 €...months and similar for height (0.55 SDS/months) and weight (0.49 SDS/months). Neither FGR severity nor gestational age was related to height and BMI at age 12.5 €...years. Conclusions Children born growth restricted due to early onset placental insufficiency have height and BMI scores comparable to their age-matched peers at age 12.5 €...years. FGR severity was not related to height and BMI at age 12.5 €...years. These reassuring results differ from most studies that examine SGA children.

KW - Child growth

KW - Fetal growth restriction

KW - General Paediatrics

KW - Neonatology

KW - Placental insufficiency

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U2 - 10.1136/archdischild-2016-312003

DO - 10.1136/archdischild-2016-312003

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JF - Archives of Disease in Childhood

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