Guideline adherence and clinical relevance of laboratory investigations during follow-up in paediatric coeliac disease: A Dutch single-centre cohort study

Michael W. van Kalleveen*, Tim C. Dykstra, Tim G.J. de Meij, Frans B. Plötz

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Aim: Dutch national guidelines on follow-up of paediatric celiac disease (CD) are available. The primary aim was to evaluate guideline adherence by paediatricians during follow-up. The secondary aim was to determine the clinical relevance and diagnostic yield of routine laboratory tests suggested by these guidelines. Methods: A retrospective, single-centre, cohort study was performed in paediatric CD patients who visited Tergooi Hospital, the Netherlands, between January 2017 and December 2019, with follow-up of at least twelve months after diagnosis. We analysed guideline adherence, number of outpatient visits and all laboratory data. Results: We included 91 CD children with a median follow-up of 4.0 years (range 1–16 years) and 162 follow-up visits. Strict adherence amongst paediatricians during follow-up was 8.0% (13/162 cases). A total of 1570 laboratory tests were performed of which 45.4% (713/1570) was in strict compliance with the Dutch national guidelines. Clinically relevant deviations were observed in 5.3% of requested laboratory tests. Conclusion: Strict guideless adherence amongst paediatricians in follow-up of paediatric CD was low and the clinical relevance of the suggested routine laboratory tests is limited. This underlines the increasing notion that evidence-based guidelines on follow-up of CD are warranted.

Original languageEnglish
Pages (from-to)2641-2647
Number of pages7
JournalActa Paediatrica, International Journal of Paediatrics
Issue number9
Publication statusPublished - Sep 2021

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