Healthy minds 0–100 years: Optimising the use of European brain imaging cohorts (“Lifebrain”)

Kristine B. Walhovd, Anders M. Fjell, René Westerhausen, Lars Nyberg, Klaus P. Ebmeier*, Ulman Lindenberger, David Bartrés-Faz, William F.C. Baaré, Hartwig R. Siebner, Richard Henson, Christian A. Drevon, Gun Peggy Strømstad Knudsen, Isabelle Budin Ljøsne, Brenda W.J.H. Penninx, Paolo Ghisletta, Ole Rogeberg, Lorraine Tyler, Lars Bertram, Lifebrain Consortium

*Corresponding author for this work

Research output: Contribution to journalShort surveyAcademicpeer-review

Abstract

The main objective of “Lifebrain” is to identify the determinants of brain, cognitive and mental (BCM) health at different stages of life. By integrating, harmonising and enriching major European neuroimaging studies across the life span, we will merge fine-grained BCM health measures of more than 5000 individuals. Longitudinal brain imaging, genetic and health data are available for a major part, as well as cognitive and mental health measures for the broader cohorts, exceeding 27,000 examinations in total. By linking these data to other databases and biobanks, including birth registries, national and regional archives, and by enriching them with a new online data collection and novel measures, we will address the risk factors and protective factors of BCM health. We will identify pathways through which risk and protective factors work and their moderators. Exploiting existing European infrastructures and initiatives, we hope to make major conceptual, methodological and analytical contributions towards large integrative cohorts and their efficient exploitation. We will thus provide novel information on BCM health maintenance, as well as the onset and course of BCM disorders. This will lay a foundation for earlier diagnosis of brain disorders, aberrant development and decline of BCM health, and translate into future preventive and therapeutic strategies. Aiming to improve clinical practice and public health we will work with stakeholders and health authorities, and thus provide the evidence base for prevention and intervention.

Original languageEnglish
Pages (from-to)47-56
Number of pages10
JournalEuropean Psychiatry
Volume50
DOIs
Publication statusPublished - 1 Apr 2018

Cite this

Walhovd, K. B., Fjell, A. M., Westerhausen, R., Nyberg, L., Ebmeier, K. P., Lindenberger, U., ... Lifebrain Consortium (2018). Healthy minds 0–100 years: Optimising the use of European brain imaging cohorts (“Lifebrain”). European Psychiatry, 50, 47-56. https://doi.org/10.1016/j.eurpsy.2017.12.006