Heart rate variability in the conscious dog signifi- cantly depends on duration of diastole

P. L M Kerkhof, H. L M Pijnenburg, J. K J Li

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Heart Rate (HR) Variability (V) analysis provides information about cardiac regulation. Although HRV affects pump function on a beat-to-beat basis, no systematic study addresses the relative contribution of systole (S) and diastole (D). Thus, we analyzed the duration (T) by determining TS and TD in 2 conscious dogs instrumented with aortic flow probe. We selected 5 min epochs at rest (R) and 20 ug/kg.min dobutamine (Do) or 3 ug/kg.min medetomidine (M). V ofV of TS and TD are expressed as the T of beat n divided by the previous (n-1), and presented as mean, standard deviation (SD), with absolute values in brackets: TS/SD [ms] TD/SD [ms] HR/SD [bpm] R 1.000/0.024 1.083/0.444 1.048/0.326 [0.180/0.004] [0.536/0.174] [88.360/19.379] Do 1.000/0.027 1.002/0.082 1.002/0.056 [0.156/0.012] [0.335/0.074] [125.006/17.641] M 1.011/0.152 1.925/2.059 1.599/1.368 [0.203/0.020] [1.706/0.937] [44.816/29.319] Conclusions: V of TD is more pronounced than V in S (differences significant at p<0.05), suggesting that beat-to-beat variations in both preload (related to filling time) and afterload (due to exponential decrease of aortic pressure) are contributing factors and may have consequences in interpreting the regulation of ventricular function in terms of HRV.

LanguageEnglish
JournalFASEB Journal
Volume11
Issue number3
Publication statusPublished - 1 Dec 1997

Cite this

@article{a3dd3ae479df4edfb00481ac0655431c,
title = "Heart rate variability in the conscious dog signifi- cantly depends on duration of diastole",
abstract = "Heart Rate (HR) Variability (V) analysis provides information about cardiac regulation. Although HRV affects pump function on a beat-to-beat basis, no systematic study addresses the relative contribution of systole (S) and diastole (D). Thus, we analyzed the duration (T) by determining TS and TD in 2 conscious dogs instrumented with aortic flow probe. We selected 5 min epochs at rest (R) and 20 ug/kg.min dobutamine (Do) or 3 ug/kg.min medetomidine (M). V ofV of TS and TD are expressed as the T of beat n divided by the previous (n-1), and presented as mean, standard deviation (SD), with absolute values in brackets: TS/SD [ms] TD/SD [ms] HR/SD [bpm] R 1.000/0.024 1.083/0.444 1.048/0.326 [0.180/0.004] [0.536/0.174] [88.360/19.379] Do 1.000/0.027 1.002/0.082 1.002/0.056 [0.156/0.012] [0.335/0.074] [125.006/17.641] M 1.011/0.152 1.925/2.059 1.599/1.368 [0.203/0.020] [1.706/0.937] [44.816/29.319] Conclusions: V of TD is more pronounced than V in S (differences significant at p<0.05), suggesting that beat-to-beat variations in both preload (related to filling time) and afterload (due to exponential decrease of aortic pressure) are contributing factors and may have consequences in interpreting the regulation of ventricular function in terms of HRV.",
author = "Kerkhof, {P. L M} and Pijnenburg, {H. L M} and Li, {J. K J}",
year = "1997",
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language = "English",
volume = "11",
journal = "FASEB Journal",
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Heart rate variability in the conscious dog signifi- cantly depends on duration of diastole. / Kerkhof, P. L M; Pijnenburg, H. L M; Li, J. K J.

In: FASEB Journal, Vol. 11, No. 3, 01.12.1997.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Heart rate variability in the conscious dog signifi- cantly depends on duration of diastole

AU - Kerkhof, P. L M

AU - Pijnenburg, H. L M

AU - Li, J. K J

PY - 1997/12/1

Y1 - 1997/12/1

N2 - Heart Rate (HR) Variability (V) analysis provides information about cardiac regulation. Although HRV affects pump function on a beat-to-beat basis, no systematic study addresses the relative contribution of systole (S) and diastole (D). Thus, we analyzed the duration (T) by determining TS and TD in 2 conscious dogs instrumented with aortic flow probe. We selected 5 min epochs at rest (R) and 20 ug/kg.min dobutamine (Do) or 3 ug/kg.min medetomidine (M). V ofV of TS and TD are expressed as the T of beat n divided by the previous (n-1), and presented as mean, standard deviation (SD), with absolute values in brackets: TS/SD [ms] TD/SD [ms] HR/SD [bpm] R 1.000/0.024 1.083/0.444 1.048/0.326 [0.180/0.004] [0.536/0.174] [88.360/19.379] Do 1.000/0.027 1.002/0.082 1.002/0.056 [0.156/0.012] [0.335/0.074] [125.006/17.641] M 1.011/0.152 1.925/2.059 1.599/1.368 [0.203/0.020] [1.706/0.937] [44.816/29.319] Conclusions: V of TD is more pronounced than V in S (differences significant at p<0.05), suggesting that beat-to-beat variations in both preload (related to filling time) and afterload (due to exponential decrease of aortic pressure) are contributing factors and may have consequences in interpreting the regulation of ventricular function in terms of HRV.

AB - Heart Rate (HR) Variability (V) analysis provides information about cardiac regulation. Although HRV affects pump function on a beat-to-beat basis, no systematic study addresses the relative contribution of systole (S) and diastole (D). Thus, we analyzed the duration (T) by determining TS and TD in 2 conscious dogs instrumented with aortic flow probe. We selected 5 min epochs at rest (R) and 20 ug/kg.min dobutamine (Do) or 3 ug/kg.min medetomidine (M). V ofV of TS and TD are expressed as the T of beat n divided by the previous (n-1), and presented as mean, standard deviation (SD), with absolute values in brackets: TS/SD [ms] TD/SD [ms] HR/SD [bpm] R 1.000/0.024 1.083/0.444 1.048/0.326 [0.180/0.004] [0.536/0.174] [88.360/19.379] Do 1.000/0.027 1.002/0.082 1.002/0.056 [0.156/0.012] [0.335/0.074] [125.006/17.641] M 1.011/0.152 1.925/2.059 1.599/1.368 [0.203/0.020] [1.706/0.937] [44.816/29.319] Conclusions: V of TD is more pronounced than V in S (differences significant at p<0.05), suggesting that beat-to-beat variations in both preload (related to filling time) and afterload (due to exponential decrease of aortic pressure) are contributing factors and may have consequences in interpreting the regulation of ventricular function in terms of HRV.

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M3 - Article

VL - 11

JO - FASEB Journal

T2 - FASEB Journal

JF - FASEB Journal

SN - 0892-6638

IS - 3

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