Heart transplantation survival and sex-related differences

Martina Previato, Elena Osto, Peter L. M. Kerkhof, Gareth Parry, Francesco Tona

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Abstract

Orthotopic heart transplantation (OHT) is the “gold standard” treatment for patients with end-stage heart failure, with approximately 5000 transplants performed each year worldwide. Heart transplantation survival rates have progressively improved at all time points, despite an increase in donor and recipient age and comorbidity and greater recipient urgency; according to the registry of the International Society of Heart and Lung Transplantation (ISHLT), the median survival of patients posttransplantation is currently 12.2 years. Long-term survival is sub-optimal, and outcomes after OHT remain constrained by the development of acute rejection and cardiac allograft vasculopathy (CAV). Moreover, donor organs are in short supply, making optimal organ utilization an ongoing priority. For these reasons, substantial interest continues to exist in identifying factors portending increased survival and improved organ utilization.
Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages379-388
Number of pages10
Volume1065
DOIs
Publication statusPublished - 2018

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Cite this

Previato, M., Osto, E., Kerkhof, P. L. M., Parry, G., & Tona, F. (2018). Heart transplantation survival and sex-related differences. In Advances in Experimental Medicine and Biology (Vol. 1065, pp. 379-388). (Advances in Experimental Medicine and Biology). Springer New York LLC. https://doi.org/10.1007/978-3-319-77932-4_24
Previato, Martina ; Osto, Elena ; Kerkhof, Peter L. M. ; Parry, Gareth ; Tona, Francesco. / Heart transplantation survival and sex-related differences. Advances in Experimental Medicine and Biology. Vol. 1065 Springer New York LLC, 2018. pp. 379-388 (Advances in Experimental Medicine and Biology).
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author = "Martina Previato and Elena Osto and Kerkhof, {Peter L. M.} and Gareth Parry and Francesco Tona",
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Previato, M, Osto, E, Kerkhof, PLM, Parry, G & Tona, F 2018, Heart transplantation survival and sex-related differences. in Advances in Experimental Medicine and Biology. vol. 1065, Advances in Experimental Medicine and Biology, Springer New York LLC, pp. 379-388. https://doi.org/10.1007/978-3-319-77932-4_24

Heart transplantation survival and sex-related differences. / Previato, Martina; Osto, Elena; Kerkhof, Peter L. M.; Parry, Gareth; Tona, Francesco.

Advances in Experimental Medicine and Biology. Vol. 1065 Springer New York LLC, 2018. p. 379-388 (Advances in Experimental Medicine and Biology).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

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AB - Orthotopic heart transplantation (OHT) is the “gold standard” treatment for patients with end-stage heart failure, with approximately 5000 transplants performed each year worldwide. Heart transplantation survival rates have progressively improved at all time points, despite an increase in donor and recipient age and comorbidity and greater recipient urgency; according to the registry of the International Society of Heart and Lung Transplantation (ISHLT), the median survival of patients posttransplantation is currently 12.2 years. Long-term survival is sub-optimal, and outcomes after OHT remain constrained by the development of acute rejection and cardiac allograft vasculopathy (CAV). Moreover, donor organs are in short supply, making optimal organ utilization an ongoing priority. For these reasons, substantial interest continues to exist in identifying factors portending increased survival and improved organ utilization.

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BT - Advances in Experimental Medicine and Biology

PB - Springer New York LLC

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Previato M, Osto E, Kerkhof PLM, Parry G, Tona F. Heart transplantation survival and sex-related differences. In Advances in Experimental Medicine and Biology. Vol. 1065. Springer New York LLC. 2018. p. 379-388. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-3-319-77932-4_24