High HPA-axis activation disrupts the link between liking and wanting with liking and wanting related brain signaling

Jurriaan M Born, Mieke J I Martens, Femke Rutters, Sofie G T Lemmens, Rainer Goebel, Margriet S Westerterp-Plantenga

    Research output: Contribution to journalArticleAcademicpeer-review

    Abstract

    BACKGROUND: Eating behavior changes under stress, i.e. during high HPA-axis activation.

    AIM: Assessment of effects of high versus low HPA-axis activation on liking and wanting related brain signaling in relevant regions.

    METHODS: 15 female subjects (21.5±0.4 years, BMI=22.2±0.4) completed fMRI scans on 2 days, in a fasted as well as a satiated condition on each day. The days were sorted by HPA-axis activation, resulting in two sufficiently separated HPA-axis states which were statistically confirmed (p<.05). During scans, subjects rated liking and wanting for food images; wanting indicated food choice for the subsequent meal. Energy-intake, hunger and fullness were additionally recorded.

    RESULTS: Hunger changed significantly over the meal (p<.001). Energy intake was lower during the second meal (p<.001). Behavioral wanting was lower after breakfast (p<.01), behavioral liking did not change. During low HPA-activation, liking task related signaling (TRS) pre-meal in the anterior insula predicted behavioral liking, wanting TRS in the anterior insula, nucleus accumbens and thalamus predicted behavioral wanting. During high HPA-activation, these relationships were not present pre-meal, but post-meal behavioral liking was predicted in the nucleus accumbens and wanting in the caudate.

    CONCLUSION: High HPA-axis activation disrupted and redirected the connection of behavioral liking/wanting with the specifically associated brain signaling in relevant regions.

    Original languageEnglish
    Pages (from-to)321-4
    Number of pages4
    JournalPhysiology and Behavior
    Volume105
    Issue number2
    DOIs
    Publication statusPublished - 18 Jan 2012

    Cite this

    Born, Jurriaan M ; Martens, Mieke J I ; Rutters, Femke ; Lemmens, Sofie G T ; Goebel, Rainer ; Westerterp-Plantenga, Margriet S. / High HPA-axis activation disrupts the link between liking and wanting with liking and wanting related brain signaling. In: Physiology and Behavior. 2012 ; Vol. 105, No. 2. pp. 321-4.
    @article{2f825a3dc93740028600eb9a40c2b597,
    title = "High HPA-axis activation disrupts the link between liking and wanting with liking and wanting related brain signaling",
    abstract = "BACKGROUND: Eating behavior changes under stress, i.e. during high HPA-axis activation.AIM: Assessment of effects of high versus low HPA-axis activation on liking and wanting related brain signaling in relevant regions.METHODS: 15 female subjects (21.5±0.4 years, BMI=22.2±0.4) completed fMRI scans on 2 days, in a fasted as well as a satiated condition on each day. The days were sorted by HPA-axis activation, resulting in two sufficiently separated HPA-axis states which were statistically confirmed (p<.05). During scans, subjects rated liking and wanting for food images; wanting indicated food choice for the subsequent meal. Energy-intake, hunger and fullness were additionally recorded.RESULTS: Hunger changed significantly over the meal (p<.001). Energy intake was lower during the second meal (p<.001). Behavioral wanting was lower after breakfast (p<.01), behavioral liking did not change. During low HPA-activation, liking task related signaling (TRS) pre-meal in the anterior insula predicted behavioral liking, wanting TRS in the anterior insula, nucleus accumbens and thalamus predicted behavioral wanting. During high HPA-activation, these relationships were not present pre-meal, but post-meal behavioral liking was predicted in the nucleus accumbens and wanting in the caudate.CONCLUSION: High HPA-axis activation disrupted and redirected the connection of behavioral liking/wanting with the specifically associated brain signaling in relevant regions.",
    keywords = "Analysis of Variance, Brain/blood supply, Choice Behavior/physiology, Eating, Emotions/physiology, Energy Intake/physiology, Fasting/physiology, Female, Food Preferences/physiology, Humans, Hydrocortisone/blood, Image Processing, Computer-Assisted, Linear Models, Magnetic Resonance Imaging/methods, Motivation/physiology, Oxygen/blood, Signal Transduction, Young Adult",
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    High HPA-axis activation disrupts the link between liking and wanting with liking and wanting related brain signaling. / Born, Jurriaan M; Martens, Mieke J I; Rutters, Femke; Lemmens, Sofie G T; Goebel, Rainer; Westerterp-Plantenga, Margriet S.

    In: Physiology and Behavior, Vol. 105, No. 2, 18.01.2012, p. 321-4.

    Research output: Contribution to journalArticleAcademicpeer-review

    TY - JOUR

    T1 - High HPA-axis activation disrupts the link between liking and wanting with liking and wanting related brain signaling

    AU - Born, Jurriaan M

    AU - Martens, Mieke J I

    AU - Rutters, Femke

    AU - Lemmens, Sofie G T

    AU - Goebel, Rainer

    AU - Westerterp-Plantenga, Margriet S

    N1 - Copyright © 2011 Elsevier Inc. All rights reserved.

    PY - 2012/1/18

    Y1 - 2012/1/18

    N2 - BACKGROUND: Eating behavior changes under stress, i.e. during high HPA-axis activation.AIM: Assessment of effects of high versus low HPA-axis activation on liking and wanting related brain signaling in relevant regions.METHODS: 15 female subjects (21.5±0.4 years, BMI=22.2±0.4) completed fMRI scans on 2 days, in a fasted as well as a satiated condition on each day. The days were sorted by HPA-axis activation, resulting in two sufficiently separated HPA-axis states which were statistically confirmed (p<.05). During scans, subjects rated liking and wanting for food images; wanting indicated food choice for the subsequent meal. Energy-intake, hunger and fullness were additionally recorded.RESULTS: Hunger changed significantly over the meal (p<.001). Energy intake was lower during the second meal (p<.001). Behavioral wanting was lower after breakfast (p<.01), behavioral liking did not change. During low HPA-activation, liking task related signaling (TRS) pre-meal in the anterior insula predicted behavioral liking, wanting TRS in the anterior insula, nucleus accumbens and thalamus predicted behavioral wanting. During high HPA-activation, these relationships were not present pre-meal, but post-meal behavioral liking was predicted in the nucleus accumbens and wanting in the caudate.CONCLUSION: High HPA-axis activation disrupted and redirected the connection of behavioral liking/wanting with the specifically associated brain signaling in relevant regions.

    AB - BACKGROUND: Eating behavior changes under stress, i.e. during high HPA-axis activation.AIM: Assessment of effects of high versus low HPA-axis activation on liking and wanting related brain signaling in relevant regions.METHODS: 15 female subjects (21.5±0.4 years, BMI=22.2±0.4) completed fMRI scans on 2 days, in a fasted as well as a satiated condition on each day. The days were sorted by HPA-axis activation, resulting in two sufficiently separated HPA-axis states which were statistically confirmed (p<.05). During scans, subjects rated liking and wanting for food images; wanting indicated food choice for the subsequent meal. Energy-intake, hunger and fullness were additionally recorded.RESULTS: Hunger changed significantly over the meal (p<.001). Energy intake was lower during the second meal (p<.001). Behavioral wanting was lower after breakfast (p<.01), behavioral liking did not change. During low HPA-activation, liking task related signaling (TRS) pre-meal in the anterior insula predicted behavioral liking, wanting TRS in the anterior insula, nucleus accumbens and thalamus predicted behavioral wanting. During high HPA-activation, these relationships were not present pre-meal, but post-meal behavioral liking was predicted in the nucleus accumbens and wanting in the caudate.CONCLUSION: High HPA-axis activation disrupted and redirected the connection of behavioral liking/wanting with the specifically associated brain signaling in relevant regions.

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    KW - Brain/blood supply

    KW - Choice Behavior/physiology

    KW - Eating

    KW - Emotions/physiology

    KW - Energy Intake/physiology

    KW - Fasting/physiology

    KW - Female

    KW - Food Preferences/physiology

    KW - Humans

    KW - Hydrocortisone/blood

    KW - Image Processing, Computer-Assisted

    KW - Linear Models

    KW - Magnetic Resonance Imaging/methods

    KW - Motivation/physiology

    KW - Oxygen/blood

    KW - Signal Transduction

    KW - Young Adult

    U2 - 10.1016/j.physbeh.2011.08.015

    DO - 10.1016/j.physbeh.2011.08.015

    M3 - Article

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    SP - 321

    EP - 324

    JO - Physiology and Behavior

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    SN - 0031-9384

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    ER -