High HPA-axis activation disrupts the link between liking and wanting with liking and wanting related brain signaling

Jurriaan M Born; Mieke J I Martens; Femke Rutters; Sofie G T Lemmens; Rainer Goebel; Margriet S Westerterp-Plantenga

doi:10.1016/j.physbeh.2011.08.015

High HPA-axis activation disrupts the link between liking and wanting with liking and wanting related brain signaling

Jurriaan M Born, Mieke J I Martens, Femke Rutters, Sofie G T Lemmens, Rainer Goebel, Margriet S Westerterp-Plantenga

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Eating behavior changes under stress, i.e. during high HPA-axis activation.

AIM: Assessment of effects of high versus low HPA-axis activation on liking and wanting related brain signaling in relevant regions.

METHODS: 15 female subjects (21.5±0.4 years, BMI=22.2±0.4) completed fMRI scans on 2 days, in a fasted as well as a satiated condition on each day. The days were sorted by HPA-axis activation, resulting in two sufficiently separated HPA-axis states which were statistically confirmed (p<.05). During scans, subjects rated liking and wanting for food images; wanting indicated food choice for the subsequent meal. Energy-intake, hunger and fullness were additionally recorded.

RESULTS: Hunger changed significantly over the meal (p<.001). Energy intake was lower during the second meal (p<.001). Behavioral wanting was lower after breakfast (p<.01), behavioral liking did not change. During low HPA-activation, liking task related signaling (TRS) pre-meal in the anterior insula predicted behavioral liking, wanting TRS in the anterior insula, nucleus accumbens and thalamus predicted behavioral wanting. During high HPA-activation, these relationships were not present pre-meal, but post-meal behavioral liking was predicted in the nucleus accumbens and wanting in the caudate.

CONCLUSION: High HPA-axis activation disrupted and redirected the connection of behavioral liking/wanting with the specifically associated brain signaling in relevant regions.

Original language	English
Pages (from-to)	321-4
Number of pages	4
Journal	Physiology and Behavior
Volume	105
Issue number	2
DOIs	https://doi.org/10.1016/j.physbeh.2011.08.015
Publication status	Published - 18 Jan 2012

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10.1016/j.physbeh.2011.08.015

Cite this

@article{2f825a3dc93740028600eb9a40c2b597,

title = "High HPA-axis activation disrupts the link between liking and wanting with liking and wanting related brain signaling",

abstract = "BACKGROUND: Eating behavior changes under stress, i.e. during high HPA-axis activation.AIM: Assessment of effects of high versus low HPA-axis activation on liking and wanting related brain signaling in relevant regions.METHODS: 15 female subjects (21.5±0.4 years, BMI=22.2±0.4) completed fMRI scans on 2 days, in a fasted as well as a satiated condition on each day. The days were sorted by HPA-axis activation, resulting in two sufficiently separated HPA-axis states which were statistically confirmed (p<.05). During scans, subjects rated liking and wanting for food images; wanting indicated food choice for the subsequent meal. Energy-intake, hunger and fullness were additionally recorded.RESULTS: Hunger changed significantly over the meal (p<.001). Energy intake was lower during the second meal (p<.001). Behavioral wanting was lower after breakfast (p<.01), behavioral liking did not change. During low HPA-activation, liking task related signaling (TRS) pre-meal in the anterior insula predicted behavioral liking, wanting TRS in the anterior insula, nucleus accumbens and thalamus predicted behavioral wanting. During high HPA-activation, these relationships were not present pre-meal, but post-meal behavioral liking was predicted in the nucleus accumbens and wanting in the caudate.CONCLUSION: High HPA-axis activation disrupted and redirected the connection of behavioral liking/wanting with the specifically associated brain signaling in relevant regions.",

keywords = "Analysis of Variance, Brain/blood supply, Choice Behavior/physiology, Eating, Emotions/physiology, Energy Intake/physiology, Fasting/physiology, Female, Food Preferences/physiology, Humans, Hydrocortisone/blood, Image Processing, Computer-Assisted, Linear Models, Magnetic Resonance Imaging/methods, Motivation/physiology, Oxygen/blood, Signal Transduction, Young Adult",

author = "Born, {Jurriaan M} and Martens, {Mieke J I} and Femke Rutters and Lemmens, {Sofie G T} and Rainer Goebel and Westerterp-Plantenga, {Margriet S}",

year = "2012",

month = jan,

day = "18",

doi = "10.1016/j.physbeh.2011.08.015",

language = "English",

volume = "105",

pages = "321--4",

journal = "Physiology and Behavior",

issn = "0031-9384",

publisher = "Elsevier Inc.",

number = "2",

}

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T1 - High HPA-axis activation disrupts the link between liking and wanting with liking and wanting related brain signaling

AU - Born, Jurriaan M

AU - Martens, Mieke J I

AU - Rutters, Femke

AU - Lemmens, Sofie G T

AU - Goebel, Rainer

AU - Westerterp-Plantenga, Margriet S

PY - 2012/1/18

Y1 - 2012/1/18

N2 - BACKGROUND: Eating behavior changes under stress, i.e. during high HPA-axis activation.AIM: Assessment of effects of high versus low HPA-axis activation on liking and wanting related brain signaling in relevant regions.METHODS: 15 female subjects (21.5±0.4 years, BMI=22.2±0.4) completed fMRI scans on 2 days, in a fasted as well as a satiated condition on each day. The days were sorted by HPA-axis activation, resulting in two sufficiently separated HPA-axis states which were statistically confirmed (p<.05). During scans, subjects rated liking and wanting for food images; wanting indicated food choice for the subsequent meal. Energy-intake, hunger and fullness were additionally recorded.RESULTS: Hunger changed significantly over the meal (p<.001). Energy intake was lower during the second meal (p<.001). Behavioral wanting was lower after breakfast (p<.01), behavioral liking did not change. During low HPA-activation, liking task related signaling (TRS) pre-meal in the anterior insula predicted behavioral liking, wanting TRS in the anterior insula, nucleus accumbens and thalamus predicted behavioral wanting. During high HPA-activation, these relationships were not present pre-meal, but post-meal behavioral liking was predicted in the nucleus accumbens and wanting in the caudate.CONCLUSION: High HPA-axis activation disrupted and redirected the connection of behavioral liking/wanting with the specifically associated brain signaling in relevant regions.

AB - BACKGROUND: Eating behavior changes under stress, i.e. during high HPA-axis activation.AIM: Assessment of effects of high versus low HPA-axis activation on liking and wanting related brain signaling in relevant regions.METHODS: 15 female subjects (21.5±0.4 years, BMI=22.2±0.4) completed fMRI scans on 2 days, in a fasted as well as a satiated condition on each day. The days were sorted by HPA-axis activation, resulting in two sufficiently separated HPA-axis states which were statistically confirmed (p<.05). During scans, subjects rated liking and wanting for food images; wanting indicated food choice for the subsequent meal. Energy-intake, hunger and fullness were additionally recorded.RESULTS: Hunger changed significantly over the meal (p<.001). Energy intake was lower during the second meal (p<.001). Behavioral wanting was lower after breakfast (p<.01), behavioral liking did not change. During low HPA-activation, liking task related signaling (TRS) pre-meal in the anterior insula predicted behavioral liking, wanting TRS in the anterior insula, nucleus accumbens and thalamus predicted behavioral wanting. During high HPA-activation, these relationships were not present pre-meal, but post-meal behavioral liking was predicted in the nucleus accumbens and wanting in the caudate.CONCLUSION: High HPA-axis activation disrupted and redirected the connection of behavioral liking/wanting with the specifically associated brain signaling in relevant regions.

KW - Analysis of Variance

KW - Brain/blood supply

KW - Choice Behavior/physiology

KW - Eating

KW - Emotions/physiology

KW - Energy Intake/physiology

KW - Fasting/physiology

KW - Female

KW - Food Preferences/physiology

KW - Humans

KW - Hydrocortisone/blood

KW - Image Processing, Computer-Assisted

KW - Linear Models

KW - Magnetic Resonance Imaging/methods

KW - Motivation/physiology

KW - Oxygen/blood

KW - Signal Transduction

KW - Young Adult

U2 - 10.1016/j.physbeh.2011.08.015

DO - 10.1016/j.physbeh.2011.08.015

M3 - Article

C2 - 21884714

VL - 105

SP - 321

EP - 324

JO - Physiology and Behavior

JF - Physiology and Behavior

SN - 0031-9384

IS - 2

ER -