Objective. To determine in critically-ill patients the relation between indicators of renal and hepatic dysfunction and plasma-ADMA concentration, and the association between ADMA concentration and survival. Design. Cross-sectional study. Method. Blood samples were prospectively collected from a cross-section of critically-ill patients (n = 52) with clinical evidence of dysfunction of two or more organs. Correlates were identified for plasma-ADMA concentration with laboratory values, organ-failure scores and outcome using univariate and multiple regression analyses. Results. In critically-ill patients, plasma-ADMA concentration was independently related to the presence of hepatic failure, and to lactic-acid and bilirubin concentration as markers of hepatic function. Twenty-one (40%) patients died during their ICU stay. In a logistic regression model, plasma ADMA ranked as the first and strongest predictor for outcome, with a 17-fold increased risk for ICU death in patients who were in the highest quartile for ADMA level. Conclusions. In critically-ill patients, plasma-ADMA concentration was a strong and independent risk factor for ICU mortality, and hepatic dysfunction was the most prominent determinant of ADMA concentration in this population.
|Translated title of the contribution||High plasma concentration of asymmetrical dimethylarginine (ADMA) as an independent predictor of mortality in intensive-care patients|
|Number of pages||6|
|Journal||Nederlands Tijdschrift voor Geneeskunde|
|Publication status||Published - 17 Apr 2004|