Hoge plasmaconcentratie van asymmetrisch dimethylarginine (ADMA) als onafhankelijke sterftevoorspeller bij intensivecarepatiënten

Translated title of the contribution: High plasma concentration of asymmetrical dimethylarginine (ADMA) as an independent predictor of mortality in intensive-care patients

R. J. Nijveldt, T. Teerlink, B. Van Der Hoven, M. P.C. Siroen, J. L. Bron, D. J. Kuik, J. A. Rauwerda, A. R.J. Girbes, P. A.M. Van Leeuwen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objective. To determine in critically-ill patients the relation between indicators of renal and hepatic dysfunction and plasma-ADMA concentration, and the association between ADMA concentration and survival. Design. Cross-sectional study. Method. Blood samples were prospectively collected from a cross-section of critically-ill patients (n = 52) with clinical evidence of dysfunction of two or more organs. Correlates were identified for plasma-ADMA concentration with laboratory values, organ-failure scores and outcome using univariate and multiple regression analyses. Results. In critically-ill patients, plasma-ADMA concentration was independently related to the presence of hepatic failure, and to lactic-acid and bilirubin concentration as markers of hepatic function. Twenty-one (40%) patients died during their ICU stay. In a logistic regression model, plasma ADMA ranked as the first and strongest predictor for outcome, with a 17-fold increased risk for ICU death in patients who were in the highest quartile for ADMA level. Conclusions. In critically-ill patients, plasma-ADMA concentration was a strong and independent risk factor for ICU mortality, and hepatic dysfunction was the most prominent determinant of ADMA concentration in this population.

Translated title of the contributionHigh plasma concentration of asymmetrical dimethylarginine (ADMA) as an independent predictor of mortality in intensive-care patients
Original languageDutch
Pages (from-to)782-787
Number of pages6
JournalNederlands Tijdschrift voor Geneeskunde
Volume148
Issue number16
Publication statusPublished - 17 Apr 2004

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