Hippocampal atrophy in Alzheimer disease: Age matters

L. A. Van De Pol*, A. Hensel, F. Barkhof, H. J. Gertz, P. Scheltens, W. M. Van Der Flier

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Hippocampal atrophy is a marker of Alzheimer disease (AD). It remains unclear whether this holds true for younger patients as well. Hippocampal volume was measured on MRI scans of 103 clinically diagnosed AD patients and 73 controls (aged 51 to 85 years). Aging and AD were independently associated with smaller hippocampal volume. Both young and old AD patients have hippocampal atrophy abnormal for age. Age-dependent criteria for hippocampal atrophy, suggestive of AD, are needed.

Original languageEnglish
Pages (from-to)236-238
Number of pages3
JournalNeurology
Volume66
Issue number2
DOIs
Publication statusPublished - 1 Jan 2006

Cite this