Histology of the bone marrow antibody response - An immunocytochemical study during the secondary response in mouse and rat

A. A. Geldof*, G. F. Rimmelzwaan, H. L. Langevoort

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


The histology of the specific and non-specific antibody response in mouse and rat bone marrow was studied after subcutaneous priming and intravenous boosting with horseradish peroxidase (HRP). Cells producing specific antibody against HRP were found only occasionally in the bone marrow after subcutaneous priming. After the intravenous boost injection their number gradually increased. These anti-HRP forming cells were found as single cells, randomly dispersed throughout the bone marrow. Such a random distribution was also found for cytoplasmic (non-specific) immunoglobulin containing cells. At no time point after immunization could lymphoid aggregates or trapping of immune complexes be observed in the bone marrow of either species. On the basis of these observations it is concluded that the bone marrow forms a suitable microenvironment for immigrating antibody-forming cells but does not contribute actively to the induction of the immune response.

Original languageEnglish
Pages (from-to)65-72
Number of pages8
JournalVirchows Archiv B Cell Pathology Including Molecular Pathology
Issue number1
Publication statusPublished - 1 Jan 1983

Cite this