HLA class II expression on tumor cells and low numbers of tumor-associated macrophages predict clinical outcome in oropharyngeal cancer

Bianca Cioni, Ekaterina S. Jordanova, Erik Hooijberg, Rianne van der Linden, Renee X. de Menezes, Katherine Tan, Stefan Willems, Joris B. W. Elbers, Annegien Broeks, Andries M. Bergman, Charlotte L. Zuur, Jan Paul de Boer

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is a highly immunogenic tumor and differences in tumor microenvironment might contribute to the improved survival of HPV-positive OPSCC patient. Methods: A comprehensive multivariate analysis with clinical and immune variables (human leukocyte antigen [HLA] I/II, programmed death ligand 1 (PD-L1), programmed death receptor 1 (PD1), T cells, and macrophages) was performed in 142 OPSCC patients. Results: We found an inverse correlation between the expression of HLA class II molecules on tumor cells and CD68+ CD163+ tumor-associated macrophages (TAMs). High HLA-DP/DQ/DR expression and low number of TAMs were associated with longer disease-specific survival and disease-free survival (DFS). Furthermore, a new population of CD8+ FoxP3+ T cells was correlated with shorter DFS in multivariate analysis. Conclusions: \We identified new prognostic markers for patients with oropharyngeal cancer, which can be used for selecting patients that can benefit from immunotherapy.
Original languageEnglish
Pages (from-to)463-478
Number of pages16
JournalHead and Neck
Volume41
Issue number2
Early online date2018
DOIs
Publication statusPublished - 1 Feb 2019

Cite this

Cioni, Bianca ; Jordanova, Ekaterina S. ; Hooijberg, Erik ; van der Linden, Rianne ; de Menezes, Renee X. ; Tan, Katherine ; Willems, Stefan ; Elbers, Joris B. W. ; Broeks, Annegien ; Bergman, Andries M. ; Zuur, Charlotte L. ; de Boer, Jan Paul. / HLA class II expression on tumor cells and low numbers of tumor-associated macrophages predict clinical outcome in oropharyngeal cancer. In: Head and Neck. 2019 ; Vol. 41, No. 2. pp. 463-478.
@article{94cd55f370ff41c686bc61eb9dfe56a4,
title = "HLA class II expression on tumor cells and low numbers of tumor-associated macrophages predict clinical outcome in oropharyngeal cancer",
abstract = "Background: Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is a highly immunogenic tumor and differences in tumor microenvironment might contribute to the improved survival of HPV-positive OPSCC patient. Methods: A comprehensive multivariate analysis with clinical and immune variables (human leukocyte antigen [HLA] I/II, programmed death ligand 1 (PD-L1), programmed death receptor 1 (PD1), T cells, and macrophages) was performed in 142 OPSCC patients. Results: We found an inverse correlation between the expression of HLA class II molecules on tumor cells and CD68+ CD163+ tumor-associated macrophages (TAMs). High HLA-DP/DQ/DR expression and low number of TAMs were associated with longer disease-specific survival and disease-free survival (DFS). Furthermore, a new population of CD8+ FoxP3+ T cells was correlated with shorter DFS in multivariate analysis. Conclusions: \We identified new prognostic markers for patients with oropharyngeal cancer, which can be used for selecting patients that can benefit from immunotherapy.",
author = "Bianca Cioni and Jordanova, {Ekaterina S.} and Erik Hooijberg and {van der Linden}, Rianne and {de Menezes}, {Renee X.} and Katherine Tan and Stefan Willems and Elbers, {Joris B. W.} and Annegien Broeks and Bergman, {Andries M.} and Zuur, {Charlotte L.} and {de Boer}, {Jan Paul}",
year = "2019",
month = "2",
day = "1",
doi = "10.1002/hed.25442",
language = "English",
volume = "41",
pages = "463--478",
journal = "Head and Neck",
issn = "1043-3074",
publisher = "Wiley Subscription Services, Inc., A Wiley Company Hoboken",
number = "2",

}

HLA class II expression on tumor cells and low numbers of tumor-associated macrophages predict clinical outcome in oropharyngeal cancer. / Cioni, Bianca; Jordanova, Ekaterina S.; Hooijberg, Erik; van der Linden, Rianne; de Menezes, Renee X.; Tan, Katherine; Willems, Stefan; Elbers, Joris B. W.; Broeks, Annegien; Bergman, Andries M.; Zuur, Charlotte L.; de Boer, Jan Paul.

In: Head and Neck, Vol. 41, No. 2, 01.02.2019, p. 463-478.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - HLA class II expression on tumor cells and low numbers of tumor-associated macrophages predict clinical outcome in oropharyngeal cancer

AU - Cioni, Bianca

AU - Jordanova, Ekaterina S.

AU - Hooijberg, Erik

AU - van der Linden, Rianne

AU - de Menezes, Renee X.

AU - Tan, Katherine

AU - Willems, Stefan

AU - Elbers, Joris B. W.

AU - Broeks, Annegien

AU - Bergman, Andries M.

AU - Zuur, Charlotte L.

AU - de Boer, Jan Paul

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Background: Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is a highly immunogenic tumor and differences in tumor microenvironment might contribute to the improved survival of HPV-positive OPSCC patient. Methods: A comprehensive multivariate analysis with clinical and immune variables (human leukocyte antigen [HLA] I/II, programmed death ligand 1 (PD-L1), programmed death receptor 1 (PD1), T cells, and macrophages) was performed in 142 OPSCC patients. Results: We found an inverse correlation between the expression of HLA class II molecules on tumor cells and CD68+ CD163+ tumor-associated macrophages (TAMs). High HLA-DP/DQ/DR expression and low number of TAMs were associated with longer disease-specific survival and disease-free survival (DFS). Furthermore, a new population of CD8+ FoxP3+ T cells was correlated with shorter DFS in multivariate analysis. Conclusions: \We identified new prognostic markers for patients with oropharyngeal cancer, which can be used for selecting patients that can benefit from immunotherapy.

AB - Background: Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is a highly immunogenic tumor and differences in tumor microenvironment might contribute to the improved survival of HPV-positive OPSCC patient. Methods: A comprehensive multivariate analysis with clinical and immune variables (human leukocyte antigen [HLA] I/II, programmed death ligand 1 (PD-L1), programmed death receptor 1 (PD1), T cells, and macrophages) was performed in 142 OPSCC patients. Results: We found an inverse correlation between the expression of HLA class II molecules on tumor cells and CD68+ CD163+ tumor-associated macrophages (TAMs). High HLA-DP/DQ/DR expression and low number of TAMs were associated with longer disease-specific survival and disease-free survival (DFS). Furthermore, a new population of CD8+ FoxP3+ T cells was correlated with shorter DFS in multivariate analysis. Conclusions: \We identified new prognostic markers for patients with oropharyngeal cancer, which can be used for selecting patients that can benefit from immunotherapy.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85058477744&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/30549362

U2 - 10.1002/hed.25442

DO - 10.1002/hed.25442

M3 - Article

VL - 41

SP - 463

EP - 478

JO - Head and Neck

JF - Head and Neck

SN - 1043-3074

IS - 2

ER -