HLA-DQB1*0304-DRB1*0408 haplotype associated with insulin-dependent diabetes mellitus in populations in the eastern Baltic region

J Ilonen, S Koskinen, S Nejentsev, M Sjöroos, M Knip, E I Schwartz, B Adojaan, L Kovalchuk, A Sochnevs

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The rare HLA-DQB1*0304 allele was found increased among IDDM patients in the populations of the eastern Baltic region. Its frequency among IDDM patients was 4.5% (20/443) compared to 1.1% (9/853) in healthy controls in the combined series of Estonian, Latvian and St. Petersburg Russian populations (P=0.0001). HLA-DQB1*0304 in these populations was associated with DRB1*0408, and the haplotype was further characterized by a B35 allele and a typical combination of microsatellite markers from the TNF gene region. The result is compatible with the significance of the 57th amino acid in the DQ beta-chain but also emphasizes the importance of alleles in other HLA loci adjacent to DQ in the determination of IDDM susceptibility.

LanguageEnglish
Pages532-4
Number of pages3
JournalTissue Antigens
Volume49
Issue number5
Publication statusPublished - May 1997

Cite this

Ilonen, J., Koskinen, S., Nejentsev, S., Sjöroos, M., Knip, M., Schwartz, E. I., ... Sochnevs, A. (1997). HLA-DQB1*0304-DRB1*0408 haplotype associated with insulin-dependent diabetes mellitus in populations in the eastern Baltic region. Tissue Antigens, 49(5), 532-4.
Ilonen, J ; Koskinen, S ; Nejentsev, S ; Sjöroos, M ; Knip, M ; Schwartz, E I ; Adojaan, B ; Kovalchuk, L ; Sochnevs, A. / HLA-DQB1*0304-DRB1*0408 haplotype associated with insulin-dependent diabetes mellitus in populations in the eastern Baltic region. In: Tissue Antigens. 1997 ; Vol. 49, No. 5. pp. 532-4.
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title = "HLA-DQB1*0304-DRB1*0408 haplotype associated with insulin-dependent diabetes mellitus in populations in the eastern Baltic region",
abstract = "The rare HLA-DQB1*0304 allele was found increased among IDDM patients in the populations of the eastern Baltic region. Its frequency among IDDM patients was 4.5{\%} (20/443) compared to 1.1{\%} (9/853) in healthy controls in the combined series of Estonian, Latvian and St. Petersburg Russian populations (P=0.0001). HLA-DQB1*0304 in these populations was associated with DRB1*0408, and the haplotype was further characterized by a B35 allele and a typical combination of microsatellite markers from the TNF gene region. The result is compatible with the significance of the 57th amino acid in the DQ beta-chain but also emphasizes the importance of alleles in other HLA loci adjacent to DQ in the determination of IDDM susceptibility.",
keywords = "Baltic States, Diabetes Mellitus, Type 1/epidemiology, Gene Frequency, HLA-DQ Antigens/genetics, HLA-DQ beta-Chains, Haplotypes, Humans",
author = "J Ilonen and S Koskinen and S Nejentsev and M Sj{\"o}roos and M Knip and Schwartz, {E I} and B Adojaan and L Kovalchuk and A Sochnevs",
year = "1997",
month = "5",
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Ilonen, J, Koskinen, S, Nejentsev, S, Sjöroos, M, Knip, M, Schwartz, EI, Adojaan, B, Kovalchuk, L & Sochnevs, A 1997, 'HLA-DQB1*0304-DRB1*0408 haplotype associated with insulin-dependent diabetes mellitus in populations in the eastern Baltic region', Tissue Antigens, vol. 49, no. 5, pp. 532-4.

HLA-DQB1*0304-DRB1*0408 haplotype associated with insulin-dependent diabetes mellitus in populations in the eastern Baltic region. / Ilonen, J; Koskinen, S; Nejentsev, S; Sjöroos, M; Knip, M; Schwartz, E I; Adojaan, B; Kovalchuk, L; Sochnevs, A.

In: Tissue Antigens, Vol. 49, No. 5, 05.1997, p. 532-4.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - HLA-DQB1*0304-DRB1*0408 haplotype associated with insulin-dependent diabetes mellitus in populations in the eastern Baltic region

AU - Ilonen, J

AU - Koskinen, S

AU - Nejentsev, S

AU - Sjöroos, M

AU - Knip, M

AU - Schwartz, E I

AU - Adojaan, B

AU - Kovalchuk, L

AU - Sochnevs, A

PY - 1997/5

Y1 - 1997/5

N2 - The rare HLA-DQB1*0304 allele was found increased among IDDM patients in the populations of the eastern Baltic region. Its frequency among IDDM patients was 4.5% (20/443) compared to 1.1% (9/853) in healthy controls in the combined series of Estonian, Latvian and St. Petersburg Russian populations (P=0.0001). HLA-DQB1*0304 in these populations was associated with DRB1*0408, and the haplotype was further characterized by a B35 allele and a typical combination of microsatellite markers from the TNF gene region. The result is compatible with the significance of the 57th amino acid in the DQ beta-chain but also emphasizes the importance of alleles in other HLA loci adjacent to DQ in the determination of IDDM susceptibility.

AB - The rare HLA-DQB1*0304 allele was found increased among IDDM patients in the populations of the eastern Baltic region. Its frequency among IDDM patients was 4.5% (20/443) compared to 1.1% (9/853) in healthy controls in the combined series of Estonian, Latvian and St. Petersburg Russian populations (P=0.0001). HLA-DQB1*0304 in these populations was associated with DRB1*0408, and the haplotype was further characterized by a B35 allele and a typical combination of microsatellite markers from the TNF gene region. The result is compatible with the significance of the 57th amino acid in the DQ beta-chain but also emphasizes the importance of alleles in other HLA loci adjacent to DQ in the determination of IDDM susceptibility.

KW - Baltic States

KW - Diabetes Mellitus, Type 1/epidemiology

KW - Gene Frequency

KW - HLA-DQ Antigens/genetics

KW - HLA-DQ beta-Chains

KW - Haplotypes

KW - Humans

M3 - Article

VL - 49

SP - 532

EP - 534

JO - Tissue Antigens

T2 - Tissue Antigens

JF - Tissue Antigens

SN - 0001-2815

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ER -