HLA-DQB1*0304-DRB1*0408 haplotype associated with insulin-dependent diabetes mellitus in populations in the eastern Baltic region

J Ilonen, S Koskinen, S Nejentsev, M Sjöroos, M Knip, E I Schwartz, B Adojaan, L Kovalchuk, A Sochnevs

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Abstract

The rare HLA-DQB1*0304 allele was found increased among IDDM patients in the populations of the eastern Baltic region. Its frequency among IDDM patients was 4.5% (20/443) compared to 1.1% (9/853) in healthy controls in the combined series of Estonian, Latvian and St. Petersburg Russian populations (P=0.0001). HLA-DQB1*0304 in these populations was associated with DRB1*0408, and the haplotype was further characterized by a B35 allele and a typical combination of microsatellite markers from the TNF gene region. The result is compatible with the significance of the 57th amino acid in the DQ beta-chain but also emphasizes the importance of alleles in other HLA loci adjacent to DQ in the determination of IDDM susceptibility.

Original languageEnglish
Pages (from-to)532-4
Number of pages3
JournalTissue Antigens
Volume49
Issue number5
Publication statusPublished - May 1997

Cite this

Ilonen, J., Koskinen, S., Nejentsev, S., Sjöroos, M., Knip, M., Schwartz, E. I., ... Sochnevs, A. (1997). HLA-DQB1*0304-DRB1*0408 haplotype associated with insulin-dependent diabetes mellitus in populations in the eastern Baltic region. Tissue Antigens, 49(5), 532-4.