HLA-DR4 subtype and -B alleles in DQB1*0302-positive haplotypes associated with IDDM. The Childhood Diabetes in Finland Study Group

H Reijonen, S Nejentsev, J Tuokko, S Koskinen, E Tuomilehto-Wolf, H K Akerblom, J Ilonen

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

We determined the distribution of DR4 subtypes in 309 DQB1*0302-positive haplotypes found in insulin-dependent diabetes mellitus (IDDM) patients and 70 control haplotypes present only in healthy family members. An increased frequency of DRB1*0401 allele (74.4% vs. 55.7%, P = 0.003) and a decrease of DRB1*0404 allele (23.6% vs. 40.0%, P = 0.0064) was revealed. A further analysis of extended haplotypes demonstrated strong linkages between various B alleles and DRB1*04 subtypes. HLA-B39 was more frequent in DRB1*0404-DQB1*0302-positive IDDM haplotypes compared with control ones (37.0% vs. 14.3%, P = 0.049), suggesting an involvement of the region telomeric to HLA-DRB1 in the susceptibility to IDDM.

LanguageEnglish
Pages357-63
Number of pages7
JournalEuropean journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics
Volume24
Issue number5
Publication statusPublished - Oct 1997

Cite this

@article{e9b27cfed08641759884f5ea34a5de98,
title = "HLA-DR4 subtype and -B alleles in DQB1*0302-positive haplotypes associated with IDDM. The Childhood Diabetes in Finland Study Group",
abstract = "We determined the distribution of DR4 subtypes in 309 DQB1*0302-positive haplotypes found in insulin-dependent diabetes mellitus (IDDM) patients and 70 control haplotypes present only in healthy family members. An increased frequency of DRB1*0401 allele (74.4{\%} vs. 55.7{\%}, P = 0.003) and a decrease of DRB1*0404 allele (23.6{\%} vs. 40.0{\%}, P = 0.0064) was revealed. A further analysis of extended haplotypes demonstrated strong linkages between various B alleles and DRB1*04 subtypes. HLA-B39 was more frequent in DRB1*0404-DQB1*0302-positive IDDM haplotypes compared with control ones (37.0{\%} vs. 14.3{\%}, P = 0.049), suggesting an involvement of the region telomeric to HLA-DRB1 in the susceptibility to IDDM.",
keywords = "Adolescent, Alleles, Child, Child, Preschool, Diabetes Mellitus, Type 1/epidemiology, Disease Susceptibility, Finland/epidemiology, Gene Frequency, Genetic Linkage, HLA-B Antigens/analysis, HLA-DQ Antigens/genetics, HLA-DQ beta-Chains, HLA-DR Antigens/analysis, HLA-DR4 Antigen/analysis, HLA-DRB1 Chains, Haplotypes/genetics, Humans, Risk Factors",
author = "H Reijonen and S Nejentsev and J Tuokko and S Koskinen and E Tuomilehto-Wolf and Akerblom, {H K} and J Ilonen",
year = "1997",
month = "10",
language = "English",
volume = "24",
pages = "357--63",
journal = "European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics",
issn = "0960-7420",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "5",

}

HLA-DR4 subtype and -B alleles in DQB1*0302-positive haplotypes associated with IDDM. The Childhood Diabetes in Finland Study Group. / Reijonen, H; Nejentsev, S; Tuokko, J; Koskinen, S; Tuomilehto-Wolf, E; Akerblom, H K; Ilonen, J.

In: European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics, Vol. 24, No. 5, 10.1997, p. 357-63.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - HLA-DR4 subtype and -B alleles in DQB1*0302-positive haplotypes associated with IDDM. The Childhood Diabetes in Finland Study Group

AU - Reijonen, H

AU - Nejentsev, S

AU - Tuokko, J

AU - Koskinen, S

AU - Tuomilehto-Wolf, E

AU - Akerblom, H K

AU - Ilonen, J

PY - 1997/10

Y1 - 1997/10

N2 - We determined the distribution of DR4 subtypes in 309 DQB1*0302-positive haplotypes found in insulin-dependent diabetes mellitus (IDDM) patients and 70 control haplotypes present only in healthy family members. An increased frequency of DRB1*0401 allele (74.4% vs. 55.7%, P = 0.003) and a decrease of DRB1*0404 allele (23.6% vs. 40.0%, P = 0.0064) was revealed. A further analysis of extended haplotypes demonstrated strong linkages between various B alleles and DRB1*04 subtypes. HLA-B39 was more frequent in DRB1*0404-DQB1*0302-positive IDDM haplotypes compared with control ones (37.0% vs. 14.3%, P = 0.049), suggesting an involvement of the region telomeric to HLA-DRB1 in the susceptibility to IDDM.

AB - We determined the distribution of DR4 subtypes in 309 DQB1*0302-positive haplotypes found in insulin-dependent diabetes mellitus (IDDM) patients and 70 control haplotypes present only in healthy family members. An increased frequency of DRB1*0401 allele (74.4% vs. 55.7%, P = 0.003) and a decrease of DRB1*0404 allele (23.6% vs. 40.0%, P = 0.0064) was revealed. A further analysis of extended haplotypes demonstrated strong linkages between various B alleles and DRB1*04 subtypes. HLA-B39 was more frequent in DRB1*0404-DQB1*0302-positive IDDM haplotypes compared with control ones (37.0% vs. 14.3%, P = 0.049), suggesting an involvement of the region telomeric to HLA-DRB1 in the susceptibility to IDDM.

KW - Adolescent

KW - Alleles

KW - Child

KW - Child, Preschool

KW - Diabetes Mellitus, Type 1/epidemiology

KW - Disease Susceptibility

KW - Finland/epidemiology

KW - Gene Frequency

KW - Genetic Linkage

KW - HLA-B Antigens/analysis

KW - HLA-DQ Antigens/genetics

KW - HLA-DQ beta-Chains

KW - HLA-DR Antigens/analysis

KW - HLA-DR4 Antigen/analysis

KW - HLA-DRB1 Chains

KW - Haplotypes/genetics

KW - Humans

KW - Risk Factors

M3 - Article

VL - 24

SP - 357

EP - 363

JO - European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics

T2 - European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics

JF - European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics

SN - 0960-7420

IS - 5

ER -