HLA-DR4 subtype and -B alleles in DQB1*0302-positive haplotypes associated with IDDM. The Childhood Diabetes in Finland Study Group

H Reijonen, S Nejentsev, J Tuokko, S Koskinen, E Tuomilehto-Wolf, H K Akerblom, J Ilonen

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

We determined the distribution of DR4 subtypes in 309 DQB1*0302-positive haplotypes found in insulin-dependent diabetes mellitus (IDDM) patients and 70 control haplotypes present only in healthy family members. An increased frequency of DRB1*0401 allele (74.4% vs. 55.7%, P = 0.003) and a decrease of DRB1*0404 allele (23.6% vs. 40.0%, P = 0.0064) was revealed. A further analysis of extended haplotypes demonstrated strong linkages between various B alleles and DRB1*04 subtypes. HLA-B39 was more frequent in DRB1*0404-DQB1*0302-positive IDDM haplotypes compared with control ones (37.0% vs. 14.3%, P = 0.049), suggesting an involvement of the region telomeric to HLA-DRB1 in the susceptibility to IDDM.

Original languageEnglish
Pages (from-to)357-63
Number of pages7
JournalEuropean journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics
Volume24
Issue number5
Publication statusPublished - Oct 1997

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