How LFA-1 binds to different ligands

M E Binnerts, Y van Kooyk

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The integrin leukocyte function-associated antigen 1 (LFA-1) is pivotal for cell adhesion and signalling within the immune system. Here, Minke Binnerts and Yvette van Kooyk discuss evidence from mutational and crystallographic studies showing that binding of LFA-1 to its ligands intercellular adhesion molecule 1 (ICAM-1), -2 and -3 might be structurally distinct.

Original languageEnglish
Pages (from-to)240-5
Number of pages6
JournalImmunology today
Volume20
Issue number5
Publication statusPublished - May 1999

Cite this

Binnerts, M E ; van Kooyk, Y. / How LFA-1 binds to different ligands. In: Immunology today. 1999 ; Vol. 20, No. 5. pp. 240-5.
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Binnerts, ME & van Kooyk, Y 1999, 'How LFA-1 binds to different ligands' Immunology today, vol. 20, no. 5, pp. 240-5.

How LFA-1 binds to different ligands. / Binnerts, M E; van Kooyk, Y.

In: Immunology today, Vol. 20, No. 5, 05.1999, p. 240-5.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - How LFA-1 binds to different ligands

AU - Binnerts, M E

AU - van Kooyk, Y

PY - 1999/5

Y1 - 1999/5

N2 - The integrin leukocyte function-associated antigen 1 (LFA-1) is pivotal for cell adhesion and signalling within the immune system. Here, Minke Binnerts and Yvette van Kooyk discuss evidence from mutational and crystallographic studies showing that binding of LFA-1 to its ligands intercellular adhesion molecule 1 (ICAM-1), -2 and -3 might be structurally distinct.

AB - The integrin leukocyte function-associated antigen 1 (LFA-1) is pivotal for cell adhesion and signalling within the immune system. Here, Minke Binnerts and Yvette van Kooyk discuss evidence from mutational and crystallographic studies showing that binding of LFA-1 to its ligands intercellular adhesion molecule 1 (ICAM-1), -2 and -3 might be structurally distinct.

KW - Animals

KW - Binding Sites

KW - Cell Adhesion Molecules/metabolism

KW - Humans

KW - Ligands

KW - Lymphocyte Function-Associated Antigen-1/chemistry

KW - Models, Molecular

KW - Protein Conformation

M3 - Article

VL - 20

SP - 240

EP - 245

JO - Immunology today

JF - Immunology today

SN - 0167-5699

IS - 5

ER -