How neutrophils kill fungi

Roel P Gazendam, Annemarie van de Geer, Dirk Roos, Timo K van den Berg, Taco W. Kuijpers

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Neutrophils play a critical role in the prevention of invasive fungal infections. Whereas mouse studies have demonstrated the role of various neutrophil pathogen recognition receptors (PRRs), signal transduction pathways, and cytotoxicity in the murine antifungal immune response, much less is known about the killing of fungi by human neutrophils. Recently, novel primary immunodeficiencies have been identified in patients with a susceptibility to fungal infections. These human 'knock-out' neutrophils expand our knowledge to understand the role of PRRs and signaling in human fungal killing. From the studies with these patients it is becoming clear that neutrophils employ fundamentally distinct mechanisms to kill Candida albicans or Aspergillus fumigatus.

Original languageEnglish
Pages (from-to)299-311
Number of pages13
JournalImmunological Reviews
Volume273
Issue number1
DOIs
Publication statusPublished - Sep 2016

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