HPV infections and flat penile lesions of the penis in men who have sex with men

Ward P. H. van Bilsen, Alexandra Kovaleva, Maaike C. G. Bleeker, Audrey J. King, Sylvia M. Bruisten, Wilma Brokking, Henry J. C. de Vries, Chris J. L. M. Meijer, Maarten F. Schim van der Loeff

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: Flat penile lesions (FPL) in heterosexual men are thought to play a role in the transmission of HPV. We investigated the association between FPL and penile HPV, and explored determinants of FPL in men who have sex with men (MSM). Methods: In 2015–2016, MSM were recruited based on HIV and penile HPV status in a previous cohort. MSM self-completed a questionnaire. Peniscopy was performed after application of acetic acid to visualize FPL. Penile physician-collected samples were tested for HPV-DNA using the highly sensitive SPF10-PCR DEIA/LiPA25 system. HPV viral load (VL) was determined using a quantitative type-specific (q)PCR targeting the L1-region. Presence of HPV and HIV, HPV VL and circumcision status were compared between MSM with and without FPL. Results: We included 116 MSM, of whom 59/116 (51%) MSM were HIV-positive and 54/116 (47%) had FPL. A penile HPV infection was present in 31/54 (57%) MSM with FPL and 34/62 (55%) MSM without FPL (p = 0.8). There was no difference between MSM with and without FPL regarding presence of penile HPV infection, HPV VL, HIV status or circumcision status (p > 0.05 for all). Conclusion: Among MSM in Amsterdam, we found no association between FPL and penile HPV, HPV VL, HIV status or circumcision status.
Original languageEnglish
Article number100173
JournalPAPILLOMAVIRUS RESEARCH
Volume8
DOIs
Publication statusPublished - 2019

Cite this

van Bilsen, W. P. H., Kovaleva, A., Bleeker, M. C. G., King, A. J., Bruisten, S. M., Brokking, W., ... Schim van der Loeff, M. F. (2019). HPV infections and flat penile lesions of the penis in men who have sex with men. PAPILLOMAVIRUS RESEARCH, 8, [100173]. https://doi.org/10.1016/j.pvr.2019.100173
van Bilsen, Ward P. H. ; Kovaleva, Alexandra ; Bleeker, Maaike C. G. ; King, Audrey J. ; Bruisten, Sylvia M. ; Brokking, Wilma ; de Vries, Henry J. C. ; Meijer, Chris J. L. M. ; Schim van der Loeff, Maarten F. / HPV infections and flat penile lesions of the penis in men who have sex with men. In: PAPILLOMAVIRUS RESEARCH. 2019 ; Vol. 8.
@article{c42a6ea52d444bacabab58041b6f2afa,
title = "HPV infections and flat penile lesions of the penis in men who have sex with men",
abstract = "Background: Flat penile lesions (FPL) in heterosexual men are thought to play a role in the transmission of HPV. We investigated the association between FPL and penile HPV, and explored determinants of FPL in men who have sex with men (MSM). Methods: In 2015–2016, MSM were recruited based on HIV and penile HPV status in a previous cohort. MSM self-completed a questionnaire. Peniscopy was performed after application of acetic acid to visualize FPL. Penile physician-collected samples were tested for HPV-DNA using the highly sensitive SPF10-PCR DEIA/LiPA25 system. HPV viral load (VL) was determined using a quantitative type-specific (q)PCR targeting the L1-region. Presence of HPV and HIV, HPV VL and circumcision status were compared between MSM with and without FPL. Results: We included 116 MSM, of whom 59/116 (51{\%}) MSM were HIV-positive and 54/116 (47{\%}) had FPL. A penile HPV infection was present in 31/54 (57{\%}) MSM with FPL and 34/62 (55{\%}) MSM without FPL (p = 0.8). There was no difference between MSM with and without FPL regarding presence of penile HPV infection, HPV VL, HIV status or circumcision status (p > 0.05 for all). Conclusion: Among MSM in Amsterdam, we found no association between FPL and penile HPV, HPV VL, HIV status or circumcision status.",
author = "{van Bilsen}, {Ward P. H.} and Alexandra Kovaleva and Bleeker, {Maaike C. G.} and King, {Audrey J.} and Bruisten, {Sylvia M.} and Wilma Brokking and {de Vries}, {Henry J. C.} and Meijer, {Chris J. L. M.} and {Schim van der Loeff}, {Maarten F.}",
year = "2019",
doi = "10.1016/j.pvr.2019.100173",
language = "English",
volume = "8",
journal = "PAPILLOMAVIRUS RESEARCH",
issn = "2405-8521",
publisher = "Elsevier BV",

}

HPV infections and flat penile lesions of the penis in men who have sex with men. / van Bilsen, Ward P. H.; Kovaleva, Alexandra; Bleeker, Maaike C. G.; King, Audrey J.; Bruisten, Sylvia M.; Brokking, Wilma; de Vries, Henry J. C.; Meijer, Chris J. L. M.; Schim van der Loeff, Maarten F.

In: PAPILLOMAVIRUS RESEARCH, Vol. 8, 100173, 2019.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - HPV infections and flat penile lesions of the penis in men who have sex with men

AU - van Bilsen, Ward P. H.

AU - Kovaleva, Alexandra

AU - Bleeker, Maaike C. G.

AU - King, Audrey J.

AU - Bruisten, Sylvia M.

AU - Brokking, Wilma

AU - de Vries, Henry J. C.

AU - Meijer, Chris J. L. M.

AU - Schim van der Loeff, Maarten F.

PY - 2019

Y1 - 2019

N2 - Background: Flat penile lesions (FPL) in heterosexual men are thought to play a role in the transmission of HPV. We investigated the association between FPL and penile HPV, and explored determinants of FPL in men who have sex with men (MSM). Methods: In 2015–2016, MSM were recruited based on HIV and penile HPV status in a previous cohort. MSM self-completed a questionnaire. Peniscopy was performed after application of acetic acid to visualize FPL. Penile physician-collected samples were tested for HPV-DNA using the highly sensitive SPF10-PCR DEIA/LiPA25 system. HPV viral load (VL) was determined using a quantitative type-specific (q)PCR targeting the L1-region. Presence of HPV and HIV, HPV VL and circumcision status were compared between MSM with and without FPL. Results: We included 116 MSM, of whom 59/116 (51%) MSM were HIV-positive and 54/116 (47%) had FPL. A penile HPV infection was present in 31/54 (57%) MSM with FPL and 34/62 (55%) MSM without FPL (p = 0.8). There was no difference between MSM with and without FPL regarding presence of penile HPV infection, HPV VL, HIV status or circumcision status (p > 0.05 for all). Conclusion: Among MSM in Amsterdam, we found no association between FPL and penile HPV, HPV VL, HIV status or circumcision status.

AB - Background: Flat penile lesions (FPL) in heterosexual men are thought to play a role in the transmission of HPV. We investigated the association between FPL and penile HPV, and explored determinants of FPL in men who have sex with men (MSM). Methods: In 2015–2016, MSM were recruited based on HIV and penile HPV status in a previous cohort. MSM self-completed a questionnaire. Peniscopy was performed after application of acetic acid to visualize FPL. Penile physician-collected samples were tested for HPV-DNA using the highly sensitive SPF10-PCR DEIA/LiPA25 system. HPV viral load (VL) was determined using a quantitative type-specific (q)PCR targeting the L1-region. Presence of HPV and HIV, HPV VL and circumcision status were compared between MSM with and without FPL. Results: We included 116 MSM, of whom 59/116 (51%) MSM were HIV-positive and 54/116 (47%) had FPL. A penile HPV infection was present in 31/54 (57%) MSM with FPL and 34/62 (55%) MSM without FPL (p = 0.8). There was no difference between MSM with and without FPL regarding presence of penile HPV infection, HPV VL, HIV status or circumcision status (p > 0.05 for all). Conclusion: Among MSM in Amsterdam, we found no association between FPL and penile HPV, HPV VL, HIV status or circumcision status.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85067693498&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/31226447

U2 - 10.1016/j.pvr.2019.100173

DO - 10.1016/j.pvr.2019.100173

M3 - Article

VL - 8

JO - PAPILLOMAVIRUS RESEARCH

JF - PAPILLOMAVIRUS RESEARCH

SN - 2405-8521

M1 - 100173

ER -