HPV type concordance in sexual couples determines the effect of condoms on regression of flat penile lesions

M C G Bleeker, J Berkhof, C J A Hogewoning, F J Voorhorst, A J C van den Brule, T M Starink, P J F Snijders, C J L M Meijer

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

We earlier demonstrated, in a randomised clinical trial, that the regression time of flat penile lesions in male sexual partners of women with cervical intraepithelial neoplasia (CIN) was shorter in men who used condoms compared to those who did not. To further evaluate this finding, we examined whether the effect of condom use on the regression of flat penile lesions depends on the presence of human papillomavirus (HPV) type concordance in sexual couples, as determined in cervical and penile scrapes by GP5+/6+ PCR testing. A Cox model with time-dependent covariates showed a beneficial effect of condoms on regression of flat penile lesions in concordant couples (hazard ratio 2.63, 95% CI 1.07-6.48) but not in those who were nonconcordant. When both partners harboured different HPV types, no effect of condoms was found (hazard ratio 0.90, 95% CI 0.27-2.96). Delayed regression of flat penile lesions was associated with either stable lesions or with new penile lesions developing at sites surrounding pre-existing lesions suggesting reinfection of the penile epithelium. We conclude that condom use blocks sexual HPV transmission by preventing reinfection and development of new penile lesions in men who are susceptible to the same type as present in the female partner.

Original languageEnglish
Pages (from-to)1388-1392
Number of pages5
JournalBritish Journal of Cancer
Volume92
Issue number8
DOIs
Publication statusPublished - 25 Apr 2005

Cite this

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title = "HPV type concordance in sexual couples determines the effect of condoms on regression of flat penile lesions",
abstract = "We earlier demonstrated, in a randomised clinical trial, that the regression time of flat penile lesions in male sexual partners of women with cervical intraepithelial neoplasia (CIN) was shorter in men who used condoms compared to those who did not. To further evaluate this finding, we examined whether the effect of condom use on the regression of flat penile lesions depends on the presence of human papillomavirus (HPV) type concordance in sexual couples, as determined in cervical and penile scrapes by GP5+/6+ PCR testing. A Cox model with time-dependent covariates showed a beneficial effect of condoms on regression of flat penile lesions in concordant couples (hazard ratio 2.63, 95{\%} CI 1.07-6.48) but not in those who were nonconcordant. When both partners harboured different HPV types, no effect of condoms was found (hazard ratio 0.90, 95{\%} CI 0.27-2.96). Delayed regression of flat penile lesions was associated with either stable lesions or with new penile lesions developing at sites surrounding pre-existing lesions suggesting reinfection of the penile epithelium. We conclude that condom use blocks sexual HPV transmission by preventing reinfection and development of new penile lesions in men who are susceptible to the same type as present in the female partner.",
keywords = "Adult, Animals, Cervical Intraepithelial Neoplasia, Condoms, Female, Humans, Male, Middle Aged, Papillomaviridae, Papillomavirus Infections, Penile Diseases, Polymerase Chain Reaction, Sexual Partners, Tumor Virus Infections, Uterine Cervical Neoplasms, Journal Article, Research Support, Non-U.S. Gov't",
author = "Bleeker, {M C G} and J Berkhof and Hogewoning, {C J A} and Voorhorst, {F J} and {van den Brule}, {A J C} and Starink, {T M} and Snijders, {P J F} and Meijer, {C J L M}",
year = "2005",
month = "4",
day = "25",
doi = "10.1038/sj.bjc.6602524",
language = "English",
volume = "92",
pages = "1388--1392",
journal = "British Journal of Cancer",
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HPV type concordance in sexual couples determines the effect of condoms on regression of flat penile lesions. / Bleeker, M C G; Berkhof, J; Hogewoning, C J A; Voorhorst, F J; van den Brule, A J C; Starink, T M; Snijders, P J F; Meijer, C J L M.

In: British Journal of Cancer, Vol. 92, No. 8, 25.04.2005, p. 1388-1392.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - HPV type concordance in sexual couples determines the effect of condoms on regression of flat penile lesions

AU - Bleeker, M C G

AU - Berkhof, J

AU - Hogewoning, C J A

AU - Voorhorst, F J

AU - van den Brule, A J C

AU - Starink, T M

AU - Snijders, P J F

AU - Meijer, C J L M

PY - 2005/4/25

Y1 - 2005/4/25

N2 - We earlier demonstrated, in a randomised clinical trial, that the regression time of flat penile lesions in male sexual partners of women with cervical intraepithelial neoplasia (CIN) was shorter in men who used condoms compared to those who did not. To further evaluate this finding, we examined whether the effect of condom use on the regression of flat penile lesions depends on the presence of human papillomavirus (HPV) type concordance in sexual couples, as determined in cervical and penile scrapes by GP5+/6+ PCR testing. A Cox model with time-dependent covariates showed a beneficial effect of condoms on regression of flat penile lesions in concordant couples (hazard ratio 2.63, 95% CI 1.07-6.48) but not in those who were nonconcordant. When both partners harboured different HPV types, no effect of condoms was found (hazard ratio 0.90, 95% CI 0.27-2.96). Delayed regression of flat penile lesions was associated with either stable lesions or with new penile lesions developing at sites surrounding pre-existing lesions suggesting reinfection of the penile epithelium. We conclude that condom use blocks sexual HPV transmission by preventing reinfection and development of new penile lesions in men who are susceptible to the same type as present in the female partner.

AB - We earlier demonstrated, in a randomised clinical trial, that the regression time of flat penile lesions in male sexual partners of women with cervical intraepithelial neoplasia (CIN) was shorter in men who used condoms compared to those who did not. To further evaluate this finding, we examined whether the effect of condom use on the regression of flat penile lesions depends on the presence of human papillomavirus (HPV) type concordance in sexual couples, as determined in cervical and penile scrapes by GP5+/6+ PCR testing. A Cox model with time-dependent covariates showed a beneficial effect of condoms on regression of flat penile lesions in concordant couples (hazard ratio 2.63, 95% CI 1.07-6.48) but not in those who were nonconcordant. When both partners harboured different HPV types, no effect of condoms was found (hazard ratio 0.90, 95% CI 0.27-2.96). Delayed regression of flat penile lesions was associated with either stable lesions or with new penile lesions developing at sites surrounding pre-existing lesions suggesting reinfection of the penile epithelium. We conclude that condom use blocks sexual HPV transmission by preventing reinfection and development of new penile lesions in men who are susceptible to the same type as present in the female partner.

KW - Adult

KW - Animals

KW - Cervical Intraepithelial Neoplasia

KW - Condoms

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Papillomaviridae

KW - Papillomavirus Infections

KW - Penile Diseases

KW - Polymerase Chain Reaction

KW - Sexual Partners

KW - Tumor Virus Infections

KW - Uterine Cervical Neoplasms

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1038/sj.bjc.6602524

DO - 10.1038/sj.bjc.6602524

M3 - Article

VL - 92

SP - 1388

EP - 1392

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

IS - 8

ER -