HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions

Elspeth A. Bruford; Cristina R. Antonescu; Andrew J. Carroll; Arul Chinnaiyan; Ian A. Cree; Nicholas C. P. Cross; Raymond Dalgleish; Robert Peter Gale; Christine J. Harrison; Rosalind J. Hastings; Jean-Loup Huret; Bertil Johansson; Michelle le Beau; Cristina Mecucci; Fredrik Mertens; Roel Verhaak; Felix Mitelman

doi:10.1038/s41375-021-01436-6

HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions

Elspeth A. Bruford^*, Cristina R. Antonescu, Andrew J. Carroll, Arul Chinnaiyan, Ian A. Cree, Nicholas C. P. Cross, Raymond Dalgleish, Robert Peter Gale, Christine J. Harrison, Rosalind J. Hastings, Jean-Loup Huret, Bertil Johansson, Michelle le Beau, Cristina Mecucci, Fredrik Mertens, Roel Verhaak, Felix Mitelman

^*Corresponding author for this work

Neurosurgery

Research output: Contribution to journal › Comment/Letter to the editor › Academic

Abstract

Gene fusions have been discussed in the scientific literature since they were first detected in cancer cells in the early 1980s. There is currently no standardized way to denote the genes involved in fusions, but in the majority of publications the gene symbols in question are listed either separated by a hyphen (-) or by a forward slash (/). Both types of designation suffer from important shortcomings. HGNC has worked with the scientific community to determine a new, instantly recognizable and unique separator—a double colon (::)—to be used in the description of fusion genes, and advocates its usage in all databases and articles describing gene fusions.

Original language	English
Pages (from-to)	3040-3043
Number of pages	4
Journal	Leukemia
Volume	35
Issue number	11
Early online date	2021
DOIs	https://doi.org/10.1038/s41375-021-01436-6
Publication status	Published - Nov 2021

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Bruford, E. A., Antonescu, C. R., Carroll, A. J., Chinnaiyan, A., Cree, I. A., Cross, N. C. P., Dalgleish, R., Gale, R. P., Harrison, C. J., Hastings, R. J., Huret, J-L., Johansson, B., le Beau, M., Mecucci, C., Mertens, F., Verhaak, R., & Mitelman, F. (2021). HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions. Leukemia, 35(11), 3040-3043. https://doi.org/10.1038/s41375-021-01436-6

@article{83206eaeb04f47a39393521bc2834526,

title = "HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions",

abstract = "Gene fusions have been discussed in the scientific literature since they were first detected in cancer cells in the early 1980s. There is currently no standardized way to denote the genes involved in fusions, but in the majority of publications the gene symbols in question are listed either separated by a hyphen (-) or by a forward slash (/). Both types of designation suffer from important shortcomings. HGNC has worked with the scientific community to determine a new, instantly recognizable and unique separator—a double colon (::)—to be used in the description of fusion genes, and advocates its usage in all databases and articles describing gene fusions.",

author = "Bruford, {Elspeth A.} and Antonescu, {Cristina R.} and Carroll, {Andrew J.} and Arul Chinnaiyan and Cree, {Ian A.} and Cross, {Nicholas C. P.} and Raymond Dalgleish and Gale, {Robert Peter} and Harrison, {Christine J.} and Hastings, {Rosalind J.} and Jean-Loup Huret and Bertil Johansson and {le Beau}, Michelle and Cristina Mecucci and Fredrik Mertens and Roel Verhaak and Felix Mitelman",

note = "Funding Information: MLB is a member of the Board of Directors of the American Cancer Society and a member of the ACS Cancer Action Network; RV is a co-founder of, and has received research funding from, Boundless Bio. Funding Information: EAB is currently funded by the National Human Genome Research Institute (NHGRI) grant U24HG003345 and Wellcome Trust grant 208349/Z/17/Z. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health, nor the views of the authors{\textquoteright} employers and associated institutions. Where authors are identified as personnel of the International Agency for Research on Cancer/World Health Organization, the authors alone are responsible for the views expressed in this article and they do not necessarily represent the decisions, policy, or views of the International Agency for Research on Cancer/World Health Organization. We thank our colleagues from the College of American Pathologists, and Dr Zbyslaw Sondka from COSMIC, for useful discussions. Publisher Copyright: {\textcopyright} 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

month = nov,

doi = "10.1038/s41375-021-01436-6",

language = "English",

volume = "35",

pages = "3040--3043",

journal = "Leukemia",

issn = "0887-6924",

publisher = "Nature Publishing Group",

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Bruford, EA, Antonescu, CR, Carroll, AJ, Chinnaiyan, A, Cree, IA, Cross, NCP, Dalgleish, R, Gale, RP, Harrison, CJ, Hastings, RJ, Huret, J-L, Johansson, B, le Beau, M, Mecucci, C, Mertens, F, Verhaak, R & Mitelman, F 2021, 'HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions', Leukemia, vol. 35, no. 11, pp. 3040-3043. https://doi.org/10.1038/s41375-021-01436-6

TY - JOUR

T1 - HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions

AU - Bruford, Elspeth A.

AU - Antonescu, Cristina R.

AU - Carroll, Andrew J.

AU - Chinnaiyan, Arul

AU - Cree, Ian A.

AU - Cross, Nicholas C. P.

AU - Dalgleish, Raymond

AU - Gale, Robert Peter

AU - Harrison, Christine J.

AU - Hastings, Rosalind J.

AU - Huret, Jean-Loup

AU - Johansson, Bertil

AU - le Beau, Michelle

AU - Mecucci, Cristina

AU - Mertens, Fredrik

AU - Verhaak, Roel

AU - Mitelman, Felix

N1 - Funding Information: MLB is a member of the Board of Directors of the American Cancer Society and a member of the ACS Cancer Action Network; RV is a co-founder of, and has received research funding from, Boundless Bio. Funding Information: EAB is currently funded by the National Human Genome Research Institute (NHGRI) grant U24HG003345 and Wellcome Trust grant 208349/Z/17/Z. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health, nor the views of the authors’ employers and associated institutions. Where authors are identified as personnel of the International Agency for Research on Cancer/World Health Organization, the authors alone are responsible for the views expressed in this article and they do not necessarily represent the decisions, policy, or views of the International Agency for Research on Cancer/World Health Organization. We thank our colleagues from the College of American Pathologists, and Dr Zbyslaw Sondka from COSMIC, for useful discussions. Publisher Copyright: © 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/11

Y1 - 2021/11

N2 - Gene fusions have been discussed in the scientific literature since they were first detected in cancer cells in the early 1980s. There is currently no standardized way to denote the genes involved in fusions, but in the majority of publications the gene symbols in question are listed either separated by a hyphen (-) or by a forward slash (/). Both types of designation suffer from important shortcomings. HGNC has worked with the scientific community to determine a new, instantly recognizable and unique separator—a double colon (::)—to be used in the description of fusion genes, and advocates its usage in all databases and articles describing gene fusions.

AB - Gene fusions have been discussed in the scientific literature since they were first detected in cancer cells in the early 1980s. There is currently no standardized way to denote the genes involved in fusions, but in the majority of publications the gene symbols in question are listed either separated by a hyphen (-) or by a forward slash (/). Both types of designation suffer from important shortcomings. HGNC has worked with the scientific community to determine a new, instantly recognizable and unique separator—a double colon (::)—to be used in the description of fusion genes, and advocates its usage in all databases and articles describing gene fusions.

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U2 - 10.1038/s41375-021-01436-6

DO - 10.1038/s41375-021-01436-6

M3 - Comment/Letter to the editor

C2 - 34615987

VL - 35

SP - 3040

EP - 3043

JO - Leukemia

JF - Leukemia

SN - 0887-6924

IS - 11

ER -

HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions

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