Human dosimetry of the n-methyl-d-aspartate receptor ligand 11C-GMOM

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The methylguaniDine derivative 11C-GMOM (11C-labeled N-(2-chloro-3-thiomethylphenyl)-N9-(3-methoxyphenyl)-N9-methylguaniDine) has been used successfully to quantify N-methyl-D-aspartate (NMDA) receptor binDing in humans. The purpose of the present study was to estimate the 11C-GMOM raDiation dose in healthy humans. Methods: After 11C-GMOM injection, 3 female and 2 male subjects underwent 10 consecutive whole-body PET scans in approximately 77 min. Seven source organs were defined manually, scaled to a sex-specific reference, and residence times were calculated for input into OLINDA/EXM software. Accepted tissue-weighting factors were used to calculate the effective dose. Results: The mean absorbed raDiation doses in source organs ranged from 7.7 mGy-MBq21 in the brain to 12.7 mGy-MBq21 in the spleen. The effective dose (6SD) was 4.5 6 0.5 mSv-MBq21. Conclusion: The effective dose of 11C-GMOM is at the lower end of the range seen for other 11C-labeled ligands, allowing for serial PET scanning in a single subject.

Original languageEnglish
Pages (from-to)1330-1333
Number of pages4
JournalJournal of Nuclear Medicine
Volume58
Issue number8
DOIs
Publication statusPublished - 1 Aug 2017

Cite this

@article{eb65fd28d6584dd59669711dad40ca6d,
title = "Human dosimetry of the n-methyl-d-aspartate receptor ligand 11C-GMOM",
abstract = "The methylguaniDine derivative 11C-GMOM (11C-labeled N-(2-chloro-3-thiomethylphenyl)-N9-(3-methoxyphenyl)-N9-methylguaniDine) has been used successfully to quantify N-methyl-D-aspartate (NMDA) receptor binDing in humans. The purpose of the present study was to estimate the 11C-GMOM raDiation dose in healthy humans. Methods: After 11C-GMOM injection, 3 female and 2 male subjects underwent 10 consecutive whole-body PET scans in approximately 77 min. Seven source organs were defined manually, scaled to a sex-specific reference, and residence times were calculated for input into OLINDA/EXM software. Accepted tissue-weighting factors were used to calculate the effective dose. Results: The mean absorbed raDiation doses in source organs ranged from 7.7 mGy-MBq21 in the brain to 12.7 mGy-MBq21 in the spleen. The effective dose (6SD) was 4.5 6 0.5 mSv-MBq21. Conclusion: The effective dose of 11C-GMOM is at the lower end of the range seen for other 11C-labeled ligands, allowing for serial PET scanning in a single subject.",
keywords = "C, Dosimetry, NMDA, PET",
author = "{Van Der Aart}, Jasper and {Van Der Doef}, {Thalia F.} and Paul Horstman and Huisman, {Marc C.} and Schuit, {Robert C.} and {Van Lingen}, Arthur and Windhorst, {Albert D.} and {Van Berckel}, {Bart N.M.} and Lammertsma, {Adriaan A.}",
year = "2017",
month = "8",
day = "1",
doi = "10.2967/jnumed.116.188250",
language = "English",
volume = "58",
pages = "1330--1333",
journal = "Journal of Nuclear Medicine",
issn = "0161-5505",
publisher = "Society of Nuclear Medicine Inc.",
number = "8",

}

Human dosimetry of the n-methyl-d-aspartate receptor ligand 11C-GMOM. / Van Der Aart, Jasper; Van Der Doef, Thalia F.; Horstman, Paul; Huisman, Marc C.; Schuit, Robert C.; Van Lingen, Arthur; Windhorst, Albert D.; Van Berckel, Bart N.M.; Lammertsma, Adriaan A.

In: Journal of Nuclear Medicine, Vol. 58, No. 8, 01.08.2017, p. 1330-1333.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Human dosimetry of the n-methyl-d-aspartate receptor ligand 11C-GMOM

AU - Van Der Aart, Jasper

AU - Van Der Doef, Thalia F.

AU - Horstman, Paul

AU - Huisman, Marc C.

AU - Schuit, Robert C.

AU - Van Lingen, Arthur

AU - Windhorst, Albert D.

AU - Van Berckel, Bart N.M.

AU - Lammertsma, Adriaan A.

PY - 2017/8/1

Y1 - 2017/8/1

N2 - The methylguaniDine derivative 11C-GMOM (11C-labeled N-(2-chloro-3-thiomethylphenyl)-N9-(3-methoxyphenyl)-N9-methylguaniDine) has been used successfully to quantify N-methyl-D-aspartate (NMDA) receptor binDing in humans. The purpose of the present study was to estimate the 11C-GMOM raDiation dose in healthy humans. Methods: After 11C-GMOM injection, 3 female and 2 male subjects underwent 10 consecutive whole-body PET scans in approximately 77 min. Seven source organs were defined manually, scaled to a sex-specific reference, and residence times were calculated for input into OLINDA/EXM software. Accepted tissue-weighting factors were used to calculate the effective dose. Results: The mean absorbed raDiation doses in source organs ranged from 7.7 mGy-MBq21 in the brain to 12.7 mGy-MBq21 in the spleen. The effective dose (6SD) was 4.5 6 0.5 mSv-MBq21. Conclusion: The effective dose of 11C-GMOM is at the lower end of the range seen for other 11C-labeled ligands, allowing for serial PET scanning in a single subject.

AB - The methylguaniDine derivative 11C-GMOM (11C-labeled N-(2-chloro-3-thiomethylphenyl)-N9-(3-methoxyphenyl)-N9-methylguaniDine) has been used successfully to quantify N-methyl-D-aspartate (NMDA) receptor binDing in humans. The purpose of the present study was to estimate the 11C-GMOM raDiation dose in healthy humans. Methods: After 11C-GMOM injection, 3 female and 2 male subjects underwent 10 consecutive whole-body PET scans in approximately 77 min. Seven source organs were defined manually, scaled to a sex-specific reference, and residence times were calculated for input into OLINDA/EXM software. Accepted tissue-weighting factors were used to calculate the effective dose. Results: The mean absorbed raDiation doses in source organs ranged from 7.7 mGy-MBq21 in the brain to 12.7 mGy-MBq21 in the spleen. The effective dose (6SD) was 4.5 6 0.5 mSv-MBq21. Conclusion: The effective dose of 11C-GMOM is at the lower end of the range seen for other 11C-labeled ligands, allowing for serial PET scanning in a single subject.

KW - C

KW - Dosimetry

KW - NMDA

KW - PET

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U2 - 10.2967/jnumed.116.188250

DO - 10.2967/jnumed.116.188250

M3 - Article

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SP - 1330

EP - 1333

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

SN - 0161-5505

IS - 8

ER -