TY - JOUR
T1 - Human dosimetry of the n-methyl-d-aspartate receptor ligand 11C-GMOM
AU - Van Der Aart, Jasper
AU - Van Der Doef, Thalia F.
AU - Horstman, Paul
AU - Huisman, Marc C.
AU - Schuit, Robert C.
AU - Van Lingen, Arthur
AU - Windhorst, Albert D.
AU - Van Berckel, Bart N.M.
AU - Lammertsma, Adriaan A.
PY - 2017/8/1
Y1 - 2017/8/1
N2 - The methylguaniDine derivative 11C-GMOM (11C-labeled N-(2-chloro-3-thiomethylphenyl)-N9-(3-methoxyphenyl)-N9-methylguaniDine) has been used successfully to quantify N-methyl-D-aspartate (NMDA) receptor binDing in humans. The purpose of the present study was to estimate the 11C-GMOM raDiation dose in healthy humans. Methods: After 11C-GMOM injection, 3 female and 2 male subjects underwent 10 consecutive whole-body PET scans in approximately 77 min. Seven source organs were defined manually, scaled to a sex-specific reference, and residence times were calculated for input into OLINDA/EXM software. Accepted tissue-weighting factors were used to calculate the effective dose. Results: The mean absorbed raDiation doses in source organs ranged from 7.7 mGy-MBq21 in the brain to 12.7 mGy-MBq21 in the spleen. The effective dose (6SD) was 4.5 6 0.5 mSv-MBq21. Conclusion: The effective dose of 11C-GMOM is at the lower end of the range seen for other 11C-labeled ligands, allowing for serial PET scanning in a single subject.
AB - The methylguaniDine derivative 11C-GMOM (11C-labeled N-(2-chloro-3-thiomethylphenyl)-N9-(3-methoxyphenyl)-N9-methylguaniDine) has been used successfully to quantify N-methyl-D-aspartate (NMDA) receptor binDing in humans. The purpose of the present study was to estimate the 11C-GMOM raDiation dose in healthy humans. Methods: After 11C-GMOM injection, 3 female and 2 male subjects underwent 10 consecutive whole-body PET scans in approximately 77 min. Seven source organs were defined manually, scaled to a sex-specific reference, and residence times were calculated for input into OLINDA/EXM software. Accepted tissue-weighting factors were used to calculate the effective dose. Results: The mean absorbed raDiation doses in source organs ranged from 7.7 mGy-MBq21 in the brain to 12.7 mGy-MBq21 in the spleen. The effective dose (6SD) was 4.5 6 0.5 mSv-MBq21. Conclusion: The effective dose of 11C-GMOM is at the lower end of the range seen for other 11C-labeled ligands, allowing for serial PET scanning in a single subject.
KW - C
KW - Dosimetry
KW - NMDA
KW - PET
UR - http://www.scopus.com/inward/record.url?scp=85026499530&partnerID=8YFLogxK
U2 - 10.2967/jnumed.116.188250
DO - 10.2967/jnumed.116.188250
M3 - Article
C2 - 28183990
AN - SCOPUS:85026499530
VL - 58
SP - 1330
EP - 1333
JO - Journal of Nuclear Medicine
JF - Journal of Nuclear Medicine
SN - 0161-5505
IS - 8
ER -