Human dosimetry of the n-methyl-d-aspartate receptor ligand 11C-GMOM

Jasper Van Der Aart; Thalia F. Van Der Doef; Paul Horstman; Marc C. Huisman; Robert C. Schuit; Arthur Van Lingen; Albert D. Windhorst; Bart N.M. Van Berckel; Adriaan A. Lammertsma

doi:10.2967/jnumed.116.188250

Human dosimetry of the n-methyl-d-aspartate receptor ligand ¹¹C-GMOM

Jasper Van Der Aart, Thalia F. Van Der Doef, Paul Horstman, Marc C. Huisman, Robert C. Schuit, Arthur Van Lingen, Albert D. Windhorst, Bart N.M. Van Berckel, Adriaan A. Lammertsma

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The methylguaniDine derivative ¹¹C-GMOM (¹¹C-labeled N-(2-chloro-3-thiomethylphenyl)-N9-(3-methoxyphenyl)-N9-methylguaniDine) has been used successfully to quantify N-methyl-D-aspartate (NMDA) receptor binDing in humans. The purpose of the present study was to estimate the ¹¹C-GMOM raDiation dose in healthy humans. Methods: After ¹¹C-GMOM injection, 3 female and 2 male subjects underwent 10 consecutive whole-body PET scans in approximately 77 min. Seven source organs were defined manually, scaled to a sex-specific reference, and residence times were calculated for input into OLINDA/EXM software. Accepted tissue-weighting factors were used to calculate the effective dose. Results: The mean absorbed raDiation doses in source organs ranged from 7.7 mGy-MBq21 in the brain to 12.7 mGy-MBq21 in the spleen. The effective dose (6SD) was 4.5 6 0.5 mSv-MBq21. Conclusion: The effective dose of ¹¹C-GMOM is at the lower end of the range seen for other ¹¹C-labeled ligands, allowing for serial PET scanning in a single subject.

Original language	English
Pages (from-to)	1330-1333
Number of pages	4
Journal	Journal of Nuclear Medicine
Volume	58
Issue number	8
DOIs	https://doi.org/10.2967/jnumed.116.188250
Publication status	Published - 1 Aug 2017

Cite this

Van Der Aart, J., Van Der Doef, T. F., Horstman, P., Huisman, M. C., Schuit, R. C., Van Lingen, A., ... Lammertsma, A. A. (2017). Human dosimetry of the n-methyl-d-aspartate receptor ligand ¹¹C-GMOM. Journal of Nuclear Medicine, 58(8), 1330-1333. https://doi.org/10.2967/jnumed.116.188250

Van Der Aart, Jasper ; Van Der Doef, Thalia F. ; Horstman, Paul ; Huisman, Marc C. ; Schuit, Robert C. ; Van Lingen, Arthur ; Windhorst, Albert D. ; Van Berckel, Bart N.M. ; Lammertsma, Adriaan A. / Human dosimetry of the n-methyl-d-aspartate receptor ligand ¹¹C-GMOM. In: Journal of Nuclear Medicine. 2017 ; Vol. 58, No. 8. pp. 1330-1333.

@article{eb65fd28d6584dd59669711dad40ca6d,

title = "Human dosimetry of the n-methyl-d-aspartate receptor ligand 11C-GMOM",

abstract = "The methylguaniDine derivative 11C-GMOM (11C-labeled N-(2-chloro-3-thiomethylphenyl)-N9-(3-methoxyphenyl)-N9-methylguaniDine) has been used successfully to quantify N-methyl-D-aspartate (NMDA) receptor binDing in humans. The purpose of the present study was to estimate the 11C-GMOM raDiation dose in healthy humans. Methods: After 11C-GMOM injection, 3 female and 2 male subjects underwent 10 consecutive whole-body PET scans in approximately 77 min. Seven source organs were defined manually, scaled to a sex-specific reference, and residence times were calculated for input into OLINDA/EXM software. Accepted tissue-weighting factors were used to calculate the effective dose. Results: The mean absorbed raDiation doses in source organs ranged from 7.7 mGy-MBq21 in the brain to 12.7 mGy-MBq21 in the spleen. The effective dose (6SD) was 4.5 6 0.5 mSv-MBq21. Conclusion: The effective dose of 11C-GMOM is at the lower end of the range seen for other 11C-labeled ligands, allowing for serial PET scanning in a single subject.",

keywords = "C, Dosimetry, NMDA, PET",

author = "{Van Der Aart}, Jasper and {Van Der Doef}, {Thalia F.} and Paul Horstman and Huisman, {Marc C.} and Schuit, {Robert C.} and {Van Lingen}, Arthur and Windhorst, {Albert D.} and {Van Berckel}, {Bart N.M.} and Lammertsma, {Adriaan A.}",

year = "2017",

month = "8",

day = "1",

doi = "10.2967/jnumed.116.188250",

language = "English",

volume = "58",

pages = "1330--1333",

journal = "Journal of Nuclear Medicine",

issn = "0161-5505",

publisher = "Society of Nuclear Medicine Inc.",

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}

Van Der Aart, J, Van Der Doef, TF, Horstman, P, Huisman, MC , Schuit, RC , Van Lingen, A , Windhorst, AD , Van Berckel, BNM & Lammertsma, AA 2017, 'Human dosimetry of the n-methyl-d-aspartate receptor ligand ¹¹C-GMOM' Journal of Nuclear Medicine, vol. 58, no. 8, pp. 1330-1333. https://doi.org/10.2967/jnumed.116.188250

Human dosimetry of the n-methyl-d-aspartate receptor ligand ¹¹C-GMOM. / Van Der Aart, Jasper; Van Der Doef, Thalia F.; Horstman, Paul; Huisman, Marc C.; Schuit, Robert C.; Van Lingen, Arthur ; Windhorst, Albert D.; Van Berckel, Bart N.M.; Lammertsma, Adriaan A.

In: Journal of Nuclear Medicine, Vol. 58, No. 8, 01.08.2017, p. 1330-1333.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Human dosimetry of the n-methyl-d-aspartate receptor ligand 11C-GMOM

AU - Van Der Aart, Jasper

AU - Van Der Doef, Thalia F.

AU - Horstman, Paul

AU - Huisman, Marc C.

AU - Schuit, Robert C.

AU - Van Lingen, Arthur

AU - Windhorst, Albert D.

AU - Van Berckel, Bart N.M.

AU - Lammertsma, Adriaan A.

PY - 2017/8/1

Y1 - 2017/8/1

N2 - The methylguaniDine derivative 11C-GMOM (11C-labeled N-(2-chloro-3-thiomethylphenyl)-N9-(3-methoxyphenyl)-N9-methylguaniDine) has been used successfully to quantify N-methyl-D-aspartate (NMDA) receptor binDing in humans. The purpose of the present study was to estimate the 11C-GMOM raDiation dose in healthy humans. Methods: After 11C-GMOM injection, 3 female and 2 male subjects underwent 10 consecutive whole-body PET scans in approximately 77 min. Seven source organs were defined manually, scaled to a sex-specific reference, and residence times were calculated for input into OLINDA/EXM software. Accepted tissue-weighting factors were used to calculate the effective dose. Results: The mean absorbed raDiation doses in source organs ranged from 7.7 mGy-MBq21 in the brain to 12.7 mGy-MBq21 in the spleen. The effective dose (6SD) was 4.5 6 0.5 mSv-MBq21. Conclusion: The effective dose of 11C-GMOM is at the lower end of the range seen for other 11C-labeled ligands, allowing for serial PET scanning in a single subject.

AB - The methylguaniDine derivative 11C-GMOM (11C-labeled N-(2-chloro-3-thiomethylphenyl)-N9-(3-methoxyphenyl)-N9-methylguaniDine) has been used successfully to quantify N-methyl-D-aspartate (NMDA) receptor binDing in humans. The purpose of the present study was to estimate the 11C-GMOM raDiation dose in healthy humans. Methods: After 11C-GMOM injection, 3 female and 2 male subjects underwent 10 consecutive whole-body PET scans in approximately 77 min. Seven source organs were defined manually, scaled to a sex-specific reference, and residence times were calculated for input into OLINDA/EXM software. Accepted tissue-weighting factors were used to calculate the effective dose. Results: The mean absorbed raDiation doses in source organs ranged from 7.7 mGy-MBq21 in the brain to 12.7 mGy-MBq21 in the spleen. The effective dose (6SD) was 4.5 6 0.5 mSv-MBq21. Conclusion: The effective dose of 11C-GMOM is at the lower end of the range seen for other 11C-labeled ligands, allowing for serial PET scanning in a single subject.

KW - C

KW - Dosimetry

KW - NMDA

KW - PET

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U2 - 10.2967/jnumed.116.188250

DO - 10.2967/jnumed.116.188250

M3 - Article

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JO - Journal of Nuclear Medicine