Human natural killer T cells acquire a memory-activated phenotype before birth

H J van Der Vliet, N Nishi, T D de Gruijl, B M von Blomberg, A J van den Eertwegh, H M Pinedo, G Giaccone, R J Scheper

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Natural killer T (NKT) cells have recently been shown to play an important role in the rejection of malignant tumors and in the regulation of autoimmune diseases. Potent antitumor effects of the marine sponge-derived NKT cell ligand KRN7000 were observed in mice. Therefore, the elucidation of the natural ligand of NKT cells, which is currently still unknown, might have important clinical consequences for the treatment of cancer and autoimmune diseases. Analysis of cord blood mononuclear cells from healthy term infants demonstrated that in sharp contrast with the vast majority of cord blood lymphocytes, human NKT cells have already acquired a memory-activated phenotype before birth. This observation indicates that NKT cells encounter a natural ligand during fetal life and that this ligand is unlikely to be of microbial origin.

Original languageEnglish
Pages (from-to)2440-2
Number of pages3
JournalBlood
Volume95
Issue number7
Publication statusPublished - 1 Apr 2000

Cite this

van Der Vliet, H J ; Nishi, N ; de Gruijl, T D ; von Blomberg, B M ; van den Eertwegh, A J ; Pinedo, H M ; Giaccone, G ; Scheper, R J. / Human natural killer T cells acquire a memory-activated phenotype before birth. In: Blood. 2000 ; Vol. 95, No. 7. pp. 2440-2.
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title = "Human natural killer T cells acquire a memory-activated phenotype before birth",
abstract = "Natural killer T (NKT) cells have recently been shown to play an important role in the rejection of malignant tumors and in the regulation of autoimmune diseases. Potent antitumor effects of the marine sponge-derived NKT cell ligand KRN7000 were observed in mice. Therefore, the elucidation of the natural ligand of NKT cells, which is currently still unknown, might have important clinical consequences for the treatment of cancer and autoimmune diseases. Analysis of cord blood mononuclear cells from healthy term infants demonstrated that in sharp contrast with the vast majority of cord blood lymphocytes, human NKT cells have already acquired a memory-activated phenotype before birth. This observation indicates that NKT cells encounter a natural ligand during fetal life and that this ligand is unlikely to be of microbial origin.",
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author = "{van Der Vliet}, {H J} and N Nishi and {de Gruijl}, {T D} and {von Blomberg}, {B M} and {van den Eertwegh}, {A J} and Pinedo, {H M} and G Giaccone and Scheper, {R J}",
year = "2000",
month = "4",
day = "1",
language = "English",
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journal = "Blood",
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Human natural killer T cells acquire a memory-activated phenotype before birth. / van Der Vliet, H J; Nishi, N; de Gruijl, T D; von Blomberg, B M; van den Eertwegh, A J; Pinedo, H M; Giaccone, G; Scheper, R J.

In: Blood, Vol. 95, No. 7, 01.04.2000, p. 2440-2.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Human natural killer T cells acquire a memory-activated phenotype before birth

AU - van Der Vliet, H J

AU - Nishi, N

AU - de Gruijl, T D

AU - von Blomberg, B M

AU - van den Eertwegh, A J

AU - Pinedo, H M

AU - Giaccone, G

AU - Scheper, R J

PY - 2000/4/1

Y1 - 2000/4/1

N2 - Natural killer T (NKT) cells have recently been shown to play an important role in the rejection of malignant tumors and in the regulation of autoimmune diseases. Potent antitumor effects of the marine sponge-derived NKT cell ligand KRN7000 were observed in mice. Therefore, the elucidation of the natural ligand of NKT cells, which is currently still unknown, might have important clinical consequences for the treatment of cancer and autoimmune diseases. Analysis of cord blood mononuclear cells from healthy term infants demonstrated that in sharp contrast with the vast majority of cord blood lymphocytes, human NKT cells have already acquired a memory-activated phenotype before birth. This observation indicates that NKT cells encounter a natural ligand during fetal life and that this ligand is unlikely to be of microbial origin.

AB - Natural killer T (NKT) cells have recently been shown to play an important role in the rejection of malignant tumors and in the regulation of autoimmune diseases. Potent antitumor effects of the marine sponge-derived NKT cell ligand KRN7000 were observed in mice. Therefore, the elucidation of the natural ligand of NKT cells, which is currently still unknown, might have important clinical consequences for the treatment of cancer and autoimmune diseases. Analysis of cord blood mononuclear cells from healthy term infants demonstrated that in sharp contrast with the vast majority of cord blood lymphocytes, human NKT cells have already acquired a memory-activated phenotype before birth. This observation indicates that NKT cells encounter a natural ligand during fetal life and that this ligand is unlikely to be of microbial origin.

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KW - Female

KW - Fetal Blood/cytology

KW - Humans

KW - Immunologic Memory

KW - Immunophenotyping

KW - Infant, Newborn

KW - Killer Cells, Natural/immunology

KW - L-Selectin/analysis

KW - Leukocyte Common Antigens/analysis

KW - Male

KW - Phenotype

KW - Receptors, Interleukin-2/analysis

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EP - 2442

JO - Blood

JF - Blood

SN - 0006-4971

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