Humaan papillomavirus en het ontstaan van baarmoederhalskanker: Concept van carcinogenese

Translated title of the contribution: Human papilloma virus and development of cervical carcinoma: The concept of carcinogenesis

J. M.M. Walboomers, C. J.L.M. Meijer, R. D.M. Steenbergen, M. Van Duin, Th J.M. Helmerhorst, P. J.F. Snijders*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Infection with high risk human papillomavirus (hrHPV) plays a central aetiological role in cervical cancer. Still, cervical carcinogenesis is a multistep process which requires other events in addition to hrHPV infection. Recent data have resulted in the following concept of cervical carcinogenesis: hrHPV infects normal squamous epithelium. In most cases this will not lead to a lesion or at worst give rise to a regressing low grade cervical intraepithelial neoplasia (CIN). Both phenomena involve viral clearance. Only persistent hrHPV infections will lead to a high grade CIN lesion, a subset of which may undergo malignant transformation. At the transition of CIN 2 to CIN 3 deregulated expression of the viral oncogenes E6 and E7 takes place, resulting in genetic instability. Subsequently, activation of the telomere-lengthening enzyme, telomerase occurs, as the result of which cells obtain an infinite replication capacity. Ultimately, successive allele losses occur at different chromosomal locations which, followed by a clonal outgrowth result in an invasive carcinoma.

Translated title of the contributionHuman papilloma virus and development of cervical carcinoma: The concept of carcinogenesis
Original languageDutch
Pages (from-to)1671-1674
Number of pages4
JournalNederlands Tijdschrift voor Geneeskunde
Issue number35
Publication statusPublished - 26 Aug 2000

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