Hyperoxia does not affect oxygen delivery in healthy volunteers while causing a decrease in sublingual perfusion

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Abstract

Objective: To determine the human dose-response relationship between a stepwise increase in arterial oxygen tension and its associated changes in DO2 and sublingual microcirculatory perfusion. Methods: Fifteen healthy volunteers breathed increasing oxygen fractions for 10 minutes to reach arterial oxygen tensions of baseline (breathing air), 20, 40, 60 kPa, and max kPa (breathing oxygen). Systemic hemodynamics were measured continuously by the volume-clamp method. At the end of each period, the sublingual microcirculation was assessed by SDF. Results: Systemic DO2 was unchanged throughout the study (Pslope =.8). PVD decreased in a sigmoidal fashion (max −15% while breathing oxygen, SD18, Pslope =.001). CI decreased linearly (max −10%, SD10, Pslope <.001) due to a reduction in HR (max −10%, SD7, Pslope =.009). There were no changes in stroke volume or MAP. Most changes became apparent above an arterial oxygen tension of 20 kPa. Conclusions: In healthy volunteers, supraphysiological arterial oxygen tensions have no effect on systemic DO2. Sublingual microcirculatory PVD decreased in a dose-dependent fashion. All hemodynamic changes appear negligible up to an arterial oxygen tension of 20 kPa.

Original languageEnglish
Article numbere12433
JournalMicrocirculation
Volume25
Issue number2
DOIs
Publication statusPublished - 1 Feb 2018

Cite this

@article{13dcb65d049945c8bc28665ffa10dc41,
title = "Hyperoxia does not affect oxygen delivery in healthy volunteers while causing a decrease in sublingual perfusion",
abstract = "Objective: To determine the human dose-response relationship between a stepwise increase in arterial oxygen tension and its associated changes in DO2 and sublingual microcirculatory perfusion. Methods: Fifteen healthy volunteers breathed increasing oxygen fractions for 10 minutes to reach arterial oxygen tensions of baseline (breathing air), 20, 40, 60 kPa, and max kPa (breathing oxygen). Systemic hemodynamics were measured continuously by the volume-clamp method. At the end of each period, the sublingual microcirculation was assessed by SDF. Results: Systemic DO2 was unchanged throughout the study (Pslope =.8). PVD decreased in a sigmoidal fashion (max −15{\%} while breathing oxygen, SD18, Pslope =.001). CI decreased linearly (max −10{\%}, SD10, Pslope <.001) due to a reduction in HR (max −10{\%}, SD7, Pslope =.009). There were no changes in stroke volume or MAP. Most changes became apparent above an arterial oxygen tension of 20 kPa. Conclusions: In healthy volunteers, supraphysiological arterial oxygen tensions have no effect on systemic DO2. Sublingual microcirculatory PVD decreased in a dose-dependent fashion. All hemodynamic changes appear negligible up to an arterial oxygen tension of 20 kPa.",
keywords = "dose response, healthy volunteers, hyperoxia, microcirculation, oxygen, oxygen delivery",
author = "Bob Smit and Smulders, {Yvo M.} and Eringa, {Etto C.} and Gelissen, {Harry P.M.M.} and Girbes, {Armand R.J.} and {de Grooth}, {Harm Jan S.} and Schotman, {Hans H.M.} and Scheffer, {Peter G.} and {Oudemans-van Straaten}, {Heleen M.} and {Spoelstra-de Man}, {Angelique M.E.}",
year = "2018",
month = "2",
day = "1",
doi = "10.1111/micc.12433",
language = "English",
volume = "25",
journal = "Microcirculation",
issn = "1073-9688",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Hyperoxia does not affect oxygen delivery in healthy volunteers while causing a decrease in sublingual perfusion

AU - Smit, Bob

AU - Smulders, Yvo M.

AU - Eringa, Etto C.

AU - Gelissen, Harry P.M.M.

AU - Girbes, Armand R.J.

AU - de Grooth, Harm Jan S.

AU - Schotman, Hans H.M.

AU - Scheffer, Peter G.

AU - Oudemans-van Straaten, Heleen M.

AU - Spoelstra-de Man, Angelique M.E.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Objective: To determine the human dose-response relationship between a stepwise increase in arterial oxygen tension and its associated changes in DO2 and sublingual microcirculatory perfusion. Methods: Fifteen healthy volunteers breathed increasing oxygen fractions for 10 minutes to reach arterial oxygen tensions of baseline (breathing air), 20, 40, 60 kPa, and max kPa (breathing oxygen). Systemic hemodynamics were measured continuously by the volume-clamp method. At the end of each period, the sublingual microcirculation was assessed by SDF. Results: Systemic DO2 was unchanged throughout the study (Pslope =.8). PVD decreased in a sigmoidal fashion (max −15% while breathing oxygen, SD18, Pslope =.001). CI decreased linearly (max −10%, SD10, Pslope <.001) due to a reduction in HR (max −10%, SD7, Pslope =.009). There were no changes in stroke volume or MAP. Most changes became apparent above an arterial oxygen tension of 20 kPa. Conclusions: In healthy volunteers, supraphysiological arterial oxygen tensions have no effect on systemic DO2. Sublingual microcirculatory PVD decreased in a dose-dependent fashion. All hemodynamic changes appear negligible up to an arterial oxygen tension of 20 kPa.

AB - Objective: To determine the human dose-response relationship between a stepwise increase in arterial oxygen tension and its associated changes in DO2 and sublingual microcirculatory perfusion. Methods: Fifteen healthy volunteers breathed increasing oxygen fractions for 10 minutes to reach arterial oxygen tensions of baseline (breathing air), 20, 40, 60 kPa, and max kPa (breathing oxygen). Systemic hemodynamics were measured continuously by the volume-clamp method. At the end of each period, the sublingual microcirculation was assessed by SDF. Results: Systemic DO2 was unchanged throughout the study (Pslope =.8). PVD decreased in a sigmoidal fashion (max −15% while breathing oxygen, SD18, Pslope =.001). CI decreased linearly (max −10%, SD10, Pslope <.001) due to a reduction in HR (max −10%, SD7, Pslope =.009). There were no changes in stroke volume or MAP. Most changes became apparent above an arterial oxygen tension of 20 kPa. Conclusions: In healthy volunteers, supraphysiological arterial oxygen tensions have no effect on systemic DO2. Sublingual microcirculatory PVD decreased in a dose-dependent fashion. All hemodynamic changes appear negligible up to an arterial oxygen tension of 20 kPa.

KW - dose response

KW - healthy volunteers

KW - hyperoxia

KW - microcirculation

KW - oxygen

KW - oxygen delivery

UR - http://www.scopus.com/inward/record.url?scp=85041909474&partnerID=8YFLogxK

U2 - 10.1111/micc.12433

DO - 10.1111/micc.12433

M3 - Article

VL - 25

JO - Microcirculation

JF - Microcirculation

SN - 1073-9688

IS - 2

M1 - e12433

ER -