Hypertension is related to the microstructure of the corpus callosum: the RUN DMC study

Rob A R Gons, Lucas J B van Oudheusden, Karlijn F de Laat, Anouk G W van Norden, Inge W M van Uden, David G Norris, Marcel P Zwiers, Ewoud van Dijk, Frank-Erik de Leeuw

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Vascular factors play a role in the etiology of Alzheimer's disease (AD), presumably due to emergence of white matter lesions. However, important white matter structures involved in the etiology of AD, including the corpus callosum (CC), remain invariably free from macroscopical white matter lesions, although loss of microstructural integrity assessed with diffusion tensor imaging (DTI) has been described in the CC. Vascular factors have been related to these microstructural white matter changes too, but little is known about their effect on the CC. In 499 subjects with cerebral small vessel disease, aged 50-85 years, we cross-sectionally investigated the relation between hypertension, hypertension treatment status, the microstructural integrity of the CC using DTI, and the attendant cognitive performance. Fractional anisotropy and mean diffusivity were calculated in four substructures of the CC (genu, anterior body, posterior body, and splenium). Differences between groups were calculated with analysis of variance, adjusted for age, gender, and cardiovascular risk factors. Compared with normotensive subjects, hypertensive subjects had a lower fractional anisotropy in the splenium and a significant higher mean diffusivity in both the anterior body and the splenium; this was most noticeable in treated uncontrolled hypertensive subjects. Furthermore we found that microstructural integrity of the CC was related to global cognition. Of this relation, 14 to 60% was explained by the mediating effect of small vessel disease elsewhere in the white matter. Our findings indicate that adequate blood pressure treatment might postpone these changes and the attendant cognitive dysfunction.

Original languageEnglish
Pages (from-to)623-31
Number of pages9
JournalJournal of Alzheimer's Disease
Volume32
Issue number3
DOIs
Publication statusPublished - 2012

Cite this

Gons, R. A. R., van Oudheusden, L. J. B., de Laat, K. F., van Norden, A. G. W., van Uden, I. W. M., Norris, D. G., ... de Leeuw, F-E. (2012). Hypertension is related to the microstructure of the corpus callosum: the RUN DMC study. Journal of Alzheimer's Disease, 32(3), 623-31. https://doi.org/10.3233/JAD-2012-121006
Gons, Rob A R ; van Oudheusden, Lucas J B ; de Laat, Karlijn F ; van Norden, Anouk G W ; van Uden, Inge W M ; Norris, David G ; Zwiers, Marcel P ; van Dijk, Ewoud ; de Leeuw, Frank-Erik. / Hypertension is related to the microstructure of the corpus callosum : the RUN DMC study. In: Journal of Alzheimer's Disease. 2012 ; Vol. 32, No. 3. pp. 623-31.
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abstract = "Vascular factors play a role in the etiology of Alzheimer's disease (AD), presumably due to emergence of white matter lesions. However, important white matter structures involved in the etiology of AD, including the corpus callosum (CC), remain invariably free from macroscopical white matter lesions, although loss of microstructural integrity assessed with diffusion tensor imaging (DTI) has been described in the CC. Vascular factors have been related to these microstructural white matter changes too, but little is known about their effect on the CC. In 499 subjects with cerebral small vessel disease, aged 50-85 years, we cross-sectionally investigated the relation between hypertension, hypertension treatment status, the microstructural integrity of the CC using DTI, and the attendant cognitive performance. Fractional anisotropy and mean diffusivity were calculated in four substructures of the CC (genu, anterior body, posterior body, and splenium). Differences between groups were calculated with analysis of variance, adjusted for age, gender, and cardiovascular risk factors. Compared with normotensive subjects, hypertensive subjects had a lower fractional anisotropy in the splenium and a significant higher mean diffusivity in both the anterior body and the splenium; this was most noticeable in treated uncontrolled hypertensive subjects. Furthermore we found that microstructural integrity of the CC was related to global cognition. Of this relation, 14 to 60{\%} was explained by the mediating effect of small vessel disease elsewhere in the white matter. Our findings indicate that adequate blood pressure treatment might postpone these changes and the attendant cognitive dysfunction.",
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Gons, RAR, van Oudheusden, LJB, de Laat, KF, van Norden, AGW, van Uden, IWM, Norris, DG, Zwiers, MP, van Dijk, E & de Leeuw, F-E 2012, 'Hypertension is related to the microstructure of the corpus callosum: the RUN DMC study' Journal of Alzheimer's Disease, vol. 32, no. 3, pp. 623-31. https://doi.org/10.3233/JAD-2012-121006

Hypertension is related to the microstructure of the corpus callosum : the RUN DMC study. / Gons, Rob A R; van Oudheusden, Lucas J B; de Laat, Karlijn F; van Norden, Anouk G W; van Uden, Inge W M; Norris, David G; Zwiers, Marcel P; van Dijk, Ewoud; de Leeuw, Frank-Erik.

In: Journal of Alzheimer's Disease, Vol. 32, No. 3, 2012, p. 623-31.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Hypertension is related to the microstructure of the corpus callosum

T2 - the RUN DMC study

AU - Gons, Rob A R

AU - van Oudheusden, Lucas J B

AU - de Laat, Karlijn F

AU - van Norden, Anouk G W

AU - van Uden, Inge W M

AU - Norris, David G

AU - Zwiers, Marcel P

AU - van Dijk, Ewoud

AU - de Leeuw, Frank-Erik

PY - 2012

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N2 - Vascular factors play a role in the etiology of Alzheimer's disease (AD), presumably due to emergence of white matter lesions. However, important white matter structures involved in the etiology of AD, including the corpus callosum (CC), remain invariably free from macroscopical white matter lesions, although loss of microstructural integrity assessed with diffusion tensor imaging (DTI) has been described in the CC. Vascular factors have been related to these microstructural white matter changes too, but little is known about their effect on the CC. In 499 subjects with cerebral small vessel disease, aged 50-85 years, we cross-sectionally investigated the relation between hypertension, hypertension treatment status, the microstructural integrity of the CC using DTI, and the attendant cognitive performance. Fractional anisotropy and mean diffusivity were calculated in four substructures of the CC (genu, anterior body, posterior body, and splenium). Differences between groups were calculated with analysis of variance, adjusted for age, gender, and cardiovascular risk factors. Compared with normotensive subjects, hypertensive subjects had a lower fractional anisotropy in the splenium and a significant higher mean diffusivity in both the anterior body and the splenium; this was most noticeable in treated uncontrolled hypertensive subjects. Furthermore we found that microstructural integrity of the CC was related to global cognition. Of this relation, 14 to 60% was explained by the mediating effect of small vessel disease elsewhere in the white matter. Our findings indicate that adequate blood pressure treatment might postpone these changes and the attendant cognitive dysfunction.

AB - Vascular factors play a role in the etiology of Alzheimer's disease (AD), presumably due to emergence of white matter lesions. However, important white matter structures involved in the etiology of AD, including the corpus callosum (CC), remain invariably free from macroscopical white matter lesions, although loss of microstructural integrity assessed with diffusion tensor imaging (DTI) has been described in the CC. Vascular factors have been related to these microstructural white matter changes too, but little is known about their effect on the CC. In 499 subjects with cerebral small vessel disease, aged 50-85 years, we cross-sectionally investigated the relation between hypertension, hypertension treatment status, the microstructural integrity of the CC using DTI, and the attendant cognitive performance. Fractional anisotropy and mean diffusivity were calculated in four substructures of the CC (genu, anterior body, posterior body, and splenium). Differences between groups were calculated with analysis of variance, adjusted for age, gender, and cardiovascular risk factors. Compared with normotensive subjects, hypertensive subjects had a lower fractional anisotropy in the splenium and a significant higher mean diffusivity in both the anterior body and the splenium; this was most noticeable in treated uncontrolled hypertensive subjects. Furthermore we found that microstructural integrity of the CC was related to global cognition. Of this relation, 14 to 60% was explained by the mediating effect of small vessel disease elsewhere in the white matter. Our findings indicate that adequate blood pressure treatment might postpone these changes and the attendant cognitive dysfunction.

KW - Aged

KW - Aged, 80 and over

KW - Cognition Disorders/epidemiology

KW - Cohort Studies

KW - Corpus Callosum/metabolism

KW - Diffusion Tensor Imaging/methods

KW - Female

KW - Humans

KW - Hypertension/epidemiology

KW - Male

KW - Middle Aged

KW - Nerve Fibers, Myelinated/metabolism

KW - Netherlands/epidemiology

KW - Neuropsychological Tests

KW - Prospective Studies

U2 - 10.3233/JAD-2012-121006

DO - 10.3233/JAD-2012-121006

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JF - Journal of Alzheimer's Disease

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ER -