Identification and validation of a 3-gene methylation classifier for HPV-based cervical screening on self-samples

Wina Verlaat, Barbara C Snoek, Daniëlle A.M. Heideman, Saskia M Wilting, Peter J.F. Snijders, Putri W. Novianti, Annina P. van Splunter, Carel F.W. Peeters, Nienke E van Trommel, Leon F.A.G. Massuger, Ruud L.M. Bekkers, Willem JG Melchers, Folkert J. van Kemenade, Johannes Berkhof, Mark A. van de Wiel, Chris J.L.M. Meijer, Renske D.M. Steenbergen

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Offering self-sampling of cervico-vaginal material for high-risk human papillomavirus (hrHPV) testing is an effective method to increase the coverage in cervical screening programs. Molecular triage directly on hrHPV-positive self-samples for colposcopy referral opens the way to full molecular cervical screening. Here, we set out to identify a DNA methylation classifier for detection of cervical precancer (CIN3) and cancer, applicable to lavage and brush self-samples.
Original languageEnglish
Pages (from-to)clincanres.3615.2017
JournalClinical Cancer Research
DOIs
Publication statusPublished - 9 Apr 2018

Cite this

@article{36faad542c064fdbbf8a4e3fd280a53e,
title = "Identification and validation of a 3-gene methylation classifier for HPV-based cervical screening on self-samples",
abstract = "Offering self-sampling of cervico-vaginal material for high-risk human papillomavirus (hrHPV) testing is an effective method to increase the coverage in cervical screening programs. Molecular triage directly on hrHPV-positive self-samples for colposcopy referral opens the way to full molecular cervical screening. Here, we set out to identify a DNA methylation classifier for detection of cervical precancer (CIN3) and cancer, applicable to lavage and brush self-samples.",
author = "Wina Verlaat and Snoek, {Barbara C} and Heideman, {Dani{\"e}lle A.M.} and Wilting, {Saskia M} and Snijders, {Peter J.F.} and Novianti, {Putri W.} and {van Splunter}, {Annina P.} and Peeters, {Carel F.W.} and {van Trommel}, {Nienke E} and Massuger, {Leon F.A.G.} and Bekkers, {Ruud L.M.} and Melchers, {Willem JG} and {van Kemenade}, {Folkert J.} and Johannes Berkhof and {van de Wiel}, {Mark A.} and Meijer, {Chris J.L.M.} and Steenbergen, {Renske D.M.}",
year = "2018",
month = "4",
day = "9",
doi = "10.1158/1078-0432.CCR-17-3615",
language = "English",
pages = "clincanres.3615.2017",
journal = "Clinical Cancer Research",
issn = "1078-0432",
publisher = "American Association for Cancer Research Inc.",

}

Identification and validation of a 3-gene methylation classifier for HPV-based cervical screening on self-samples. / Verlaat, Wina; Snoek, Barbara C; Heideman, Daniëlle A.M.; Wilting, Saskia M; Snijders, Peter J.F.; Novianti, Putri W.; van Splunter, Annina P.; Peeters, Carel F.W.; van Trommel, Nienke E; Massuger, Leon F.A.G.; Bekkers, Ruud L.M.; Melchers, Willem JG; van Kemenade, Folkert J.; Berkhof, Johannes; van de Wiel, Mark A.; Meijer, Chris J.L.M.; Steenbergen, Renske D.M.

In: Clinical Cancer Research, 09.04.2018, p. clincanres.3615.2017.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Identification and validation of a 3-gene methylation classifier for HPV-based cervical screening on self-samples

AU - Verlaat, Wina

AU - Snoek, Barbara C

AU - Heideman, Daniëlle A.M.

AU - Wilting, Saskia M

AU - Snijders, Peter J.F.

AU - Novianti, Putri W.

AU - van Splunter, Annina P.

AU - Peeters, Carel F.W.

AU - van Trommel, Nienke E

AU - Massuger, Leon F.A.G.

AU - Bekkers, Ruud L.M.

AU - Melchers, Willem JG

AU - van Kemenade, Folkert J.

AU - Berkhof, Johannes

AU - van de Wiel, Mark A.

AU - Meijer, Chris J.L.M.

AU - Steenbergen, Renske D.M.

PY - 2018/4/9

Y1 - 2018/4/9

N2 - Offering self-sampling of cervico-vaginal material for high-risk human papillomavirus (hrHPV) testing is an effective method to increase the coverage in cervical screening programs. Molecular triage directly on hrHPV-positive self-samples for colposcopy referral opens the way to full molecular cervical screening. Here, we set out to identify a DNA methylation classifier for detection of cervical precancer (CIN3) and cancer, applicable to lavage and brush self-samples.

AB - Offering self-sampling of cervico-vaginal material for high-risk human papillomavirus (hrHPV) testing is an effective method to increase the coverage in cervical screening programs. Molecular triage directly on hrHPV-positive self-samples for colposcopy referral opens the way to full molecular cervical screening. Here, we set out to identify a DNA methylation classifier for detection of cervical precancer (CIN3) and cancer, applicable to lavage and brush self-samples.

U2 - 10.1158/1078-0432.CCR-17-3615

DO - 10.1158/1078-0432.CCR-17-3615

M3 - Article

SP - clincanres.3615.2017

JO - Clinical Cancer Research

JF - Clinical Cancer Research

SN - 1078-0432

ER -