Identification of left ventricular volume regulation on the basis of the elastance concept

Peter L M Kerkhof; John K J Li

Identification of left ventricular volume regulation on the basis of the elastance concept

Peter L M Kerkhof^*, John K J Li

^*Corresponding author for this work

Radiology and nuclear medicine

Research output: Contribution to conference › Paper › Academic

Abstract

Left ventricular interaction with arterial load has been described in terms of the ratio (k) of effective arterial elastance (Ea) and maximal systolic elastance (Emax). Using the definition formulas for both elastances, a linear relationship between end-systolic volume (ESV) and end-diastolic volume (EDV) can be derived. The slope of this linearity equals k/(k+1), while the intercept can be identified as Vo/(k+1) where Vo is the extrapolated volume intercept of the linearized Emax-concept. Since the ESV vs EDV relationship refers to ventricular volume regulation, we have demonstrated that its characteristics can be exclusively expressed in terms of the coupling index k and the intercept Vo. We conclude that k and Vo are important determinants of the regulation of ventricular volume.

Original language	English
Pages	1213-1214
Number of pages	2
Publication status	Published - 1 Dec 2002
Event	Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States Duration: 23 Oct 2002 → 26 Oct 2002

Conference

Conference	Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS)
Country	United States
City	Houston, TX
Period	23/10/2002 → 26/10/2002

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title = "Identification of left ventricular volume regulation on the basis of the elastance concept",

abstract = "Left ventricular interaction with arterial load has been described in terms of the ratio (k) of effective arterial elastance (Ea) and maximal systolic elastance (Emax). Using the definition formulas for both elastances, a linear relationship between end-systolic volume (ESV) and end-diastolic volume (EDV) can be derived. The slope of this linearity equals k/(k+1), while the intercept can be identified as Vo/(k+1) where Vo is the extrapolated volume intercept of the linearized Emax-concept. Since the ESV vs EDV relationship refers to ventricular volume regulation, we have demonstrated that its characteristics can be exclusively expressed in terms of the coupling index k and the intercept Vo. We conclude that k and Vo are important determinants of the regulation of ventricular volume.",

author = "Kerkhof, {Peter L M} and Li, {John K J}",

year = "2002",

month = dec,

day = "1",

language = "English",

pages = "1213--1214",

note = "Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) ; Conference date: 23-10-2002 Through 26-10-2002",

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Kerkhof, PLM & Li, JKJ 2002, 'Identification of left ventricular volume regulation on the basis of the elastance concept', Paper presented at Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS), Houston, TX, United States, 23/10/2002 - 26/10/2002 pp. 1213-1214.

Identification of left ventricular volume regulation on the basis of the elastance concept. / Kerkhof, Peter L M; Li, John K J.

2002. 1213-1214 Paper presented at Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS), Houston, TX, United States.

Research output: Contribution to conference › Paper › Academic

TY - CONF

T1 - Identification of left ventricular volume regulation on the basis of the elastance concept

AU - Kerkhof, Peter L M

AU - Li, John K J

PY - 2002/12/1

Y1 - 2002/12/1

N2 - Left ventricular interaction with arterial load has been described in terms of the ratio (k) of effective arterial elastance (Ea) and maximal systolic elastance (Emax). Using the definition formulas for both elastances, a linear relationship between end-systolic volume (ESV) and end-diastolic volume (EDV) can be derived. The slope of this linearity equals k/(k+1), while the intercept can be identified as Vo/(k+1) where Vo is the extrapolated volume intercept of the linearized Emax-concept. Since the ESV vs EDV relationship refers to ventricular volume regulation, we have demonstrated that its characteristics can be exclusively expressed in terms of the coupling index k and the intercept Vo. We conclude that k and Vo are important determinants of the regulation of ventricular volume.

AB - Left ventricular interaction with arterial load has been described in terms of the ratio (k) of effective arterial elastance (Ea) and maximal systolic elastance (Emax). Using the definition formulas for both elastances, a linear relationship between end-systolic volume (ESV) and end-diastolic volume (EDV) can be derived. The slope of this linearity equals k/(k+1), while the intercept can be identified as Vo/(k+1) where Vo is the extrapolated volume intercept of the linearized Emax-concept. Since the ESV vs EDV relationship refers to ventricular volume regulation, we have demonstrated that its characteristics can be exclusively expressed in terms of the coupling index k and the intercept Vo. We conclude that k and Vo are important determinants of the regulation of ventricular volume.

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T2 - Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS)

Y2 - 23 October 2002 through 26 October 2002

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