TY - JOUR
T1 - Imaging strategies in the management of gastric cancer: Current role and future potential of MRI
AU - Borggreve, Alicia S.
AU - Goense, Lucas
AU - Brenkman, Hylke J. F.
AU - Mook, Stella
AU - Meijer, Gert J.
AU - Wessels, Frank J.
AU - Verheij, Marcel
AU - Jansen, Edwin P. M.
AU - van Hillegersberg, Richard
AU - van Rossum, Peter S. N.
AU - Ruurda, Jelle P.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Accurate preoperative staging of gastric cancer and the assessment of tumor response to neoadjuvant treatment is of importance for treatment and prognosis. Current imaging techniques, mainly endoscopic ultrasonography (EUS), computed tomography (CT) and 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET), have their limitations. Historically, the role of magnetic resonance imaging (MRI) in gastric cancer has been limited, but with the continuous technical improvements, MRI has become a more potent imaging technique for gastrointestinal malignancies. The accuracy of MRI for T- and N-staging of gastric cancer is similar to EUS and CT, making MRI a suitable alternative to other imaging strategies. There is limited evidence on the performance of MRI for M-staging of gastric cancer specifically, but MRI is widely used for diagnosing liver metastases and shows potential for diagnosing peritoneal seeding. Recent pilot studies showed that treatment response assessment as well as detection of lymph node metastases and systemic disease might benefit from functional MRI (e.g. diffusion weighted imaging and dynamic contrast enhancement). Regarding treatment guidance, additional value of MRI might be expected from its role in better defining clinical target volumes and setup verification with MR-guided radiation treatment.
AB - Accurate preoperative staging of gastric cancer and the assessment of tumor response to neoadjuvant treatment is of importance for treatment and prognosis. Current imaging techniques, mainly endoscopic ultrasonography (EUS), computed tomography (CT) and 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET), have their limitations. Historically, the role of magnetic resonance imaging (MRI) in gastric cancer has been limited, but with the continuous technical improvements, MRI has become a more potent imaging technique for gastrointestinal malignancies. The accuracy of MRI for T- and N-staging of gastric cancer is similar to EUS and CT, making MRI a suitable alternative to other imaging strategies. There is limited evidence on the performance of MRI for M-staging of gastric cancer specifically, but MRI is widely used for diagnosing liver metastases and shows potential for diagnosing peritoneal seeding. Recent pilot studies showed that treatment response assessment as well as detection of lymph node metastases and systemic disease might benefit from functional MRI (e.g. diffusion weighted imaging and dynamic contrast enhancement). Regarding treatment guidance, additional value of MRI might be expected from its role in better defining clinical target volumes and setup verification with MR-guided radiation treatment.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85064975228&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30789792
U2 - 10.1259/bjr.20181044
DO - 10.1259/bjr.20181044
M3 - Review article
C2 - 30789792
VL - 92
JO - British Journal of Radiology
JF - British Journal of Radiology
SN - 0007-1285
IS - 1097
M1 - 20181044
ER -