Immune checkpoint therapy: Tumor draining lymph nodes in the spotlights

Marieke F. Fransen*, Thorbald van Hall, Ferry Ossendorp

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review


Tumor‐draining lymph nodes play a paradoxical role in cancer. Surgeons often resect these sentinel lymph nodes to determine metastatic spread, thereby enabling prognosis and treat-ment. However, lymph nodes are vital organs for the orchestration of immune responses, due to the close encounters of dedicated immune cells. In view of the success of immunotherapy, the removal of tumor‐draining lymph nodes needs to be re‐evaluated and viewed in a different light. Recently, an important role for tumor‐draining lymph nodes has been proposed in the immunotherapy of cancer. This new insight can change the use of immune checkpoint therapy, particularly with re-spect to the use in neoadjuvant settings in which lymph nodes are still operational.
Original languageEnglish
Article number9401
JournalInternational Journal of Molecular Sciences
Issue number17
Publication statusPublished - 1 Sep 2021

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