Immune dysfunction in HIV-seronegative, Cryptococcus gattii meningitis

Annemarie E. Brouwer, Asna A. Siddiqui, Maartje I. Kester, Kim C.E. Sigaloff, Adul Rajanuwong, Saran Wannapasni, Wirongrong Chierakul, Thomas S. Harrison*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


The pathophysiology of meningitis caused by Cryptococcus gattii in apparently immunocompetent individuals remains unclear. We measured multiple cytokines in CSF from a HIV-seronegative, apparently immunocompetent, Thai patient with C. gattii meningitis, over the first 2 weeks of antifungal therapy. Levels of proinflammatory IFN-γ, TNF-α, and IL-6 were very low compared to patients with HIV-related Cryptococcus neoformans meningitis and of IL-10 very high. While patients with C. gattii meningitis may be a heterogeneous group, these data suggest in this case a maladapted immune response to cryptococcal exposure had allowed progression to clinical cryptococcal disease.

Original languageEnglish
JournalJournal of Infection
Issue number3
Publication statusPublished - 1 Mar 2007

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