Immune escape through C-type lectins on dendritic cells

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Dendritic cells (DCs) detect different pathogens and elicit tailored anti-microbial immune responses. They express C-type lectins that recognise carbohydrate profiles on microorganisms, resulting in internalisation, processing and presentation. Intracellular sequences of distinct DC-specific lectins point to differences in intracellular routing that influence antigen presentation. Moreover, putative signalling motifs hint to the activation of DCs on carbohydrate recognition. Recent evidence shows that not only pathogens, but also tumour antigens, exploit C-type lectins to escape intracellular degradation resulting in abortive immunity. More insight into ligand specificity, intracellular targeting and signalling will reveal the pathways by which pathogens modulate immunity through C-type lectins.

Original languageEnglish
Pages (from-to)480-5
Number of pages6
JournalTrends in Immunology
Volume23
Issue number10
Publication statusPublished - Oct 2002

Cite this

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title = "Immune escape through C-type lectins on dendritic cells",
abstract = "Dendritic cells (DCs) detect different pathogens and elicit tailored anti-microbial immune responses. They express C-type lectins that recognise carbohydrate profiles on microorganisms, resulting in internalisation, processing and presentation. Intracellular sequences of distinct DC-specific lectins point to differences in intracellular routing that influence antigen presentation. Moreover, putative signalling motifs hint to the activation of DCs on carbohydrate recognition. Recent evidence shows that not only pathogens, but also tumour antigens, exploit C-type lectins to escape intracellular degradation resulting in abortive immunity. More insight into ligand specificity, intracellular targeting and signalling will reveal the pathways by which pathogens modulate immunity through C-type lectins.",
keywords = "Animals, Antigen Presentation, Carbohydrates/immunology, Dendritic Cells/immunology, HIV Infections/immunology, Humans, Immunity, Cellular, Lectins/classification, Ligands, Neoplasms/immunology",
author = "Anneke Engering and Geijtenbeek, {Teunis B H} and {van Kooyk}, Yvette",
year = "2002",
month = "10",
language = "English",
volume = "23",
pages = "480--5",
journal = "Trends in Immunology",
issn = "1471-4906",
publisher = "Elsevier Limited",
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Immune escape through C-type lectins on dendritic cells. / Engering, Anneke; Geijtenbeek, Teunis B H; van Kooyk, Yvette.

In: Trends in Immunology, Vol. 23, No. 10, 10.2002, p. 480-5.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Immune escape through C-type lectins on dendritic cells

AU - Engering, Anneke

AU - Geijtenbeek, Teunis B H

AU - van Kooyk, Yvette

PY - 2002/10

Y1 - 2002/10

N2 - Dendritic cells (DCs) detect different pathogens and elicit tailored anti-microbial immune responses. They express C-type lectins that recognise carbohydrate profiles on microorganisms, resulting in internalisation, processing and presentation. Intracellular sequences of distinct DC-specific lectins point to differences in intracellular routing that influence antigen presentation. Moreover, putative signalling motifs hint to the activation of DCs on carbohydrate recognition. Recent evidence shows that not only pathogens, but also tumour antigens, exploit C-type lectins to escape intracellular degradation resulting in abortive immunity. More insight into ligand specificity, intracellular targeting and signalling will reveal the pathways by which pathogens modulate immunity through C-type lectins.

AB - Dendritic cells (DCs) detect different pathogens and elicit tailored anti-microbial immune responses. They express C-type lectins that recognise carbohydrate profiles on microorganisms, resulting in internalisation, processing and presentation. Intracellular sequences of distinct DC-specific lectins point to differences in intracellular routing that influence antigen presentation. Moreover, putative signalling motifs hint to the activation of DCs on carbohydrate recognition. Recent evidence shows that not only pathogens, but also tumour antigens, exploit C-type lectins to escape intracellular degradation resulting in abortive immunity. More insight into ligand specificity, intracellular targeting and signalling will reveal the pathways by which pathogens modulate immunity through C-type lectins.

KW - Animals

KW - Antigen Presentation

KW - Carbohydrates/immunology

KW - Dendritic Cells/immunology

KW - HIV Infections/immunology

KW - Humans

KW - Immunity, Cellular

KW - Lectins/classification

KW - Ligands

KW - Neoplasms/immunology

M3 - Review article

VL - 23

SP - 480

EP - 485

JO - Trends in Immunology

JF - Trends in Immunology

SN - 1471-4906

IS - 10

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