Impact of Bone Volume Upon Condylar Activity in Patients With Unilateral Condylar Hyperplasia

Luc H E Karssemakers, Jitske W Nolte, D Bram Tuinzing, Geerling E J Langenbach, Alfred G Becking, Pieter G Raijmakers

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

PURPOSE: Unilateral condylar hyperplasia or hyperactivity (UCH) is a bone overgrowth disorder affecting the mandible. The purpose of this study was to determine the relations among age, condylar bone structure, condylar bone volume, and condylar bone activity on single-photon emission computed tomographic (SPECT) scans in patients with UCH.

MATERIALS AND METHODS: This study included 20 patients with a clinical presentation of progressive mandibular asymmetry and a positive bone SPECT scan. A bone SPECT-derived standardized uptake value (bSUV) for the condylar region was determined. All patients underwent condylectomy to arrest further progression of the disease. The resected condyles were scanned with a micro-computed tomographic scanner (18-μm resolution). Bone architectural parameters were calculated with routine morphometric software.

RESULTS: The mean bSUV of the condyle on the affected side was 15.32 (standard deviation [SD], 8.98) compared with 9.85 (SD, 4.40) on the nonaffected side (P = .0007). For trabecular bone structure, there was a nonsignificant correlation between the SUV of the affected condyle and the measured bone volume fraction (r = 0.13; P = .58) and trabecular thickness (r = 0.03; P = .90).

CONCLUSION: No meaningful relation was found between condylar bone volume fraction and condylar activity on bone scan; therefore, the impact of bone volume fraction on the results of bone scans is limited. The measured condylar activity on SPECT scan seems to be primarily a reflection of the remodeling rate of bone.

Original languageEnglish
Pages (from-to)2177-2182
Number of pages6
JournalJournal of Oral and Maxillofacial Surgery
Volume76
Issue number10
DOIs
Publication statusPublished - Oct 2018

Cite this

@article{cf9cfac91f5d4696b67a6908ba8348d3,
title = "Impact of Bone Volume Upon Condylar Activity in Patients With Unilateral Condylar Hyperplasia",
abstract = "PURPOSE: Unilateral condylar hyperplasia or hyperactivity (UCH) is a bone overgrowth disorder affecting the mandible. The purpose of this study was to determine the relations among age, condylar bone structure, condylar bone volume, and condylar bone activity on single-photon emission computed tomographic (SPECT) scans in patients with UCH.MATERIALS AND METHODS: This study included 20 patients with a clinical presentation of progressive mandibular asymmetry and a positive bone SPECT scan. A bone SPECT-derived standardized uptake value (bSUV) for the condylar region was determined. All patients underwent condylectomy to arrest further progression of the disease. The resected condyles were scanned with a micro-computed tomographic scanner (18-μm resolution). Bone architectural parameters were calculated with routine morphometric software.RESULTS: The mean bSUV of the condyle on the affected side was 15.32 (standard deviation [SD], 8.98) compared with 9.85 (SD, 4.40) on the nonaffected side (P = .0007). For trabecular bone structure, there was a nonsignificant correlation between the SUV of the affected condyle and the measured bone volume fraction (r = 0.13; P = .58) and trabecular thickness (r = 0.03; P = .90).CONCLUSION: No meaningful relation was found between condylar bone volume fraction and condylar activity on bone scan; therefore, the impact of bone volume fraction on the results of bone scans is limited. The measured condylar activity on SPECT scan seems to be primarily a reflection of the remodeling rate of bone.",
keywords = "hyperplasia, mandibular, Growth, bone metabolism, micro CT, SPECT, Technetium, Hyperplasia/diagnostic imaging, Maxillofacial, Asymmetry, Facial Asymmetry/etiology, Facial Bones/diagnostic imaging, Bone architecture, Trabecular bone, Bone seeking radiopharmaceutical, Bone, Mandibular Condyle/diagnostic imaging, mandible, Quantification",
author = "Karssemakers, {Luc H E} and Nolte, {Jitske W} and Tuinzing, {D Bram} and Langenbach, {Geerling E J} and Becking, {Alfred G} and Raijmakers, {Pieter G}",
note = "Copyright {\circledC} 2018 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.",
year = "2018",
month = "10",
doi = "10.1016/j.joms.2018.03.023",
language = "English",
volume = "76",
pages = "2177--2182",
journal = "Journal of Oral and Maxillofacial Surgery",
issn = "0278-2391",
publisher = "W.B. Saunders Ltd",
number = "10",

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Impact of Bone Volume Upon Condylar Activity in Patients With Unilateral Condylar Hyperplasia. / Karssemakers, Luc H E; Nolte, Jitske W; Tuinzing, D Bram; Langenbach, Geerling E J; Becking, Alfred G; Raijmakers, Pieter G.

In: Journal of Oral and Maxillofacial Surgery, Vol. 76, No. 10, 10.2018, p. 2177-2182.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Impact of Bone Volume Upon Condylar Activity in Patients With Unilateral Condylar Hyperplasia

AU - Karssemakers, Luc H E

AU - Nolte, Jitske W

AU - Tuinzing, D Bram

AU - Langenbach, Geerling E J

AU - Becking, Alfred G

AU - Raijmakers, Pieter G

N1 - Copyright © 2018 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

PY - 2018/10

Y1 - 2018/10

N2 - PURPOSE: Unilateral condylar hyperplasia or hyperactivity (UCH) is a bone overgrowth disorder affecting the mandible. The purpose of this study was to determine the relations among age, condylar bone structure, condylar bone volume, and condylar bone activity on single-photon emission computed tomographic (SPECT) scans in patients with UCH.MATERIALS AND METHODS: This study included 20 patients with a clinical presentation of progressive mandibular asymmetry and a positive bone SPECT scan. A bone SPECT-derived standardized uptake value (bSUV) for the condylar region was determined. All patients underwent condylectomy to arrest further progression of the disease. The resected condyles were scanned with a micro-computed tomographic scanner (18-μm resolution). Bone architectural parameters were calculated with routine morphometric software.RESULTS: The mean bSUV of the condyle on the affected side was 15.32 (standard deviation [SD], 8.98) compared with 9.85 (SD, 4.40) on the nonaffected side (P = .0007). For trabecular bone structure, there was a nonsignificant correlation between the SUV of the affected condyle and the measured bone volume fraction (r = 0.13; P = .58) and trabecular thickness (r = 0.03; P = .90).CONCLUSION: No meaningful relation was found between condylar bone volume fraction and condylar activity on bone scan; therefore, the impact of bone volume fraction on the results of bone scans is limited. The measured condylar activity on SPECT scan seems to be primarily a reflection of the remodeling rate of bone.

AB - PURPOSE: Unilateral condylar hyperplasia or hyperactivity (UCH) is a bone overgrowth disorder affecting the mandible. The purpose of this study was to determine the relations among age, condylar bone structure, condylar bone volume, and condylar bone activity on single-photon emission computed tomographic (SPECT) scans in patients with UCH.MATERIALS AND METHODS: This study included 20 patients with a clinical presentation of progressive mandibular asymmetry and a positive bone SPECT scan. A bone SPECT-derived standardized uptake value (bSUV) for the condylar region was determined. All patients underwent condylectomy to arrest further progression of the disease. The resected condyles were scanned with a micro-computed tomographic scanner (18-μm resolution). Bone architectural parameters were calculated with routine morphometric software.RESULTS: The mean bSUV of the condyle on the affected side was 15.32 (standard deviation [SD], 8.98) compared with 9.85 (SD, 4.40) on the nonaffected side (P = .0007). For trabecular bone structure, there was a nonsignificant correlation between the SUV of the affected condyle and the measured bone volume fraction (r = 0.13; P = .58) and trabecular thickness (r = 0.03; P = .90).CONCLUSION: No meaningful relation was found between condylar bone volume fraction and condylar activity on bone scan; therefore, the impact of bone volume fraction on the results of bone scans is limited. The measured condylar activity on SPECT scan seems to be primarily a reflection of the remodeling rate of bone.

KW - hyperplasia

KW - mandibular

KW - Growth

KW - bone metabolism

KW - micro CT

KW - SPECT

KW - Technetium

KW - Hyperplasia/diagnostic imaging

KW - Maxillofacial

KW - Asymmetry

KW - Facial Asymmetry/etiology

KW - Facial Bones/diagnostic imaging

KW - Bone architecture

KW - Trabecular bone

KW - Bone seeking radiopharmaceutical

KW - Bone

KW - Mandibular Condyle/diagnostic imaging

KW - mandible

KW - Quantification

U2 - 10.1016/j.joms.2018.03.023

DO - 10.1016/j.joms.2018.03.023

M3 - Article

VL - 76

SP - 2177

EP - 2182

JO - Journal of Oral and Maxillofacial Surgery

JF - Journal of Oral and Maxillofacial Surgery

SN - 0278-2391

IS - 10

ER -