Impact of open and minimally invasive resection of symptomatic solid benign liver tumours on symptoms and quality of life: a systematic review

Belle V. van Rosmalen, Jan Jaap de Graeff, Marcel J. van der Poel, Ilja E. de Man, Marc Besselink, Mohammad Abu Hilal, Olivier R. Busch, Joanne Verheij, Thomas M. van Gulik, Dutch Benign Liver Tumour Group

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Background: The value of open and minimally invasive liver resection for symptomatic solid benign liver tumours (BLT) such as hepatocellular adenoma, focal nodular hyperplasia and haemangioma is being debated. A systematic review on symptom relief, quality of life (QoL) and surgical outcome after both open and minimally invasive surgery for solid BLT is currently lacking. Methods: A systematic search in PubMed and EMBASE was performed according to the PRISMA guidelines (January 1985–April 2018). Articles reporting pre-and postoperative symptoms or QoL in patients undergoing open or minimally surgery for BLT were evaluated. Methodological quality was assessed using the MINORS tool. Results: Forty-two studies were included with 4061 patients undergoing surgery for BLT, 3536 (87%) open and 525 (13%) laparoscopic resections. Randomized and propensity-matched studies were lacking. Symptoms were the indication for resection in 56% of the patients. After a weighted mean of 28.5 months follow-up after surgery, symptoms were relieved in 82% of symptomatic patients. Validated QoL tools were used in eight studies, of which two found significant better QoL scores following laparoscopic compared to open surgery. Discussion: Resection of symptomatic BLT seems safe and relieves symptoms in the vast majority of selected patients. Comparative studies are needed before more firm conclusions can be drawn.
Original languageEnglish
Pages (from-to)1119-1130
JournalHPB
Volume21
Issue number9
DOIs
Publication statusPublished - 1 Sep 2019
Externally publishedYes

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