TY - JOUR
T1 - Impact of opium dependency on clinical and neuropsychological indices of multiple sclerosis patients
AU - Ayoobi, Fatemeh
AU - Bidaki, Reza
AU - Shamsizadeh, Ali
AU - Moghadam-Ahmadi, Amir
AU - Amiri, Houshang
PY - 2019/12/1
Y1 - 2019/12/1
N2 - The aim of this study was to determine the effect of opium on clinical and neuropsychological parameters in multiple sclerosis (MS) patients with substance dependency. A cross-sectional study was conducted on MS patients in Rafsanjan, Iran. Forty opium-addict MS patients (10 males and 30 females) aged between 18 and 50 years were compared with 40 MS patients with no addiction. Word-Pair Learning, Mini-Mental State Examination (MMSE), Wisconsin Card-Sorting Test (WCST), Depression, Anxiety, Expanded Disability Status Scale (EDSS), Fatigue, and the Multiple Sclerosis Functional Composite (MSFC) were measured and compared in the two groups. The comparison of two groups showed a significant increase trait anxiety (P < 0.001), fatigue (P = 0.009) and significant decrease in the executive function (P = 0.003), MMSE (P = 0.003), and working memory (P < 0.001) in addicted MS. It indicates the better efficiency of processing in the non-addicted MS patients. The MSFC z-score also was significantly higher in the non-addicted group (P < 0.001). The opium addiction has a negative impact on the clinical and neuropsychological outcome in MS patients.
AB - The aim of this study was to determine the effect of opium on clinical and neuropsychological parameters in multiple sclerosis (MS) patients with substance dependency. A cross-sectional study was conducted on MS patients in Rafsanjan, Iran. Forty opium-addict MS patients (10 males and 30 females) aged between 18 and 50 years were compared with 40 MS patients with no addiction. Word-Pair Learning, Mini-Mental State Examination (MMSE), Wisconsin Card-Sorting Test (WCST), Depression, Anxiety, Expanded Disability Status Scale (EDSS), Fatigue, and the Multiple Sclerosis Functional Composite (MSFC) were measured and compared in the two groups. The comparison of two groups showed a significant increase trait anxiety (P < 0.001), fatigue (P = 0.009) and significant decrease in the executive function (P = 0.003), MMSE (P = 0.003), and working memory (P < 0.001) in addicted MS. It indicates the better efficiency of processing in the non-addicted MS patients. The MSFC z-score also was significantly higher in the non-addicted group (P < 0.001). The opium addiction has a negative impact on the clinical and neuropsychological outcome in MS patients.
KW - Addiction
KW - Cognition
KW - Multiple sclerosis
KW - Opium
KW - Substance dependency
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85068769030&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31264108
U2 - 10.1007/s10072-019-03971-8
DO - 10.1007/s10072-019-03971-8
M3 - Article
C2 - 31264108
VL - 40
SP - 2501
EP - 2507
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 12
ER -