TY - JOUR
T1 - Impact of prevalent and incident vertebral fractures on utility: results from a patient-based and a population-based sample
AU - van Schoor, N.
AU - Ewing, S.
AU - O’Neill, T.
AU - Lunt, M.
AU - Smit, J.
AU - Lips, P.
PY - 2007
Y1 - 2007
N2 - Data are scarce on the impact of vertebral fractures (VFX) on utility. The objective of this study was to assess the impact
of prevalent and incident VFX on utility in both a patient-based and population-based sample. Data from the Multiple Outcomes
of Raloxifene Evaluation (MORE) study (n = 550 for prevalent VFX and n = 174 for incident VFX) and the European Prospective Osteoporosis Study (EPOS) (n = 236) were used. Utility was assessed by the index score of the EQ-5D. In the MORE study, highly statistically significant
associations were found between utility and the presence of prevalent VFX (p < 0.001), number of prevalent VFX (p < 0.001), severity of prevalent VFX (p < 0.001), the combination of number and severity of prevalent VFX (p = 0.001) and location of prevalent VFX (p = 0.019). The mean utility was significantly lower among women who suffered an incident VFX (utility = 0.67) than among women
who did not (utility = 0.77) (p = 0.005), although utility loss was not significantly different between the two groups (p = 0.142). In EPOS, the combination of number and severity of incident VFX was significantly related to utility (p = 0.030). In conclusion, utility is lower among persons with prevalent and incident VFX, especially in a patient-based sample.
Utility loss was not significantly different between women without and with incident VFX.
AB - Data are scarce on the impact of vertebral fractures (VFX) on utility. The objective of this study was to assess the impact
of prevalent and incident VFX on utility in both a patient-based and population-based sample. Data from the Multiple Outcomes
of Raloxifene Evaluation (MORE) study (n = 550 for prevalent VFX and n = 174 for incident VFX) and the European Prospective Osteoporosis Study (EPOS) (n = 236) were used. Utility was assessed by the index score of the EQ-5D. In the MORE study, highly statistically significant
associations were found between utility and the presence of prevalent VFX (p < 0.001), number of prevalent VFX (p < 0.001), severity of prevalent VFX (p < 0.001), the combination of number and severity of prevalent VFX (p = 0.001) and location of prevalent VFX (p = 0.019). The mean utility was significantly lower among women who suffered an incident VFX (utility = 0.67) than among women
who did not (utility = 0.77) (p = 0.005), although utility loss was not significantly different between the two groups (p = 0.142). In EPOS, the combination of number and severity of incident VFX was significantly related to utility (p = 0.030). In conclusion, utility is lower among persons with prevalent and incident VFX, especially in a patient-based sample.
Utility loss was not significantly different between women without and with incident VFX.
M3 - Article
JO - Quality of Life Research
JF - Quality of Life Research
SN - 0962-9343
ER -