Abstract
| Original language | English |
|---|---|
| Article number | 100619 |
| Journal | New Microbes and New Infections |
| Volume | 33 |
| DOIs | |
| Publication status | Published - 2020 |
| Externally published | Yes |
Cite this
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Impact of Waddlia chondrophila infection on pregnancy in the mouse. / Baud, D.; Ammerdorffer, A.; Buffe, Y.; Vouga, M.; Greub, G.; Stojanov, M.
In: New Microbes and New Infections, Vol. 33, 100619, 2020.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Impact of Waddlia chondrophila infection on pregnancy in the mouse
AU - Baud, D.
AU - Ammerdorffer, A.
AU - Buffe, Y.
AU - Vouga, M.
AU - Greub, G.
AU - Stojanov, M.
PY - 2020
Y1 - 2020
N2 - The intracellular bacterium Waddlia chondrophila, which belongs to the Chlamydiales order, was found to be associated with miscarriage in humans. There is little to no knowledge regarding the mode of infection, impact on the neonate and pathophysiology of this emerging bacterium. We have previously shown that W. chondrophila induces a systemic infection, organ pathology and elicits T helper type 1-associated humoral immunity in a murine model of genital infection. In the present study, we took advantage of this model of infection to evaluate the impact of this bacterium on the mouse pregnancy. We used two routes of inoculation, vaginal and intrauterine, to introduce infection before and after mating. Our results show that genital infection by W. chondrophila did not have any significant impact on gestation length and maternal weight gain, nor on the number of offspring and their weight. This observation indicates that the mouse model of infection is not suitable to study the effect of W. chondrophila on pregnancy and alternative models of infection, including in vitro ones, should be used. Moreover, an indirect immunopathological mechanism activated by this bacterium should be further explored.
AB - The intracellular bacterium Waddlia chondrophila, which belongs to the Chlamydiales order, was found to be associated with miscarriage in humans. There is little to no knowledge regarding the mode of infection, impact on the neonate and pathophysiology of this emerging bacterium. We have previously shown that W. chondrophila induces a systemic infection, organ pathology and elicits T helper type 1-associated humoral immunity in a murine model of genital infection. In the present study, we took advantage of this model of infection to evaluate the impact of this bacterium on the mouse pregnancy. We used two routes of inoculation, vaginal and intrauterine, to introduce infection before and after mating. Our results show that genital infection by W. chondrophila did not have any significant impact on gestation length and maternal weight gain, nor on the number of offspring and their weight. This observation indicates that the mouse model of infection is not suitable to study the effect of W. chondrophila on pregnancy and alternative models of infection, including in vitro ones, should be used. Moreover, an indirect immunopathological mechanism activated by this bacterium should be further explored.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85076322004&origin=inward
U2 - 10.1016/j.nmni.2019.100619
DO - 10.1016/j.nmni.2019.100619
M3 - Article
VL - 33
JO - New Microbes and New Infections
JF - New Microbes and New Infections
SN - 2052-2975
M1 - 100619
ER -