TY - JOUR
T1 - Implantation of Cultured Thymic Fragments in Patients With Acquired Immunodeficiency Syndrome
AU - Danner, Sven A.
AU - Schuurman, Henk Jan
AU - Lange, Joep M.A.
AU - Meyling, Frits H.J.Gmelig
AU - Schellekens, Peter Th A.
AU - Huber, Jonne
AU - Kater, Louis
PY - 1986/6
Y1 - 1986/6
N2 - • Cultured thymic fragments were implanted in one patient with acquired immunodeficiency syndrome (AIDS)-related complex (ARC) and in eight AIDS patients with opportunistic infections (Ols, four patients), Kaposi’s sarcoma (KS, two patients), or both (two patients). Thereafter, objective clinical improvement was noted in one patient with 01, and a stable symptom-free condition was observed in the ARC patient and in two other patients with Ols. However, the ARC patient and two of the three patients with Ols developed infections three to six months after implantation. A fourth case of 01 and the patients with KS showed progression of the disease. Peripheral blood investigations for counts of total leukocytes, lymphocytes, and T-lymphocyte subsets as well as for lymphocyte stimulation with mitogens showed no changes interpretable as an improvement of the cellular immune deficiency status. We conclude that cultured thymic fragments have no distinct in vivo effect on the course of AIDS, except for a temporary clinical improvement or a period of stable condition in some patients with Ols.
AB - • Cultured thymic fragments were implanted in one patient with acquired immunodeficiency syndrome (AIDS)-related complex (ARC) and in eight AIDS patients with opportunistic infections (Ols, four patients), Kaposi’s sarcoma (KS, two patients), or both (two patients). Thereafter, objective clinical improvement was noted in one patient with 01, and a stable symptom-free condition was observed in the ARC patient and in two other patients with Ols. However, the ARC patient and two of the three patients with Ols developed infections three to six months after implantation. A fourth case of 01 and the patients with KS showed progression of the disease. Peripheral blood investigations for counts of total leukocytes, lymphocytes, and T-lymphocyte subsets as well as for lymphocyte stimulation with mitogens showed no changes interpretable as an improvement of the cellular immune deficiency status. We conclude that cultured thymic fragments have no distinct in vivo effect on the course of AIDS, except for a temporary clinical improvement or a period of stable condition in some patients with Ols.
UR - http://www.scopus.com/inward/record.url?scp=84941815593&partnerID=8YFLogxK
U2 - 10.1001/archinte.1986.00360180129021
DO - 10.1001/archinte.1986.00360180129021
M3 - Article
C2 - 2940985
AN - SCOPUS:84941815593
VL - 146
SP - 1133
EP - 1136
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
SN - 0003-9926
IS - 6
ER -