Implementation of subjective cognitive decline criteria in research studies

José L. Molinuevo, Laura A. Rabin, Rebecca Amariglio, Rachel Buckley, Bruno Dubois, Kathryn A. Ellis, Michael Ewers, Harald Hampel, Stefan Klöppel, Lorena Rami, Barry Reisberg, Andrew J. Saykin, Sietske Sikkes, Colette M. Smart, Beth E. Snitz, Reisa Sperling, Wiesje M. van der Flier, Michael Wagner, Frank Jessen

Research output: Contribution to journalShort surveyAcademicpeer-review

Abstract

Introduction Subjective cognitive decline (SCD) manifesting before clinical impairment could serve as a target population for early intervention trials in Alzheimer's disease (AD). A working group, the Subjective Cognitive Decline Initiative (SCD-I), published SCD research criteria in the context of preclinical AD. To successfully apply them, a number of issues regarding assessment and implementation of SCD needed to be addressed. Methods Members of the SCD-I met to identify and agree on topics relevant to SCD criteria operationalization in research settings. Initial ideas and recommendations were discussed with other SCD-I working group members and modified accordingly. Results Topics included SCD inclusion and exclusion criteria, together with the informant's role in defining SCD presence and the impact of demographic factors. Discussion Recommendations for the operationalization of SCD in differing research settings, with the aim of harmonization of SCD measurement across studies are proposed, to enhance comparability and generalizability across studies.

Original languageEnglish
Pages (from-to)296-311
Number of pages16
JournalAlzheimers & Dementia
Volume13
Issue number3
DOIs
Publication statusPublished - 1 Mar 2017

Cite this

Molinuevo, J. L., Rabin, L. A., Amariglio, R., Buckley, R., Dubois, B., Ellis, K. A., ... Jessen, F. (2017). Implementation of subjective cognitive decline criteria in research studies. Alzheimers & Dementia, 13(3), 296-311. https://doi.org/10.1016/j.jalz.2016.09.012
Molinuevo, José L. ; Rabin, Laura A. ; Amariglio, Rebecca ; Buckley, Rachel ; Dubois, Bruno ; Ellis, Kathryn A. ; Ewers, Michael ; Hampel, Harald ; Klöppel, Stefan ; Rami, Lorena ; Reisberg, Barry ; Saykin, Andrew J. ; Sikkes, Sietske ; Smart, Colette M. ; Snitz, Beth E. ; Sperling, Reisa ; van der Flier, Wiesje M. ; Wagner, Michael ; Jessen, Frank. / Implementation of subjective cognitive decline criteria in research studies. In: Alzheimers & Dementia. 2017 ; Vol. 13, No. 3. pp. 296-311.
@article{c14e7889cf0d4c11b348e208b74afb4f,
title = "Implementation of subjective cognitive decline criteria in research studies",
abstract = "Introduction Subjective cognitive decline (SCD) manifesting before clinical impairment could serve as a target population for early intervention trials in Alzheimer's disease (AD). A working group, the Subjective Cognitive Decline Initiative (SCD-I), published SCD research criteria in the context of preclinical AD. To successfully apply them, a number of issues regarding assessment and implementation of SCD needed to be addressed. Methods Members of the SCD-I met to identify and agree on topics relevant to SCD criteria operationalization in research settings. Initial ideas and recommendations were discussed with other SCD-I working group members and modified accordingly. Results Topics included SCD inclusion and exclusion criteria, together with the informant's role in defining SCD presence and the impact of demographic factors. Discussion Recommendations for the operationalization of SCD in differing research settings, with the aim of harmonization of SCD measurement across studies are proposed, to enhance comparability and generalizability across studies.",
keywords = "Alzheimer's disease, Harmonization, Operationalization, Preclinical, SCD-I, Subjective cognitive decline (SDC)",
author = "Molinuevo, {Jos{\'e} L.} and Rabin, {Laura A.} and Rebecca Amariglio and Rachel Buckley and Bruno Dubois and Ellis, {Kathryn A.} and Michael Ewers and Harald Hampel and Stefan Kl{\"o}ppel and Lorena Rami and Barry Reisberg and Saykin, {Andrew J.} and Sietske Sikkes and Smart, {Colette M.} and Snitz, {Beth E.} and Reisa Sperling and {van der Flier}, {Wiesje M.} and Michael Wagner and Frank Jessen",
year = "2017",
month = "3",
day = "1",
doi = "10.1016/j.jalz.2016.09.012",
language = "English",
volume = "13",
pages = "296--311",
journal = "Alzheimers & Dementia",
issn = "1552-5260",
publisher = "Elsevier",
number = "3",

}

Molinuevo, JL, Rabin, LA, Amariglio, R, Buckley, R, Dubois, B, Ellis, KA, Ewers, M, Hampel, H, Klöppel, S, Rami, L, Reisberg, B, Saykin, AJ, Sikkes, S, Smart, CM, Snitz, BE, Sperling, R, van der Flier, WM, Wagner, M & Jessen, F 2017, 'Implementation of subjective cognitive decline criteria in research studies' Alzheimers & Dementia, vol. 13, no. 3, pp. 296-311. https://doi.org/10.1016/j.jalz.2016.09.012

Implementation of subjective cognitive decline criteria in research studies. / Molinuevo, José L.; Rabin, Laura A.; Amariglio, Rebecca; Buckley, Rachel; Dubois, Bruno; Ellis, Kathryn A.; Ewers, Michael; Hampel, Harald; Klöppel, Stefan; Rami, Lorena; Reisberg, Barry; Saykin, Andrew J.; Sikkes, Sietske; Smart, Colette M.; Snitz, Beth E.; Sperling, Reisa; van der Flier, Wiesje M.; Wagner, Michael; Jessen, Frank.

In: Alzheimers & Dementia, Vol. 13, No. 3, 01.03.2017, p. 296-311.

Research output: Contribution to journalShort surveyAcademicpeer-review

TY - JOUR

T1 - Implementation of subjective cognitive decline criteria in research studies

AU - Molinuevo, José L.

AU - Rabin, Laura A.

AU - Amariglio, Rebecca

AU - Buckley, Rachel

AU - Dubois, Bruno

AU - Ellis, Kathryn A.

AU - Ewers, Michael

AU - Hampel, Harald

AU - Klöppel, Stefan

AU - Rami, Lorena

AU - Reisberg, Barry

AU - Saykin, Andrew J.

AU - Sikkes, Sietske

AU - Smart, Colette M.

AU - Snitz, Beth E.

AU - Sperling, Reisa

AU - van der Flier, Wiesje M.

AU - Wagner, Michael

AU - Jessen, Frank

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Introduction Subjective cognitive decline (SCD) manifesting before clinical impairment could serve as a target population for early intervention trials in Alzheimer's disease (AD). A working group, the Subjective Cognitive Decline Initiative (SCD-I), published SCD research criteria in the context of preclinical AD. To successfully apply them, a number of issues regarding assessment and implementation of SCD needed to be addressed. Methods Members of the SCD-I met to identify and agree on topics relevant to SCD criteria operationalization in research settings. Initial ideas and recommendations were discussed with other SCD-I working group members and modified accordingly. Results Topics included SCD inclusion and exclusion criteria, together with the informant's role in defining SCD presence and the impact of demographic factors. Discussion Recommendations for the operationalization of SCD in differing research settings, with the aim of harmonization of SCD measurement across studies are proposed, to enhance comparability and generalizability across studies.

AB - Introduction Subjective cognitive decline (SCD) manifesting before clinical impairment could serve as a target population for early intervention trials in Alzheimer's disease (AD). A working group, the Subjective Cognitive Decline Initiative (SCD-I), published SCD research criteria in the context of preclinical AD. To successfully apply them, a number of issues regarding assessment and implementation of SCD needed to be addressed. Methods Members of the SCD-I met to identify and agree on topics relevant to SCD criteria operationalization in research settings. Initial ideas and recommendations were discussed with other SCD-I working group members and modified accordingly. Results Topics included SCD inclusion and exclusion criteria, together with the informant's role in defining SCD presence and the impact of demographic factors. Discussion Recommendations for the operationalization of SCD in differing research settings, with the aim of harmonization of SCD measurement across studies are proposed, to enhance comparability and generalizability across studies.

KW - Alzheimer's disease

KW - Harmonization

KW - Operationalization

KW - Preclinical

KW - SCD-I

KW - Subjective cognitive decline (SDC)

UR - http://www.scopus.com/inward/record.url?scp=85006908624&partnerID=8YFLogxK

U2 - 10.1016/j.jalz.2016.09.012

DO - 10.1016/j.jalz.2016.09.012

M3 - Short survey

VL - 13

SP - 296

EP - 311

JO - Alzheimers & Dementia

JF - Alzheimers & Dementia

SN - 1552-5260

IS - 3

ER -

Molinuevo JL, Rabin LA, Amariglio R, Buckley R, Dubois B, Ellis KA et al. Implementation of subjective cognitive decline criteria in research studies. Alzheimers & Dementia. 2017 Mar 1;13(3):296-311. https://doi.org/10.1016/j.jalz.2016.09.012