Improving outcomes for donation after circulatory death kidney transplantation: Science of the times

Michèle J.C. de Kok, Alexander F.M. Schaapherder, Ian P.J. Alwayn, Frederike J. Bemelman, Jacqueline van de Wetering, Arjan D. van Zuilen, Maarten H.L. Christiaans, Marije C. Baas, Azam S. Nurmohamed, Stefan P. Berger, Esther Bastiaannet, Rutger J. Ploeg, Aiko P.J. de Vries, Jan H.N. Lindeman

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The use of kidneys donated after circulatory death (DCD) remains controversial due to concerns with regard to high incidences of early graft loss, delayed graft function (DGF), and impaired graft survival. As these concerns are mainly based on data from historical cohorts, they are prone to time-related effects and may therefore not apply to the current timeframe. To assess the impact of time on outcomes, we performed a time-dependent comparative analysis of outcomes of DCD and donation after brain death (DBD) kidney transplantations. Data of all 11,415 deceased-donor kidney transplantations performed in The Netherlands between 1990-2018 were collected. Based on the incidences of early graft loss, two eras were defined (1998-2008 [n = 3,499] and 2008-2018 [n = 3,781]), and potential time-related effects on outcomes evaluated. Multivariate analyses were applied to examine associations between donor type and outcomes. Interaction tests were used to explore presence of effect modification. Results show clear time-related effects on posttransplant outcomes. The 1998-2008 interval showed compromised outcomes for DCD procedures (higher incidences of DGF and early graft loss, impaired 1-year renal function, and inferior graft survival), whereas DBD and DCD outcome equivalence was observed for the 2008-2018 interval. This occurred despite persistently high incidences of DGF in DCD grafts, and more adverse recipient and donor risk profiles (recipients were 6 years older and the KDRI increased from 1.23 to 1.39 and from 1.35 to 1.49 for DBD and DCD donors). In contrast, the median cold ischaemic period decreased from 20 to 15 hours. This national study shows major improvements in outcomes of transplanted DCD kidneys over time. The time-dependent shift underpins that kidney transplantation has come of age and DCD results are nowadays comparable to DBD transplants. It also calls for careful interpretation of conclusions based on historical cohorts, and emphasises that retrospective studies should correct for time-related effects.

Original languageEnglish
Article numbere0236662
Pages (from-to)e0236662
JournalPLoS ONE
Volume15
Issue number7
DOIs
Publication statusPublished - 1 Jan 2020

Cite this

de Kok, M. J. C., Schaapherder, A. F. M., Alwayn, I. P. J., Bemelman, F. J., van de Wetering, J., van Zuilen, A. D., ... Lindeman, J. H. N. (2020). Improving outcomes for donation after circulatory death kidney transplantation: Science of the times. PLoS ONE, 15(7), e0236662. [e0236662]. https://doi.org/10.1371/journal.pone.0236662