In vitro studies on gemcitabine combinations with other antiblastics

E. Giovannetti, R. Danesi*, V. Mey, S. Nannizzi, G. Pasqualetti, M. Del Tacca

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The use of gemcitabine in combination with chemotherapeutic agents, including cisplatin, pemetrexed and taxanes, is characterized by the enhancement of their anticancer activity. The analysis of the underlying pharmacodynamics has revealed that modulation of nucleotide pools, drug metabolism, and cellular DNA repair capability are the most common factors to explain the additive to synergistic interaction between gemcitabine and anticancer agents in several human cancers in vitro and in vivo.

Original languageEnglish
JournalAnnals of Oncology
Volume17
Issue numberSUPPL. 5
DOIs
Publication statusPublished - 1 May 2006

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