In vivo measurement of [11C]verapamil kinetics in human tissues

N. H. Hendrikse*, E. G.E. De Vries, E. J.F. Franssen, W. Vaalburg, W. T.A. Van Der Graaf

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objectiva: To evaluate [11C]verapamil kinetics in humans. Methods: After intravenous injection of [11C]verapamil (370 MBq, specific activity >1600 GBq/mmol), kinetics were evaluated in five cancer patients using positron emission tomography (PET). Results: One hour after injection, accumulation of [11C] in lungs, heart and tumour was 43.0%, 1.3% and 0.9% of the injected verapamil dose, respectively. Half-lives of [11C]verapamil in these tissues were 46.2 min, 73.8 min and 23.7 min, respectively. Conclusions: Intravenously administered [11C] was mainly extracted by the lungs. Transport of a [11C]verapamil bolus out of solid tumour tissue is relatively fast.

Original languageEnglish
Pages (from-to)827-829
Number of pages3
JournalEuropean Journal of Clinical Pharmacology
Volume56
Issue number11
DOIs
Publication statusPublished - 1 Dec 2001

Cite this

Hendrikse, N. H., De Vries, E. G. E., Franssen, E. J. F., Vaalburg, W., & Van Der Graaf, W. T. A. (2001). In vivo measurement of [11C]verapamil kinetics in human tissues. European Journal of Clinical Pharmacology, 56(11), 827-829. https://doi.org/10.1007/s002280000253