In Vivo Validation of Magnetic Resonance Blood Volume Flow Measurements with Limited Spatial Resolution in Small Vessels

Mark B.M. Hofman, Frans C. Visser, Albert C. Van Rossum, Ger Q.M. Vink, Michiel Sprenger, Nico Westerhof

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The accuracy of magnetic resonance phase contrast volume flow measurements in small blood vessels is expected to be smaller than in large vessels, because of partial volume effects at the vessel boundary. Accuracy was validated in the dog femoral artery, diameter 3.5 ± 0.7 mm, using an ultrasonic transit‐time flowmeter (TT). The number of pixels per vessel diameter (ND) ranged from 1.6 to 4.8. The vessel cross‐section was determined using a threshold in the magnitude image. Between the two methods the correlation coefficient was 0.95 (range 10–200 ml/min). The proportional difference (PD), (QTT – QMR/1/2(QTT + QMR), was 0.8%, showing no systematic difference between the methods. The PDs standard deviation was 27%, and 19% for flow rates above 30 ml/min. Only a significant decrease of the PDs variance was found at the highest ND values, suggesting other sources of error than partial volume effects. It is concluded that with an ND value of about 3, accurate blood volume flow rates can be determined.

Original languageEnglish
Pages (from-to)778-784
Number of pages7
JournalMagnetic Resonance in Medicine
Volume33
Issue number6
DOIs
Publication statusPublished - 1 Jan 1995

Cite this

@article{0dccfff0a425404992cb7f22b3b36630,
title = "In Vivo Validation of Magnetic Resonance Blood Volume Flow Measurements with Limited Spatial Resolution in Small Vessels",
abstract = "The accuracy of magnetic resonance phase contrast volume flow measurements in small blood vessels is expected to be smaller than in large vessels, because of partial volume effects at the vessel boundary. Accuracy was validated in the dog femoral artery, diameter 3.5 ± 0.7 mm, using an ultrasonic transit‐time flowmeter (TT). The number of pixels per vessel diameter (ND) ranged from 1.6 to 4.8. The vessel cross‐section was determined using a threshold in the magnitude image. Between the two methods the correlation coefficient was 0.95 (range 10–200 ml/min). The proportional difference (PD), (QTT – QMR/1/2(QTT + QMR), was 0.8{\%}, showing no systematic difference between the methods. The PDs standard deviation was 27{\%}, and 19{\%} for flow rates above 30 ml/min. Only a significant decrease of the PDs variance was found at the highest ND values, suggesting other sources of error than partial volume effects. It is concluded that with an ND value of about 3, accurate blood volume flow rates can be determined.",
keywords = "accuracy, flow quantification, MRI, volume flow",
author = "Hofman, {Mark B.M.} and Visser, {Frans C.} and {Van Rossum}, {Albert C.} and Vink, {Ger Q.M.} and Michiel Sprenger and Nico Westerhof",
year = "1995",
month = "1",
day = "1",
doi = "10.1002/mrm.1910330606",
language = "English",
volume = "33",
pages = "778--784",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

In Vivo Validation of Magnetic Resonance Blood Volume Flow Measurements with Limited Spatial Resolution in Small Vessels. / Hofman, Mark B.M.; Visser, Frans C.; Van Rossum, Albert C.; Vink, Ger Q.M.; Sprenger, Michiel; Westerhof, Nico.

In: Magnetic Resonance in Medicine, Vol. 33, No. 6, 01.01.1995, p. 778-784.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - In Vivo Validation of Magnetic Resonance Blood Volume Flow Measurements with Limited Spatial Resolution in Small Vessels

AU - Hofman, Mark B.M.

AU - Visser, Frans C.

AU - Van Rossum, Albert C.

AU - Vink, Ger Q.M.

AU - Sprenger, Michiel

AU - Westerhof, Nico

PY - 1995/1/1

Y1 - 1995/1/1

N2 - The accuracy of magnetic resonance phase contrast volume flow measurements in small blood vessels is expected to be smaller than in large vessels, because of partial volume effects at the vessel boundary. Accuracy was validated in the dog femoral artery, diameter 3.5 ± 0.7 mm, using an ultrasonic transit‐time flowmeter (TT). The number of pixels per vessel diameter (ND) ranged from 1.6 to 4.8. The vessel cross‐section was determined using a threshold in the magnitude image. Between the two methods the correlation coefficient was 0.95 (range 10–200 ml/min). The proportional difference (PD), (QTT – QMR/1/2(QTT + QMR), was 0.8%, showing no systematic difference between the methods. The PDs standard deviation was 27%, and 19% for flow rates above 30 ml/min. Only a significant decrease of the PDs variance was found at the highest ND values, suggesting other sources of error than partial volume effects. It is concluded that with an ND value of about 3, accurate blood volume flow rates can be determined.

AB - The accuracy of magnetic resonance phase contrast volume flow measurements in small blood vessels is expected to be smaller than in large vessels, because of partial volume effects at the vessel boundary. Accuracy was validated in the dog femoral artery, diameter 3.5 ± 0.7 mm, using an ultrasonic transit‐time flowmeter (TT). The number of pixels per vessel diameter (ND) ranged from 1.6 to 4.8. The vessel cross‐section was determined using a threshold in the magnitude image. Between the two methods the correlation coefficient was 0.95 (range 10–200 ml/min). The proportional difference (PD), (QTT – QMR/1/2(QTT + QMR), was 0.8%, showing no systematic difference between the methods. The PDs standard deviation was 27%, and 19% for flow rates above 30 ml/min. Only a significant decrease of the PDs variance was found at the highest ND values, suggesting other sources of error than partial volume effects. It is concluded that with an ND value of about 3, accurate blood volume flow rates can be determined.

KW - accuracy

KW - flow quantification

KW - MRI

KW - volume flow

UR - http://www.scopus.com/inward/record.url?scp=0029000972&partnerID=8YFLogxK

U2 - 10.1002/mrm.1910330606

DO - 10.1002/mrm.1910330606

M3 - Article

VL - 33

SP - 778

EP - 784

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

IS - 6

ER -