Incidence of eosinophilic esophagitis in the Netherlands continues to rise: 20-year results from a nationwide pathology database

M. J. Warners, W. de Rooij, B. D. van Rhijn, J. Verheij, A. H. Bruggink, A. J. P. M. Smout, A. J. Bredenoord

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: The incidence of eosinophilic esophagitis (EoE) has increased rapidly. Most epidemiologic data were gathered in single-center studies over a short timeframe, possibly explaining the heterogeneous incidences. Aim: The aim of this study was to retrospectively estimate the Dutch nationwide incidence of EoE over the last 20 years. Methods: The Dutch pathology registry (PALGA) was queried to identify pathology reports describing esophageal eosinophilia from 1996 to 2016. Cases were eligible if EoE was confirmed by the pathologist. Using the annual Dutch population data, the incidence of EoE was calculated. Key Results: The search yielded 11 288 reports of which 5080 described esophageal eosinophilia. Eosinophilic esophagitis was diagnosed in 2161 patients, 1574 (73%) males and 365 (17%) children. The incidence increased from 0.01 (95% CI 0-0.02) in 1996 to 2.07 (95% CI 2.05-2.23) per 100 000 inhabitants in 2015. The incidence was higher in males than in females, 3.02 (95% CI 2.66-3.41) vs 1.14 (95% CI 0.93-1.38), odds ratio (OR) 2.66 (95% CI 2.10-3.36) and higher in adults than in children, 2.23 (95% CI 1.99-2.49) vs 1.46 (95% CI 1.09-1.91), OR 1.78 (95% CI 1.32-2.40). Incidence of EoE increased more than 200-fold, whereas endoscopy rates only tripled, from 30 in 1996 to 105 per 100 000 inhabitants in 2015. We observed no seasonal variation. Conclusions and Inferences: In the last decades, the Dutch EoE incidence has increased tremendously and still continues to rise. This expansion is only partially driven by increased endoscopy rates.
Original languageEnglish
Article numbere13165
JournalNeurogastroenterology and Motility
Volume30
Issue number1
DOIs
Publication statusPublished - 2018
Externally publishedYes

Cite this

Warners, M. J. ; de Rooij, W. ; van Rhijn, B. D. ; Verheij, J. ; Bruggink, A. H. ; Smout, A. J. P. M. ; Bredenoord, A. J. / Incidence of eosinophilic esophagitis in the Netherlands continues to rise: 20-year results from a nationwide pathology database. In: Neurogastroenterology and Motility. 2018 ; Vol. 30, No. 1.
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title = "Incidence of eosinophilic esophagitis in the Netherlands continues to rise: 20-year results from a nationwide pathology database",
abstract = "Background: The incidence of eosinophilic esophagitis (EoE) has increased rapidly. Most epidemiologic data were gathered in single-center studies over a short timeframe, possibly explaining the heterogeneous incidences. Aim: The aim of this study was to retrospectively estimate the Dutch nationwide incidence of EoE over the last 20 years. Methods: The Dutch pathology registry (PALGA) was queried to identify pathology reports describing esophageal eosinophilia from 1996 to 2016. Cases were eligible if EoE was confirmed by the pathologist. Using the annual Dutch population data, the incidence of EoE was calculated. Key Results: The search yielded 11 288 reports of which 5080 described esophageal eosinophilia. Eosinophilic esophagitis was diagnosed in 2161 patients, 1574 (73{\%}) males and 365 (17{\%}) children. The incidence increased from 0.01 (95{\%} CI 0-0.02) in 1996 to 2.07 (95{\%} CI 2.05-2.23) per 100 000 inhabitants in 2015. The incidence was higher in males than in females, 3.02 (95{\%} CI 2.66-3.41) vs 1.14 (95{\%} CI 0.93-1.38), odds ratio (OR) 2.66 (95{\%} CI 2.10-3.36) and higher in adults than in children, 2.23 (95{\%} CI 1.99-2.49) vs 1.46 (95{\%} CI 1.09-1.91), OR 1.78 (95{\%} CI 1.32-2.40). Incidence of EoE increased more than 200-fold, whereas endoscopy rates only tripled, from 30 in 1996 to 105 per 100 000 inhabitants in 2015. We observed no seasonal variation. Conclusions and Inferences: In the last decades, the Dutch EoE incidence has increased tremendously and still continues to rise. This expansion is only partially driven by increased endoscopy rates.",
author = "Warners, {M. J.} and {de Rooij}, W. and {van Rhijn}, {B. D.} and J. Verheij and Bruggink, {A. H.} and Smout, {A. J. P. M.} and Bredenoord, {A. J.}",
year = "2018",
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Incidence of eosinophilic esophagitis in the Netherlands continues to rise: 20-year results from a nationwide pathology database. / Warners, M. J.; de Rooij, W.; van Rhijn, B. D.; Verheij, J.; Bruggink, A. H.; Smout, A. J. P. M.; Bredenoord, A. J.

In: Neurogastroenterology and Motility, Vol. 30, No. 1, e13165, 2018.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Incidence of eosinophilic esophagitis in the Netherlands continues to rise: 20-year results from a nationwide pathology database

AU - Warners, M. J.

AU - de Rooij, W.

AU - van Rhijn, B. D.

AU - Verheij, J.

AU - Bruggink, A. H.

AU - Smout, A. J. P. M.

AU - Bredenoord, A. J.

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N2 - Background: The incidence of eosinophilic esophagitis (EoE) has increased rapidly. Most epidemiologic data were gathered in single-center studies over a short timeframe, possibly explaining the heterogeneous incidences. Aim: The aim of this study was to retrospectively estimate the Dutch nationwide incidence of EoE over the last 20 years. Methods: The Dutch pathology registry (PALGA) was queried to identify pathology reports describing esophageal eosinophilia from 1996 to 2016. Cases were eligible if EoE was confirmed by the pathologist. Using the annual Dutch population data, the incidence of EoE was calculated. Key Results: The search yielded 11 288 reports of which 5080 described esophageal eosinophilia. Eosinophilic esophagitis was diagnosed in 2161 patients, 1574 (73%) males and 365 (17%) children. The incidence increased from 0.01 (95% CI 0-0.02) in 1996 to 2.07 (95% CI 2.05-2.23) per 100 000 inhabitants in 2015. The incidence was higher in males than in females, 3.02 (95% CI 2.66-3.41) vs 1.14 (95% CI 0.93-1.38), odds ratio (OR) 2.66 (95% CI 2.10-3.36) and higher in adults than in children, 2.23 (95% CI 1.99-2.49) vs 1.46 (95% CI 1.09-1.91), OR 1.78 (95% CI 1.32-2.40). Incidence of EoE increased more than 200-fold, whereas endoscopy rates only tripled, from 30 in 1996 to 105 per 100 000 inhabitants in 2015. We observed no seasonal variation. Conclusions and Inferences: In the last decades, the Dutch EoE incidence has increased tremendously and still continues to rise. This expansion is only partially driven by increased endoscopy rates.

AB - Background: The incidence of eosinophilic esophagitis (EoE) has increased rapidly. Most epidemiologic data were gathered in single-center studies over a short timeframe, possibly explaining the heterogeneous incidences. Aim: The aim of this study was to retrospectively estimate the Dutch nationwide incidence of EoE over the last 20 years. Methods: The Dutch pathology registry (PALGA) was queried to identify pathology reports describing esophageal eosinophilia from 1996 to 2016. Cases were eligible if EoE was confirmed by the pathologist. Using the annual Dutch population data, the incidence of EoE was calculated. Key Results: The search yielded 11 288 reports of which 5080 described esophageal eosinophilia. Eosinophilic esophagitis was diagnosed in 2161 patients, 1574 (73%) males and 365 (17%) children. The incidence increased from 0.01 (95% CI 0-0.02) in 1996 to 2.07 (95% CI 2.05-2.23) per 100 000 inhabitants in 2015. The incidence was higher in males than in females, 3.02 (95% CI 2.66-3.41) vs 1.14 (95% CI 0.93-1.38), odds ratio (OR) 2.66 (95% CI 2.10-3.36) and higher in adults than in children, 2.23 (95% CI 1.99-2.49) vs 1.46 (95% CI 1.09-1.91), OR 1.78 (95% CI 1.32-2.40). Incidence of EoE increased more than 200-fold, whereas endoscopy rates only tripled, from 30 in 1996 to 105 per 100 000 inhabitants in 2015. We observed no seasonal variation. Conclusions and Inferences: In the last decades, the Dutch EoE incidence has increased tremendously and still continues to rise. This expansion is only partially driven by increased endoscopy rates.

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