Increase in daily LH secretion in response to short-term calorie restriction in obese women with PCOS

Eveline W C M Van Dam, Ferdinand Roelfsema, Johannes D. Veldhuis, Frans M. Helmerhorst, Marijke Frölich, A. Edo Meinders, H. Michiel J Krans, Hanno Pijl

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

We hypothesized that short-term calorie restriction would blunt luteinizing hormone (LH) hypersecretion in obese women with polycystic ovary syndrome (PCOS) and thereby ameliorate the anovulatory endocrine milieu. To test this hypothesis, 15 obese patients with PCOS and nine age- and body mass index-matched healthy women underwent 24-h blood sampling to quantitate plasma LH, leptin, and insulin levels. PCOS subjects were prescribed a very low caloric liquid diet (4.2 MJ/day) for 7 days and were then resampled. Basal and pulsatile LH secretion was threefold higher in PCOS subjects, but plasma insulin and leptin levels were not different in the calorie-replete state. Contrary to expectation, calorie restriction enhanced basal and pulsatile LH secretion even further. As expected, plasma glucose, insulin, and leptin concentrations decreased by 18, 75, and 50%, respectively. Serum total testosterone concentration fell by 23%, whereas serum estrone, estradiol, sex hormone-binding globulin (SHBG), and androstenedione concentrations remained unchanged. Enhanced LH secretion in the presence of normal metabolic and hormonal adaptations to calorie restriction points to anomalous feedback control of pituitary LH release in PCOS.

Original languageEnglish
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume282
Issue number4 45-4
Publication statusPublished - 29 Jun 2002

Cite this

Van Dam, E. W. C. M., Roelfsema, F., Veldhuis, J. D., Helmerhorst, F. M., Frölich, M., Edo Meinders, A., ... Pijl, H. (2002). Increase in daily LH secretion in response to short-term calorie restriction in obese women with PCOS. American Journal of Physiology - Endocrinology and Metabolism, 282(4 45-4).
Van Dam, Eveline W C M ; Roelfsema, Ferdinand ; Veldhuis, Johannes D. ; Helmerhorst, Frans M. ; Frölich, Marijke ; Edo Meinders, A. ; Krans, H. Michiel J ; Pijl, Hanno. / Increase in daily LH secretion in response to short-term calorie restriction in obese women with PCOS. In: American Journal of Physiology - Endocrinology and Metabolism. 2002 ; Vol. 282, No. 4 45-4.
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title = "Increase in daily LH secretion in response to short-term calorie restriction in obese women with PCOS",
abstract = "We hypothesized that short-term calorie restriction would blunt luteinizing hormone (LH) hypersecretion in obese women with polycystic ovary syndrome (PCOS) and thereby ameliorate the anovulatory endocrine milieu. To test this hypothesis, 15 obese patients with PCOS and nine age- and body mass index-matched healthy women underwent 24-h blood sampling to quantitate plasma LH, leptin, and insulin levels. PCOS subjects were prescribed a very low caloric liquid diet (4.2 MJ/day) for 7 days and were then resampled. Basal and pulsatile LH secretion was threefold higher in PCOS subjects, but plasma insulin and leptin levels were not different in the calorie-replete state. Contrary to expectation, calorie restriction enhanced basal and pulsatile LH secretion even further. As expected, plasma glucose, insulin, and leptin concentrations decreased by 18, 75, and 50{\%}, respectively. Serum total testosterone concentration fell by 23{\%}, whereas serum estrone, estradiol, sex hormone-binding globulin (SHBG), and androstenedione concentrations remained unchanged. Enhanced LH secretion in the presence of normal metabolic and hormonal adaptations to calorie restriction points to anomalous feedback control of pituitary LH release in PCOS.",
keywords = "Dietary intervention, Feedback regulation, Insulin, Leptin",
author = "{Van Dam}, {Eveline W C M} and Ferdinand Roelfsema and Veldhuis, {Johannes D.} and Helmerhorst, {Frans M.} and Marijke Fr{\"o}lich and {Edo Meinders}, A. and Krans, {H. Michiel J} and Hanno Pijl",
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Van Dam, EWCM, Roelfsema, F, Veldhuis, JD, Helmerhorst, FM, Frölich, M, Edo Meinders, A, Krans, HMJ & Pijl, H 2002, 'Increase in daily LH secretion in response to short-term calorie restriction in obese women with PCOS' American Journal of Physiology - Endocrinology and Metabolism, vol. 282, no. 4 45-4.

Increase in daily LH secretion in response to short-term calorie restriction in obese women with PCOS. / Van Dam, Eveline W C M; Roelfsema, Ferdinand; Veldhuis, Johannes D.; Helmerhorst, Frans M.; Frölich, Marijke; Edo Meinders, A.; Krans, H. Michiel J; Pijl, Hanno.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 282, No. 4 45-4, 29.06.2002.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Increase in daily LH secretion in response to short-term calorie restriction in obese women with PCOS

AU - Van Dam, Eveline W C M

AU - Roelfsema, Ferdinand

AU - Veldhuis, Johannes D.

AU - Helmerhorst, Frans M.

AU - Frölich, Marijke

AU - Edo Meinders, A.

AU - Krans, H. Michiel J

AU - Pijl, Hanno

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N2 - We hypothesized that short-term calorie restriction would blunt luteinizing hormone (LH) hypersecretion in obese women with polycystic ovary syndrome (PCOS) and thereby ameliorate the anovulatory endocrine milieu. To test this hypothesis, 15 obese patients with PCOS and nine age- and body mass index-matched healthy women underwent 24-h blood sampling to quantitate plasma LH, leptin, and insulin levels. PCOS subjects were prescribed a very low caloric liquid diet (4.2 MJ/day) for 7 days and were then resampled. Basal and pulsatile LH secretion was threefold higher in PCOS subjects, but plasma insulin and leptin levels were not different in the calorie-replete state. Contrary to expectation, calorie restriction enhanced basal and pulsatile LH secretion even further. As expected, plasma glucose, insulin, and leptin concentrations decreased by 18, 75, and 50%, respectively. Serum total testosterone concentration fell by 23%, whereas serum estrone, estradiol, sex hormone-binding globulin (SHBG), and androstenedione concentrations remained unchanged. Enhanced LH secretion in the presence of normal metabolic and hormonal adaptations to calorie restriction points to anomalous feedback control of pituitary LH release in PCOS.

AB - We hypothesized that short-term calorie restriction would blunt luteinizing hormone (LH) hypersecretion in obese women with polycystic ovary syndrome (PCOS) and thereby ameliorate the anovulatory endocrine milieu. To test this hypothesis, 15 obese patients with PCOS and nine age- and body mass index-matched healthy women underwent 24-h blood sampling to quantitate plasma LH, leptin, and insulin levels. PCOS subjects were prescribed a very low caloric liquid diet (4.2 MJ/day) for 7 days and were then resampled. Basal and pulsatile LH secretion was threefold higher in PCOS subjects, but plasma insulin and leptin levels were not different in the calorie-replete state. Contrary to expectation, calorie restriction enhanced basal and pulsatile LH secretion even further. As expected, plasma glucose, insulin, and leptin concentrations decreased by 18, 75, and 50%, respectively. Serum total testosterone concentration fell by 23%, whereas serum estrone, estradiol, sex hormone-binding globulin (SHBG), and androstenedione concentrations remained unchanged. Enhanced LH secretion in the presence of normal metabolic and hormonal adaptations to calorie restriction points to anomalous feedback control of pituitary LH release in PCOS.

KW - Dietary intervention

KW - Feedback regulation

KW - Insulin

KW - Leptin

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JO - American Journal of Physiology - Endocrinology and Metabolism

JF - American Journal of Physiology - Endocrinology and Metabolism

SN - 0193-1849

IS - 4 45-4

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