Increased cardiovascular disease risk in women with a history of recurrent miscarriage

Marise M. Wagner, Mary M. Beshay, Sophie Rooijakkers, Wietske Hermes, J. Wouter Jukema, Saskia le Cessie, Christianne J.  M. de Groot, Bart E.  P.  B. Ballieux, Jan M.  M. van Lith, Kitty W.  M. Bloemenkamp

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Introduction: Cardiovascular disease is the leading cause of death in women. Observational studies suggest that women with a history of recurrent miscarriage have an increased risk of cardiovascular disease. Material and methods: Women who visited the recurrent miscarriage clinic at Leiden University Medical Center between 2000 and 2010 and who had their third consecutive miscarriage before the age of 31 years, were invited to participate in this follow-up study (between 2012 and 2014). The reference group consisted of women with at least one uncomplicated pregnancy and no miscarriage, matched by zip code, age, and date of pregnancy. All women were invited for risk factor screening, including physical examination and blood collection. Main outcome measures were the (extrapolated) 10- and 30-year cardiovascular risk scores using the Framingham risk score. A subanalysis was performed for women with idiopathic recurrent miscarriage. Results: Thirty-six women were included in both groups. Mean follow up was 7.5 years. Women with recurrent miscarriage had a significantly higher extrapolated 10-year cardiovascular risk score (mean 6.24%, SD 5.44) compared with women with no miscarriage (mean 3.56%, SD 1.82, P =.007) and a significantly higher 30-year cardiovascular risk score (mean 9.86%, SD 9.10) compared with women with no miscarriage (mean 6.39%, SD 4.20, P =.04). Similar results were found in women with idiopathic recurrent miscarriage (n = 28). Conclusions: Women with a history of recurrent miscarriage differ in cardiovascular risk profile at a young age compared with women with no miscarriage. The findings support an opportunity to identify women at risk of cardiovascular disease later in life and a possible moment for intervention.
Original languageEnglish
Pages (from-to)1192-1199
JournalActa Obstetricia et Gynecologica Scandinavica
Volume97
Issue number10
DOIs
Publication statusPublished - 2018

Cite this

Wagner, M. M., Beshay, M. M., Rooijakkers, S., Hermes, W., Jukema, J. W., le Cessie, S., ... Bloemenkamp, K. W. M. (2018). Increased cardiovascular disease risk in women with a history of recurrent miscarriage. Acta Obstetricia et Gynecologica Scandinavica, 97(10), 1192-1199. https://doi.org/10.1111/aogs.13392
Wagner, Marise M. ; Beshay, Mary M. ; Rooijakkers, Sophie ; Hermes, Wietske ; Jukema, J. Wouter ; le Cessie, Saskia ; de Groot, Christianne J.  M. ; Ballieux, Bart E.  P.  B. ; van Lith, Jan M.  M. ; Bloemenkamp, Kitty W.  M. / Increased cardiovascular disease risk in women with a history of recurrent miscarriage. In: Acta Obstetricia et Gynecologica Scandinavica. 2018 ; Vol. 97, No. 10. pp. 1192-1199.
@article{c25185b47f0d4b479f4a898752ede18c,
title = "Increased cardiovascular disease risk in women with a history of recurrent miscarriage",
abstract = "Introduction: Cardiovascular disease is the leading cause of death in women. Observational studies suggest that women with a history of recurrent miscarriage have an increased risk of cardiovascular disease. Material and methods: Women who visited the recurrent miscarriage clinic at Leiden University Medical Center between 2000 and 2010 and who had their third consecutive miscarriage before the age of 31 years, were invited to participate in this follow-up study (between 2012 and 2014). The reference group consisted of women with at least one uncomplicated pregnancy and no miscarriage, matched by zip code, age, and date of pregnancy. All women were invited for risk factor screening, including physical examination and blood collection. Main outcome measures were the (extrapolated) 10- and 30-year cardiovascular risk scores using the Framingham risk score. A subanalysis was performed for women with idiopathic recurrent miscarriage. Results: Thirty-six women were included in both groups. Mean follow up was 7.5 years. Women with recurrent miscarriage had a significantly higher extrapolated 10-year cardiovascular risk score (mean 6.24{\%}, SD 5.44) compared with women with no miscarriage (mean 3.56{\%}, SD 1.82, P =.007) and a significantly higher 30-year cardiovascular risk score (mean 9.86{\%}, SD 9.10) compared with women with no miscarriage (mean 6.39{\%}, SD 4.20, P =.04). Similar results were found in women with idiopathic recurrent miscarriage (n = 28). Conclusions: Women with a history of recurrent miscarriage differ in cardiovascular risk profile at a young age compared with women with no miscarriage. The findings support an opportunity to identify women at risk of cardiovascular disease later in life and a possible moment for intervention.",
author = "Wagner, {Marise M.} and Beshay, {Mary M.} and Sophie Rooijakkers and Wietske Hermes and Jukema, {J. Wouter} and {le Cessie}, Saskia and {de Groot}, {Christianne J.  M.} and Ballieux, {Bart E.  P.  B.} and {van Lith}, {Jan M.  M.} and Bloemenkamp, {Kitty W.  M.}",
year = "2018",
doi = "10.1111/aogs.13392",
language = "English",
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Wagner, MM, Beshay, MM, Rooijakkers, S, Hermes, W, Jukema, JW, le Cessie, S, de Groot, CJM, Ballieux, BEPB, van Lith, JMM & Bloemenkamp, KWM 2018, 'Increased cardiovascular disease risk in women with a history of recurrent miscarriage' Acta Obstetricia et Gynecologica Scandinavica, vol. 97, no. 10, pp. 1192-1199. https://doi.org/10.1111/aogs.13392

Increased cardiovascular disease risk in women with a history of recurrent miscarriage. / Wagner, Marise M.; Beshay, Mary M.; Rooijakkers, Sophie; Hermes, Wietske; Jukema, J. Wouter; le Cessie, Saskia; de Groot, Christianne J.  M.; Ballieux, Bart E.  P.  B.; van Lith, Jan M.  M.; Bloemenkamp, Kitty W.  M.

In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 97, No. 10, 2018, p. 1192-1199.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Increased cardiovascular disease risk in women with a history of recurrent miscarriage

AU - Wagner, Marise M.

AU - Beshay, Mary M.

AU - Rooijakkers, Sophie

AU - Hermes, Wietske

AU - Jukema, J. Wouter

AU - le Cessie, Saskia

AU - de Groot, Christianne J.  M.

AU - Ballieux, Bart E.  P.  B.

AU - van Lith, Jan M.  M.

AU - Bloemenkamp, Kitty W.  M.

PY - 2018

Y1 - 2018

N2 - Introduction: Cardiovascular disease is the leading cause of death in women. Observational studies suggest that women with a history of recurrent miscarriage have an increased risk of cardiovascular disease. Material and methods: Women who visited the recurrent miscarriage clinic at Leiden University Medical Center between 2000 and 2010 and who had their third consecutive miscarriage before the age of 31 years, were invited to participate in this follow-up study (between 2012 and 2014). The reference group consisted of women with at least one uncomplicated pregnancy and no miscarriage, matched by zip code, age, and date of pregnancy. All women were invited for risk factor screening, including physical examination and blood collection. Main outcome measures were the (extrapolated) 10- and 30-year cardiovascular risk scores using the Framingham risk score. A subanalysis was performed for women with idiopathic recurrent miscarriage. Results: Thirty-six women were included in both groups. Mean follow up was 7.5 years. Women with recurrent miscarriage had a significantly higher extrapolated 10-year cardiovascular risk score (mean 6.24%, SD 5.44) compared with women with no miscarriage (mean 3.56%, SD 1.82, P =.007) and a significantly higher 30-year cardiovascular risk score (mean 9.86%, SD 9.10) compared with women with no miscarriage (mean 6.39%, SD 4.20, P =.04). Similar results were found in women with idiopathic recurrent miscarriage (n = 28). Conclusions: Women with a history of recurrent miscarriage differ in cardiovascular risk profile at a young age compared with women with no miscarriage. The findings support an opportunity to identify women at risk of cardiovascular disease later in life and a possible moment for intervention.

AB - Introduction: Cardiovascular disease is the leading cause of death in women. Observational studies suggest that women with a history of recurrent miscarriage have an increased risk of cardiovascular disease. Material and methods: Women who visited the recurrent miscarriage clinic at Leiden University Medical Center between 2000 and 2010 and who had their third consecutive miscarriage before the age of 31 years, were invited to participate in this follow-up study (between 2012 and 2014). The reference group consisted of women with at least one uncomplicated pregnancy and no miscarriage, matched by zip code, age, and date of pregnancy. All women were invited for risk factor screening, including physical examination and blood collection. Main outcome measures were the (extrapolated) 10- and 30-year cardiovascular risk scores using the Framingham risk score. A subanalysis was performed for women with idiopathic recurrent miscarriage. Results: Thirty-six women were included in both groups. Mean follow up was 7.5 years. Women with recurrent miscarriage had a significantly higher extrapolated 10-year cardiovascular risk score (mean 6.24%, SD 5.44) compared with women with no miscarriage (mean 3.56%, SD 1.82, P =.007) and a significantly higher 30-year cardiovascular risk score (mean 9.86%, SD 9.10) compared with women with no miscarriage (mean 6.39%, SD 4.20, P =.04). Similar results were found in women with idiopathic recurrent miscarriage (n = 28). Conclusions: Women with a history of recurrent miscarriage differ in cardiovascular risk profile at a young age compared with women with no miscarriage. The findings support an opportunity to identify women at risk of cardiovascular disease later in life and a possible moment for intervention.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85052984178&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/29806956

U2 - 10.1111/aogs.13392

DO - 10.1111/aogs.13392

M3 - Article

VL - 97

SP - 1192

EP - 1199

JO - Acta Obstetricia et Gynecologica Scandinavica

JF - Acta Obstetricia et Gynecologica Scandinavica

SN - 0001-6349

IS - 10

ER -